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Publication Metadata only HLA-Associated immune pressure on gag protein in CRF01_AE-Infected individuals and its association with plasma viral load(2010-08-11) Goragoch Gesprasert; Nuanjun Wichukchinda; Masahiko Mori; Teiichiro Shiino; Wattana Auwanit; Busarawan Sriwanthana; Panita Pathipvanich; Pathom Sawanpanyalert; Toshiyuki Miura; Prasert Auewarakul; Arunee Thitithanyanont; Koya Ariyoshi; Mahidol University; Thailand Ministry of Public Health; Nagasaki University; National Institute of Infectious Diseases; Lampang Hospital; Institute of Medical Science The University of Tokyoof the amino acid variations associated with the host HLA type and their clinical relevance for the Asian population. Here, we identified HLA-associated polymorphisms in the HIV-1 CRF01_AE Gag protein in infected married couples, and examined the consequences... and directly sequenced. We identified 56 associations between amino acid variations in Gag and HLA alleles. Of those amino acid variations, 35 (62.5%) were located within or adjacent to regions reported to be HIV-specific CTL epitopes restricted by the relevantPublication Metadata only Common TLR1 genetic variation is not associated with death from melioidosis, a common cause of sepsis in rural Thailand(2014-01-02) Narisara Chantratita; Sarunporn Tandhavanant; Nicolle D. Myers; Wirongrong Chierakul; Vanaporn Wuthiekanun; Weera Mahavanakul; Direk Limmathurotsakul; Sharon J. Peacock; T. Eoin West; Mahidol University; University of Washington, Seattle; Sappasitthiprasong Hospital; University of CambridgeMelioidosis, infection caused by the Gram-negative bacterium Burkholderia pseudomallei, is a common cause of sepsis in northeast Thailand. In white North Americans, common functional genetic variation in TLR1 is associated with organ failure... and death from sepsis. We hypothesized that TLR1 variants would be associated with outcomes in Thais with melioidosis. We collated the global frequencies of three TLR1 variants that are common in white North American populations: rs5743551 (-7202A/G), rsItem Metadata only Shortening Leukocyte Telomere Length Associated With Elevated Blood Diabetes–Related Cardiovascular Risk Factor in Thai Adolescents(2025-08-01) Luealai P.; Pongcharoen T.; On-Nom N.; Suttisansanee U.; Temviriyanukul P.; Kriengsinyos W.; Khemthong C.; Chupeerach C.; Luealai P.; Mahidol UniversityLeukocyte telomere length (LTL) is considered a reliable biological indicator of aging. LTL shortening has been associated with an increased risk of cardiometabolic markers among adults. However, evidence for an association in adolescents is limited.... This cross-sectional study examined the association between blood biomarkers of cardiovascular diseases and leukocyte telomere length in 59 Thai adolescents with mean age 15 years. Blood samples and anthropometric, clinical, and biochemical data werePublication Metadata only Case-control approach to identify Plasmodium falciparum polymorphisms associated with severe malaria(2009-05-06) Watcharee Chokejindachai; David J. Conway; London School of Hygiene & Tropical Medicine; Mahidol University; Medical Research Council Laboratories GambiaBackground: Studies to identify phenotypically-associated polymorphisms in the Plasmodium falciparum 23 Mb genome will require a dense array of marker loci. It was considered promising to undertake initial allelic association studies to prospect... (Index of Association, ISA= 0.013, P = 0.10), while those on chromosome 2 showed significant LD values mostly between loci <5 kb apart. A disease association study was then performed comparing parasites in 113 severe malaria cases and 245 mild malariaPublication Metadata only Evaluation of distribution and chemical associations between cobalt and manganese in soils by continuous-flow sequential extraction(2005-10-01) N. Tongtavee; J. Shiowatana; R. G. McLaren; J. Buanuam; Mahidol University; Lincoln University, New ZealandIn this study, a strong association between cobalt (Co) and manganese (Mn) in different geochemical soil phases (fractions) was evaluated using a continuous-flow sequential extraction technique employing a modified Tessier extraction scheme... the elements dissolving in the same extraction step are closely associated, or are merely extractable with the same reagent. From the soil samples studied, the coincidence of Co and Mn peaks seems to indicate a close association of these elementsPublication Metadata only Salivary and serum interleukin-17A and interleukin-18 levels in patients with type 2 diabetes mellitus with and without periodontitis(2020-01-01) Suteera Techatanawat; Rudee Surarit; Kongthawat Chairatvit; Weerapan Khovidhunkit; Sittiruk Roytrakul; Supanee Thanakun; Hiroaki Kobayashi; Siribang On Piboonniyom Khovidhunkit; Yuichi Izumi; Chulalongkorn University; Rangsit University; Mahidol University; Thailand National Center for Genetic Engineering and Biotechnology; Tokyo Medical and Dental University; Srinakharinwirot University; Southern Tohoku General Hospital, and 4) was used to classify whether these subjects had periodontitis. Salivary and serum IL-17A and IL-18 levels were measured by enzyme-linked immunosorbent assay. Multiple linear regression analyses were used to evaluate the associations between....031). Salivary IL-17A levels were significantly associated with the PSR index (β = 0.369, p = 0.011). Multiple linear regression analyses revealed the association of salivary IL-18 levels and fasting plasma glucose (β = 0.270, p = 0.022) whereas serum IL-18Publication Metadata only Association of antioxidant status and inflammatory markers with metabolic syndrome in Thais(2019-01-03) Kanjana Suriyaprom; Sarunya Kaewprasert; Pumpath Putpadungwipon; Pisit Namjuntra; Suwit Klongthalay; Rangsit University; Mahidol University© 2019 The Author(s). Background: An oxidant/antioxidant disequilibrium has been suggested as having a role in the pathogenesis of some diseases. Metabolic syndrome (MS) is significantly associated with cardiovascular disease and type 2 diabetes... except the white blood cell (WBC) count which was significantly higher in those with MS. SOD and CAT levels were significantly positively associated with HDL-C levels and negatively associated with components of MS. After adjusting for potentialPublication Metadata only Nuclear targeted Saccharomyces cerevisiae asparagine synthetases associate with the mitotic spindle regardless of their enzymatic activity(2020-12-01) Chalongrat Noree; Naraporn Sirinonthanawech; Mahidol University© 2020 Noree, Sirinonthanawech. Recently, human asparagine synthetase has been found to be associated with the mitotic spindle. However, this event cannot be seen in yeast because yeast takes a different cell division process via closed mitosis... (there is no nuclear envelope breakdown to allow the association between any cytosolic enzyme and mitotic spindle). To find out if yeast asparagine synthetase can also (but hiddenly) have this feature, the coding sequences of green fluorescent protein (GFP) and nuclearPublication Metadata only Fatal, virus-associated peripheral neuropathy and retinopathy in farmed Penaeus monodon in eastern Australia. I. Pathology(2003-02-27) R. B. Callinan; L. Jiang; P. T. Smith; C. Soowannayan; NSW Fisheries; Western Sydney University; Mahidol UniversityLesions are described in farmed Penaeus monodon affected with a previously unreported, fatal disease, 'peripheral neuropathy and retinopathy' (PNR). Outbreaks, associated with minor to heavy mortalities, occurred in 22 of 25 ponds on a farm... appendages. Histologically, there was mild to severe, focal to diffuse degeneration and necrosis of axons and their sheaths, together with associated glial cell apoptosis, in peripheral nerve fibres. Of the 3 appendage types examined systematicallyPublication Metadata only Association between Internet addiction and depression in Thai medical students at Faculty of Medicine, Ramathibodi Hospital(2017-03-01) Thummaporn Boonvisudhi; Sanchai Kuladee; Mahidol Universityand source are credited. Objective: To study the extent of Internet addiction (IA) and its association with depression in Thai medical students. Methods: A cross-sectional study was conducted at Faculty of Medicine, Ramathibodi Hospital. Participants were... Questionnaire (PHQ-9). A total score of five or greater derived from the Thai version of Young Diagnostic Questionnaire for Internet Addiction was classified as "possible IA". Then chi-square test and logistic regression were used to evaluate the associations