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Publication Open Access Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006.(2010-03) Fried, Jessica R.; Gibbons, Robert V.; Siripen Kalayanarooj; Thomas, Stephen J.; Anon Srikiatkhachorn,; Yoon, In-Kyu; Jarman, Richard G.; Green, Sharone; Rothman, Alan L.; Cummings, Derek A. T.; Fried, Jessica R.; Mahidol University. Faculty of Tropical Medicine. Mahidol Oxford Tropical Medicine Research Unit (MORU).Background It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand. Methodology.../Principal Findings Prospective studies were conducted from 1994 to 2006. Univariate and multivariate logistic and multinomial logistic regressions were used to determine if dengue hemorrhagic fever (DHF) and signs of severe clinical disease (pleural effusionPublication Open Access Genetic modifiers of Hb E/β0 thalassemia identified by a two-stage genome-wide association study(2010) Richard Sherva; Orapan Sripichai; Kenneth Abel; Qianli Ma; Johanna Whitacre; Vach Angkachatchai; Wattanan Makarasara; Pranee Winichagoon; Saovaros Svasti; Suthat Fucharoen; Andreas Braun; Lindsay A Farrer; Mahidol University. Institute of Molecular Biosciences. Thalassemi a Research Center; Mahidol University. Faculty of Science. Department of BiochemistryBackground Patients with Hb E/β0 thalassemia display remarkable variability in disease severity. To identify genetic modifiers influencing disease severity, we conducted a two-stage genome scan in groups of 207 mild and 305 severe unrelated... associated with disease severity (P < 0.05) after Bonferroni adjustment for multiple testing. Forty-one SNPs in a large LD block within the β-globin gene cluster had major alleles associated with severe disease. The most significant was bthal_bg200 (oddsPublication Open Access Clinical severity of β-thalassaemia/Hb E disease is associated with differential activities of the calpain-calpastatin proteolytic system(2012-05) Suriyan Sukati; Saovaros Svasti; Stifanese, Roberto; Averna, Monica; Nantika Panutdaporn; Tipparat Penglong; Melloni, Edon; Suthat Fucharoen; Katzenmeier, Gerd; Mahidol University. Institute of Molecular Biosciences; Mahidol University. Faculty of Science. Department of Biochemistryto the activity of calpain protease. The aim of this study was to correlate the activity of calpain and its inhibitor, calpastatin, with different degrees of disease severity in β-thalassaemia. CD34+ cells were enriched from peripheral blood of healthy individuals... (control group) and patients with mild and severe clinical presentations of β0-thalassaemia/Hb E disease. By ex vivo cultivation promoting erythroid cell differentiation for 7 days, proerythroblasts, were employed for the functional characterizationPublication Open Access ปัจจัยที่มีอิทธิพลต่อการทำหน้าที่ทางเพศของผู้ป่วยชายที่มีภาวะหัวใจขาดเลือดเฉียบพลันภายหลังการขยายหลอดเลือดหัวใจ(2566) เตือนใจ โพธิ์ประดับ; จงจิต เสน่หา; ศรินรัตน์ ศรีประสงค์; ธรรมรัฐ ฉันทแดนสุวรรณ; Tueanchai Popradab; Chongjit Saneha; Sarinrut Sriprasong; Thamarath ChantadansuwanPurpose: The research aimed to study the influence of disease severity, fear of movement, sexual knowledge and patient healthcare provider communication on sexual function of the male patients with acute coronary syndrome post percutaneous coronary... and illness data including disease severity, fear of movement, sexual knowledge, patient healthcare provider communication, and sexual function. Data were analyzed using descriptive statistics and multiple regression analysis. Main findings: The resultsPublication Open Access Identification of clinical factors associated with severe dengue among Thai adults: a prospective study(2015) Vipa Thanachartwet; Nittha Oer-areemitr; Supat Chamnanchanunt; Duangjai Sahassananda; Akanitt Jittmittraphap; Plengsakoon Suwannakudt; Varunee Desakorn; Anan Wattanathum; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical MedicineBackground: Dengue is the most common mosquito-borne viral disease in humans. Recently, there has been an epidemic shift of dengue from mainly affecting children to affecting more adults with increased severity. However, clinical factors... associated with severe dengue in adults have varied widely between studies. We aimed to identify the clinical factors associated with the development of severe dengue according to the World Health Organization (WHO)’s 2009 definition. Methods: We conductedItem Open Access The development of multiplex one-step real-time rt-pcr for simultaneous detection variants of severe acute respiratory syndrome-coronavirus-2(Mahidol University. Mahidol University Library and Knowledge Center, 2022) Natsada Saengdao; Kamol Suwannakarn; Chutikarn Chaimayo; Navin Horthongkhamgenerates several novel varieties due to its high rate of mutation. Therefore, to find the new variations and use as a screening method for SARS-CoV-2, a one-step real-time RT-PCR with specific primers and probes could be developed.Item Open Access สารารมณ์ 1 หลายเรื่อง หลากรส รวยอารมณ์ กับหมอประเสริฐ-2549(2549) ประเสริฐ ทองเจริญ; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์ศิริราชพยาบาลPublication Open Access Identification and key management of non-transfusion-dependent thalassaemia patients: not a rare but potentially under-recognised condition(2014) Vip Viprakasit; Tyan, Paul; Sarayuth Rodmai; Taher, Ali T.; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pediatrics and Thalassemia CenterPatients with non-transfusion-dependent thalassaemia (NTDT) have a genetic defect or combination of defects that affect haemoglobin synthesis, but which is not severe enough to require regular blood transfusions. The carrier frequency of NTDT... is high (up to 80% in some parts of the world) but the prevalence of symptomatic patients varies with geography and is estimated to be from 1 in 100,000 to 1 in 100. NTDT has a variable presentation that may include mild to severe anaemia, enlargedPublication Open Access Diagnostic accuracy of peripheral venous lactate and the 2009 WHO warning signs for identifying severe dengue in Thai adults: a prospective observational study(2016) Vipa Thanachartwet; Anan Wattanathum; Oer-areemitr, Nittha; Akanitt Jittmittraphap; Duangjai Sahassananda; Chalida Monpassorn; Manoon Surabotsophon; Varunee Desakorn; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical MedicineBackground: Dengue is the most common mosquito-borne viral disease in humans. However, the sensitivities of warning signs (WSs) for identifying severe dengue in adults are low, and the utility of lactate levels for identifying severe dengue... in adults has not been verified. Therefore, we aimed to evaluate the diagnostic accuracy of using peripheral venous lactate levels (PVL), as well as WSs established by the World Health Organization, for identifying severe dengue. Methods: We prospectivelyPublication Open Access A cost-utility and budget impact analysis of allogeneic hematopoietic stem cell transplantation for severse thalasssemic patients in Thailand(2010-07-16) Pattara Leelahavarong; Usa Chaikledkaew; Suradej Hongeng; Vijj Kasemsup; Lubell, Yoel; Yot Teerawattananon; พัทธรา ลีฬหวรงค์; อุษา ฉายเกล็ดแก้ว; สุรเดช หงส์อิง; วิชช์ เกษมทรัพย์; ยศ ตีระวัฒนานนท์; Usa Chaikledkaew; Pattara Leelasavarong; Mahidol University. Faculty of Pharmacy. Department of Pharmacyadditional THB per year. Conclusions: At a societal willingness to pay of 100,000 THB per QALY gained, related HSCT was likely to be a cost-effective and affordable treatment for young children with severe thalassemia in Thailand