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Publication Open Access Severe vivax malaria: a systematic review and meta-analysis of clinical studies since 1900(2014) Rahimi, Bilal Ahmad; Ammarin Thakkinstian; White, Nicholas J; Chukiat Sirivichayakul; Dondorp, Arjen M; Watcharee Chokejindachai; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unitarticles published since 1900. Medline and Scopus databases were searched for original papers on severe vivax malaria, using as inclusion criteria modified 2010 WHO criteria for the diagnosis of severe falciparum malaria. Articles before 1949 were...Background: Malaria caused by Plasmodium vivax was long considered to have a low mortality, but recent reports from some geographical areas suggest that severe and complicated vivax malaria may be more common than previously thought. MethodsPublication Open Access Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study(2012) Rijken, Marcus J; Merel Charlotte de Wit; Mulder, Eduard JH; Suporn Kiricharoen; Noaeni Karunkonkowit; Tamalar Paw; Visser, Gerard HA; McGready, Rose; Nosten, François H; Pistorius, Lourens R; Mahidol University. Faculty of Tropical MedicineBackground: Malaria in pregnancy has a negative impact on foetal growth, but it is not known whether this also affects the foetal nervous system. The aim of this study was to examine the effects of malaria on foetal cortex development by three... grading was possible in 161 out of 223 (72%) serial foetal brain images in pregnant women living in a malaria endemic area. There was no difference between foetal cortical development or brain volumes at any time in pregnancy between womenPublication Open Access Long‑term impact of childhood malaria infection on school performance among school children in a malaria endemic area along the Thai–Myanmar border(2015) Nutchavadee Vorasan; Wirichada Pan‑Ngum; Podjanee Jittamala; Wanchai Maneeboonyang; Prasert Rukmanee; Saranath Lawpoolsri; Mahidol University. Faculty of Tropical Medicine. Department of Tropical HygieneBackground: Children represent a high-risk group for malaria worldwide. Among people in Thailand who have malaria during childhood, some may have multiple malaria attacks during their lifetime. Malaria may affect neurological cognition in children..., resulting in short-term impairment of memory and language functions. However, little is known regarding the long-term effects of malaria infection on cognitive function. This study examines the long-term impact of malaria infection on school performancePublication Open Access The role of previously unmeasured organic acids in the pathogenesis of severe malaria(2015) Herdman, M. Trent; Natthida Sriboonvorakul; Leopold, Stije J.; Sam Douthwaite; Sanjib Mohanty; M. Mahtab Uddin Hassan; Maude, Richard J.; Kingston, Hugh WF; Katherine Plewes; Prakaykaew Charunwatthana; Kamolrat Silamut; Woodrow, Charles J.; Kesinee Chotinavich; Hossain, Md. Amir; Faiz, M. Abul; Saroj Mishra; Natchanun Leepipatpiboon; White, Nicholas J.; Day, Nicholas PJ; Joel Tarning; Dondorp, Arjen M.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research UnitIntroduction: Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria. Methods: In this prospective... study, we characterised organic acids in adults with severe falciparum malaria in India and Bangladesh. Liquid chromatography-mass spectrometry was used to measure organic acids in plasma and urine. Patients were followed until recovery or deathPublication Open Access Performance of C-reactive protein and procalcitonin to distinguish viral from bacterial and malarial causes of fever in Southeast Asia(2015) Yoel Lubell; Blacksell, Stuart D.; Susanna Dunachie; Ampai Tanganuchitcharnchai; Thomas Althaus; Wanitda Watthanaworawit; Paris, Daniel H.; Mayfong Mayxay; Peto, Thomas J.; Dondorp, Arjen M.; White, Nicholas J.; Day, Nicholas P.J.; François Nosten; Newton, Paul N.; Paul Turner; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit (MORU)Background: Poor targeting of antimicrobial drugs contributes to the millions of deaths each year from malaria, pneumonia, and other tropical infectious diseases. While malaria rapid diagnostic tests have improved use of antimalarial drugs... common viral and bacterial infections in malaria endemic settings of Southeast Asia. Methods: Serum procalcitonin and CRP levels were measured in stored serum samples from febrile patients enrolled in three prospective studies conducted in CambodiaPublication Open Access Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria(2012-08-16) Thiranut Ramutton; Hendriksen, Ilse CE; Mwanga-Amumpaire, Juliet; Mtove, George; Olaosebikan, Rasaq; Tshefu, Antoinette K.; Onyamboko, Marie A.; Karema, Corine; Maitland, Kathryn; Gomes, Ermelinda; Gesase, Samwel; Reyburn, Hugh; Kamolrat Silamut; Kesinee Chotivanich; เกศินี โชติวานิช; Kamoltip Promnares; Fanello, Caterina I.; Seidlein, Lorenz von; Day, Nicholas P.J.; White, Nicholas J.; Dondorp, Arjen M.; Mallika Imwong; มัลลิกา อิ่มวงศ์; Woodrow, Charles J.; Woodrow, Charles J.; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.; Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.BACKGROUND: Plasmodium falciparum histidine-rich protein PFHRP2 measurement is used widely for diagnosis, and more recently for severity assessment in falciparum malaria. The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene... countries contributing to the largest hospital-based severe malaria trial (AQUAMAT). The quantitative relationship between sequence polymorphism and PFHRP2 plasma concentration was examined in samples from selected sites in Mozambique and TanzaniaPublication Open Access Acute Renal Failure in Patients with Severe Falciparum Malaria: Using the WHO 2006 and RIFLE Criteria(2013) Vipa Thanachartwet; วิภา ธนาชาติเวทย์; Varunee Desakorn; วารุณี เทศะกรณ์; Duangjai Sahassananda; ดวงใจ สหัสสานนท์; Kyaw Win, Ko Ko Yazar; Thanom Supaporn; Vipa Thanachartwet; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical MedicineThere are limited data on the application of the RIFLE criteria among patients with severe malaria. This retrospective study was conducted by reviewing 257 medical records of adult hospitalized patients with severe falciparum malaria at the Mae... Sot General Hospital, Tak province in the northern part of Thailand. The aims of this study were to determine the incidence of acute renal failure (ARF) in patients with severe falciparum malaria and its association with RRT as well as in-hospitalPublication Open Access Laboratory prediction of the requirement for renal replacement in acute falciparum malaria.(2011-08-03) Hanson, Josh; Hasan, Md Mahtab Uddin; Royakkers, Annick A; Alam, Shamsul; Prakaykaew Charunwatthana; ประกายแก้ว จรูญวรรธนะ; Maude, Richard J; Douthwaite, Sam T; Yunus, Emran Bin; Mantha, Murty L; Schultz, Marcus J; Faiz, M Abul; White, Nicholas J; Day, Nicholas P; Dondorp, Arjen M; Hanson, Josh; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit. Shoklo Malaria Research Unit.BACKGROUND: Acute renal failure is a common complication of severe malaria in adults, and without renal replacement therapy (RRT), it carries a poor prognosis. Even when RRT is available, delaying its initiation may increase mortality. Earlier... identification of patients who will need RRT may improve outcomes. METHOD: Prospectively collected data from two intervention studies in adults with severe malaria were analysed focusing on laboratory features on presentation and their association with aPublication Open Access A morphometric and histological study of placental malaria shows significant changes to villous architecture in both Plasmodium falciparum and Plasmodium vivax infection(2014-01-04) Sethawud Chaikitgosiyakul; เสฏฐวุฒิ ชัยกิตโกสิยกุล; Rijken, Marcus J.; Muehlenbachs, Atis; Lee, Sue J.; Urai Chaisri; อุไร ไชยศรี; Parnpen Viriyavejakul; พรรณเพ็ญ วิริยเวชกุล; Turner, Gareth D.; Emsri Pongponratn; เอี่ยมศรี พงศ์พนรัตน์; Nosten, Francois; McGready, Rose; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Research Unit; Mahidol University. Faculty of Tropical Medicine. Department of Tropical PathologyBACKGROUND: Malaria in pregnancy remains a major health problem. Placental malaria infection may cause pathophysiological changes in pregnancy and result in morphological changes to placental villi. Quantitative histomorphological image analysis... of placental biopsies was performed to compare placental villous architecture between active or treated placental malaria cases and controls. METHODS: A total of 67 placentas were studied from three clinical groups: control patients who did not have malariaPublication Open Access Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules(2004-06-25) Nathawut Sibmooh; Paveena Yamanont; Srivicha Krudsood; ศรีวิชา ครุฑสูตร; Wattana Leowattana; วัฒนา เลี้ยววัฒนา; Brittenham, Gary; Sornchai Looareesuwan; ศรชัย หลูอารีย์สุวรรณ; Rachanee Udomsangpetch; Nathawut Sibmooh; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine. Hospital for Tropical Diseases; Mahidol University. Faculty of Science. Department of Pharmacology; Mahidol University. Faculty of Science. Department of PathobiologyINTRODUCTION: Oxidative stress has been demonstrated in malaria. The potential oxidative modification of lipoproteins derived from malaria patients was studied. These oxidized lipids may have role in pathogenesis of malaria. METHOD: The plasma... lipid profile and existence of oxidized forms of very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were investigated in malaria (17 mild and 24 severe patients) and 37 control subjects