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Item Open Access Effectiveness and risk-benefit analysis of urate lowering therapy in asymptomatic hyperuricemia : a real-world study(Mahidol University. Mahidol University Library and Knowledge Center, 2021) Tunlanut Sapankaew; Atiporn Ingsathit; Kunlawat Thadanipon; Ammarin ThakkinstianHyperuricemia was associated with a higher risk of multiple chronic diseases. Several studies were conducted on urate-lowering therapy agents (ULT) in asymptomatic hyperuricemia, whereas few studies focused on clinical outcomes of cardiovascular... hyperuricemia, who were free of major adverse cardiovascular event (MACE), i.e., acute myocardial infarction, cerebrovascular accident, and cardiovascular death, and renal replacement therapy (RRT) at inception and prescribed with or without any ULTItem Open Access Deep learning based technique for classification of abdominal aortic aneurysm (AAA) in ct-scan images(Mahidol University, 2023) Miao, Zhiqi, 1998-; Worapan Kusakunniran; Thanongchai Siriapisith; Pairash SaiviroonpornAbdominal aortic aneurysm (AAA) is known as an extremely dangerous cardiovascular disease for the elderly, with a high probability of death within an exceedingly short period of time. Therefore, the goal of our proposed method is to create a model... of patients by reducing the probability of compulsory use of CTA with health-harmful contrast agents for the precise diagnosis. Implication of the thesis: (i) The precise and quick determination of the AAA with the heatmap as a reference of our work would saveItem Open Access คู่มือยา 1(2522) นงลักษณ์ เพียรอุสาหะ; ปรานี ภิญโญวัฒยากร; สมพงษ์ กิตติพงษ์หรรษา; หนู สมจรรยากุล; อุดม สุขพิพัฒน์; ธิดา นิงสานนท์; มหาวิทยาลัยมหิดล. คณะเภสัชศาสตร์Item Open Access Clinical effectiveness and cost-utility analysis of phosphate binders for treating hyperphosphatemia in end-stage renal disease patients : a multicenter real-world study(Mahidol University, 2022) Kamolpat Chaiyakittisopon; Ammarin Thakkinstian; Atiporn IngsathitUncontrolled hyperphosphatemia in end-stage renal disease (ESRD) patients increases the risk of cardiovascular disease (CVD), bone disorders, and mortality. Phosphate binders (PBs) are recommended as a treatment option. Calcium-based PBs (CBPBs) hadPublication Open Access The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease.(2013-07) Kikuchi, Kiyoshi; Salunya Tancharoen; ศรัณยา ตันเจริญ; Takeshige, Nobuyuki; Yoshitomi, Munetake; Morioka, Motohiro; Murai, Yoshinaka; Tanaka, Eiichiro; Mahidol University. Faculty of Dentistry. Department of Pharmacology, such as cardiovascular diseases and stroke. Therefore, free radicals may be targets for therapeutic intervention in these diseases. Edaravone shows protective effects on ischemic insults and inflammation in the heart, vessel, and brain in experimental studies. As well... as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic, and anti-cytokine effects in cardiovascular diseases and stroke. Edaravone has preventive effects on myocardial injury following ischemia and reperfusion in patients with acute myocardialPublication Open Access Validity and reliability of the ankle-brachial index by oscillometric blood pressure and automated ankle-brachial index(2017) Sukanya Chongthawonsatid; Somchai Dutsadeevettakul; Mahidol University. Faculty of Social Sciences and Humanities. Department of Social Sciences; Mahidol University. Golden Jubilee Medical Center. Department of MedicineBackground: This study was conducted to assess the validity and reliability of ankle‑brachial index (ABI) by oscillometric blood pressure (BP) measurement as compared with an automated ABI as a gold standard. Materials and Methods: This study was conducted at Golden Jubilee Medical Center, Thailand. All the data were collected from 303 patients at risk of peripheral arterial disease (PAD) who were 45 years of age or above and who underwent treatment at the outpatient medical clinic between June and December 2015. Patients who were followed up at the medical clinic had both oscillometric BP measurement (Terumo, ES‑P600) and an automated ABI (oscillometric method) at the same time. Sensitivity, specificity, positive predictive value, and negative predictive value of the oscillometric BP measurements to predict an abnormal ABI (<0.90) were determined using the automated ABI as the gold standard. Results: ABI values were similar between the two methods. The oscillometric BP method for determining an ABI (cutoff point <0.90) on the right side had a sensitivity of 88.89%, specificity of 99.32%, an accuracy of 99.01%, a positive predictive value of 80%, and a negative predictive value of 99.32% whereas ABI on the left side had a sensitivity of 69.23%, a specificity of 99.66%, an accuracy of 98.35%, a positive predictive value of 90%, and a negative predictive value of 98.63%. Reliability of the oscillometric BP method by Kappa statistics was 0.84 on the right side and 0.77 on the left side (P = 0.000). Conclusion: The oscillometric BP method is a reliable and useful alternative to conventional automated ABI determination in patients with no severe arterial occlusion for estimation of the prevalence and screening of PAD in primary health‑care settings.Publication Open Access Effect of high concentration lidocaine for mandibular teeth anesthesia: Review literature.(2015-01-27) Sirichai Kiattavorncharoen; ศิริชัย เกียรติถาวรเจริญ; Chavengkiat Saengsirinavin; เชวงเกียรติ แสงศิรินาวิน; Natthamet Wongsirichat; ณัฐเมศร์ วงศ์สิริฉัตร; Ping, Bushara; Im, Puthavy; Durward, Cullum; Natthamet Wongsirichat; ณัฐเมศร์ วงศ์สิริฉัตร; Mahidol University. Faculty of Dentistry. Department of Oral and Maxillofacial SurgeryInferior alveolar nerve block (IANB) is the most regularly used technique to anesthetize the mandibular teeth. Many authors have reported IAN block does not always result in completely success of pulpal anesthesia for the duration of the operation. The failure rates of pulpal anesthesia were reported from 10% to 39%. Many researches were manipulated several of ways to enhance the efficacy of local anesthetic use in dentistry. Many articles prove that high pH of local anesthetic enhances ionization property and provides sufficiency onset of local anesthetic. Furthermore, increasing concentration of lidocaine results in superior success rate compare to 2% lidocaine. To make a clear impression in effect of high concentration of lidocaine in mandibular anesthesia the further investigation should be encouraged. This review is to conclude ideas of related papers which studied in effect of increase concentration of lidocaine local anesthetic with vasoconstrictor in intraoral anesthesia.Publication Open Access Phenotypic alterations in human saphenous vein culture induced by tumor necrosis factor-alpha and lipoproteins: a preliminary development of an initial atherosclerotic plaque model(2013) Kriengchai Prasongsukarn; Urai Chaisri; Peenutchanee Chartburus; Kamolwan Wetchabut; Surachet Benjathummarak; Vasant Khachansaksumet; Yaowapa Maneerat; Mahidol University. Faculty of Tropical Medicine. Department of Tropical PathologyBackground: Atherosclerosis is a chronic progressive inflammatory disease of blood vessels particularly the arteries. The development of atherosclerotic plaques or atherogenesis is a complex process that is influenced by cardiovascular risk...g/ml for 14 days. The phenotypic changes of the organ cultures characteristic of initial atherosclerotic plaques were evaluated. The effect of anti-atherogenic agent, 17-β estradiol (E2), was also determined. Results: Histologic, histomorphometricPublication Open Access Chaotropic effect in reversed-phase HPLC: A review(2010) C.M. Phechkrajang; Chutima (Matayatsuk)Phechkrajang; ชุติมา(มัธยัสถ์สุข)เพ็ชรกระจ่าง; Mahidol University. Faculty of Pharmacy. Department of Pharmaceutical ChemistrySome inorganic anions such as BF4-, CF3COO-, ClO4-, and H2PO4-, can affect the solubility of proteins and amino acids. Their effects were observed since 1888 by Fran Hofmeister. During the past decade, these ions have been used increasingly in reversed-phase high-performance liquid chromatography (HPLC), because of their abilities to improve the retention of basic substances in their protonated forms without changing a new column or mobile phase pH. Moreover, addition of these ions in mobile phase can improve theoretical plate number and tailing factor as well.Publication Open Access Epidemiology of bacteremia caused by uncommon non-fermentative gram-negative bacteria(2013) Pinyo Rattanaumpawan; Prapassorn Ussavasodhi; Pattarachai Kiratisin; Nalinee Aswapokee; Mahidol University. Faculty of Medicine Siriraj Hospital. Division of Infectious Diseases and Tropical MedicineBackground: Prevalence of bacteremia caused by non-fermentative gram-negative bacteria (NFGNB) has been increasing over the past decade. Although many studies have already investigated epidemiology of NFGNB bacteremia, most focused only on common NFGNB including Pseudomonas aeruginosa (PA) and Acinetobacter baumannii (AB). Knowledge of uncommon NFGNB bacteremia is very limited. Our study aimed to investigate epidemiology and identify factors associated with uncommon NFGNB bacteremia. Methods: This observational study was conducted at a university hospital in Thailand during July 1, 2007-Dec 31, 2008. All patients who had at least one blood culture positive for NFGNB and met the criteria for systemic inflammatory response syndrome within 24 hours before/after obtaining the blood culture were enrolled. The NFGNB isolates that could not be satisfactorily identified by the standard biochemical assays were further characterized by molecular sequencing methods. To identify factors associated with uncommon NFGNB bacteremia, characteristics of patients in the uncommon NFGNB group were subsequently compared to patients in the common NFGNB group (AB and PA bacteremia). Results: Our study detected 223 clinical isolates of NFGNB in 221 unique patients. The major causative pathogens were AB (32.7%), followed by PA (27.8%), Stenotrophomonas maltophilia (5.4%), Acinetobacter lwoffii (4.9%) and Burkholderia pseudomallei (2.7%). Infection-related mortality was 63.0% in the AB group, 40.3% in the PA group and 17.4% in the uncommon NFGNB group. Factors associated with uncommon NFGNB bacteremia (OR [95% CI]; p-value) were male sex (0.28 [0.14-0.53]; p < 0.001), hospital-acquired infection (0.23 [0.11-0.51]; p < 0.001), recent aminoglycosides exposure 0.23 [0.06-0.8]; p = 0.01), primary bacteremia (6.43 [2.89-14.2]; p < 0.001]), catheter related infection (4.48 [1.54-13.06]; p < 0.001) and recent vancomycin exposure (3.88 [1.35-11.1]; p = 0.02). Conclusions: Our distribution of causative pathogens was slightly different from other studies. The common NFGNB group had a remarkably higher ID-mortality than the uncommon NFGNB group. Knowledge of factors associated with uncommon NFGNB bacteremia would help physicians to distinguish between low vs. high risk patients.