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Item Metadata only Comparison of estradiol hemihydrate 10 µg vaginal tablets versus estradiol hemihydrate 10 µg vaginal gel in postmenopausal women with vaginal atrophy: a randomized crossover study(2025-01-01) Taemamu K.; Tanmahasamut P.; Rattanachaiyanont M.; Wongwananuruk T.; Chantrapanichkul P.; Areeswate C.; Taemamu K.; Mahidol UniversityAim: This randomized crossover study evaluated the 12 week efficacy of a 10 µg estradiol hemihydrate vaginal tablet versus a vaginal gel (available at Siriraj Hospital, Thailand) in postmenopausal women with vaginal atrophy. Secondary endpoints... a preference for continued gel use. Conclusions: Noninferiority of the 10 µg estradiol hemihydrate tablet relative to the gel could not be established. However, both treatments exhibited clinical benefits and high patient satisfaction, providingPublication Metadata only An orthorhombic polymorph of melaminium chloride hemihydrate(2007-12-01) Umporn Athikomrattanakul; Chamras Promptmas; Martin Katterle; Uwe Schilde; Mahidol University; Universitat PotsdamCrystals of an ortho-rhom-bic polymorph of 2,4,6-triamino-1,3,5-triazin-1- ium chloride hemihydrate, C3H7N6+·Cl-·0. 5H2O, were obtained by cocrystallization experiments under aqueous acidic conditions (HCl, pH = 2). In the crystal structurePublication Metadata only N-Acetyl-3,5-dibromo-L-tyrosine hemihydrate(2012-09-01) Pakorn Bovonsombat; John Snyder; Francesco Caruso; Miriam Rossi; Mahidol University; Vassar College; Consiglio Nazionale delle RicercheThe title compound, C 11 H 11 Br 2 NO 4 ·0.5H 2 O, was prepared by an electrophilic bromination of N-acetyl-l-tyrosine in acetonitrile at room temperature. The two independent molecules do not differ substanti-ally and a molecule of water completes the asymmetric unit. The synthesis of the title compound does not modify the stereochemical center, as shown by the absolute configuration found in this crystal structure. Comparison with the non-bromo starting material differs mainly by rotation features. For instance the H(methine) - C(chiral center) - C(methyl-ene) - C(ipso) is 173.0 (2)° torsion angle in one molecule and 177.3 (2)° in the other, indicating a trans arrangement. This is in contrast with approximately 50° in the starting material. A short Intermolecular Br⋯Br separation is observed [3.2938 (3) Å]. The molecules in the crystal are connected via a network of hydrogen bonds through an N - H⋯O hydrogen bond between the hydroxy group of the phenol of the tyrosine and the N - H of the amide of the other molecule and an O - H⋯O hydrogen bond between the hydroxy group of the carboxylic acid and the oxygen of the carbonyl of the amide.Publication Metadata only Preparation of dry reconstituted liposomal powder by freeze-drying at room temperature(2011-03-01) Ruthairat Benjakul; Busaba Panyarachun; Narong Sarisuta; Mahidol University; Faculty of Medicine, Thammasat Universitywas based on utilizing sublimation of a volatile solid inert carrier, that is, chlorobutanol hemihydrate (CBN), instead of ice, which was less sophisticated and simpler than the conventional freeze-drying process. The optimum conditions usedPublication Metadata only Novel freeze-drying method for preparation of α-mangostin dry reconstitute liposomal powder(2012-05-01) Ruthairat Benjakul; Primchanien Moongkarndi; Busaba Panyarachun; Narong Sarisuta; Mahidol University; Faculty of Medicine, Thammasat Universityat room temperature with various molar ratios of phosphatidylcholine to cholesterol. The method was based on utilizing sublimation of volatile solid inert carrier, chlorobutanol hemihydrate, instead of ice in conventional freeze-drying process. The optimum