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Item Metadata only Biomarkers at 6 weeks' gestation in the prediction of early miscarriage in pregnancy following assisted reproductive technology(2023-01-01) Guo J.; Feng Q.; Chaemsaithong P.; Appiah K.; Sahota D.S.; Leung B.W.; Chung J.P.; Li T.C.; Poon L.C.; Mahidol UniversityIntroduction: Miscarriage is a major concern in early pregnancy among women having conceived with assisted reproductive treatments. This study aimed to examine potential miscarriage-related biophysical and biochemical markers at 6 weeks' gestationItem Metadata only Biomarkers in the prediction of complications in pregnancy after assisted reproductive technology(2024-01-01) Nguyen-Hoang L.; Chaemsaithong P.; Ip P.N.; Guo J.; Wang X.; Chong M.K.C.; Sahota D.S.; Chung J.P.; Poon L.C.; Nguyen-Hoang L.; Mahidol UniversityObjectives: To compare the temporal changes in mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) across gestation between assisted reproductive... technology (ART) pregnancies complicated with great obstetrical syndromes (GOS) or gestational diabetes (GDM) ± large-for-gestational-age (LGA) fetus, and uncomplicated ART pregnancies. Methods: This was a prospective longitudinal study of 143 womenItem Metadata only Ultrasonographic placental parameters at 11–13+6 weeks’ gestation in the prediction of complications in pregnancy after assisted reproductive technology(2024-01-01) Ip P.N.P.; Nguyen-Hoang L.; Chaemsaithong P.; Guo J.; Wang X.; Sahota D.S.; Chung J.P.W.; Poon L.C.Y.; Ip P.N.P.; Mahidol UniversityObjective: To evaluate the performance of maternal factors, biophysical and biochemical markers at 11–13 + 6 weeks’ gestation in the prediction of gestational diabetes mellitus with or without large for gestational age (GDM ± LGA) fetus and great obstetrical syndromes (GOS) among singleton pregnancy following in-vitro fertilisation (IVF)/embryo transfer (ET). Materials and methods: A prospective cohort study was conducted between December 2017 and January 2020 including patients who underwent IVF/ET. Maternal mean arterial pressure (MAP), ultrasound markers including placental volume, vascularisation index (VI), flow index (FI) and vascularisation flow index (VFI), mean uterine artery pulsatility index (mUtPI) and biochemical markers including placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) were measured at 11–13 + 6 weeks’ gestation. Logistic regression analysis was performed to determine the significant predictors of complications. Results: Among 123 included pregnancies, 38 (30.9%) had GDM ± LGA fetus and 28 (22.8%) had GOS. The median maternal height and body mass index were significantly higher in women with GDM ± LGA fetus. Multivariate logistic regression analysis demonstrated that in the prediction of GDM ± LGA fetus and GOS, there were significant independent contributions from FI MoM (area under curve (AUROC) of 0.610, 95% CI 0.492–0.727; p = 0.062) and MAP MoM (AUROC of 0.645, 95% CI 0.510–0.779; p = 0.026), respectively. Conclusion: FI and MAP are independent predictors for GDM ± LGA fetus and GOS, respectively. However, they have low predictive value. There is a need to identify more specific novel biomarkers in differentiating IVF/ET pregnancies that are at a higher risk of developing complications.Item Metadata only Population-based FMR1 carrier screening among reproductive women(2024-01-01) Ain Q.; Hwang Y.H.; Yeung D.; Panpaprai P.; Iamurairat W.; Chutimongkonkul W.; Trachoo O.; Tassone F.; Jiraanont P.; Ain Q.; Mahidol Universityreproductive women at the tertiary hospital. A total of 1250 females participated in this study; ages ranged from 20 to 45 years, mean of 30 years (S.D. = 6.27). Results: Two carriers of a premutation allele, with 32,62 and 32,69 CGG repeats respectively, were... case was detected. Conclusions: This study heightens the importance of PM carrier screening of women of reproductive age, particularly for the higher risk of developing fragile X–associated primary ovarian insufficiency (FXPOI). Early identificationPublication Metadata only Comparison of pregnancy outcomes using a timelapse monitoring system for embryo incubation versus a conventional incubator in in vitro fertilization: An age-stratification analysis(2021-01-01) Pattraporn Chera-aree; Isarin Thanaboonyawat; Benjawan Thokha; Pitak Laokirkkiat; Siriraj Hospital: The medical records of 250 fertilized embryos from 141 patients undergoing infertility treatment with assisted reproductive technology at a tertiary hospital from June 2018 to May 2020 were reviewed. The study population was divided into TLS and CI groups at a... the live birth rate, implantation rate, and clinical pregnancy rate, particularly in the advanced age group in this study, while the other reproductive outcomes were comparable. Large randomized controlled trials are needed to further exploreItem Metadata only Balancing IL-17: Implications for immune tolerance, pregnancy outcomes, and reproductive health(2026-06-01) Soongsathitanon J.; Pongcharoen S.; Soongsathitanon J.; Mahidol Universityas a biomarker and therapeutic target in infertility and assisted reproductive technologies. Understanding the context-dependent actions of IL-17 may provide new opportunities to improve reproductive outcomes and guide future translational research... in reproductive immunology.Publication Metadata only Outcome of pregnancy in IVF-ET cycle at Ramathibodi Hospital.(1995-12-01) C. Srisombut; A. Rojanasakul; C. Suchartwatnachai; W. Choktanasiri; S. Weerakiet; S. Chinsomboon; Mahidol UniversityAs assisted reproductive technology is being developed, in vitro fertilization and embryo transfer (IVF-ET) are the treatments of choice for many infertility problems. The outcome of pregnancies achieved by IVF-ET is different fromPublication Metadata only Serum-free placental growth factor isoform 1 at 11–13-week gestation: effects of maternal factors, mean arterial pressure, placental volume, and uterine artery pulsatility index(2018-11-02) Maolee Bhuwapathanapun; Busadee Pratumvinit; Piyaporn Lahfahroengron; Sithikan Hanyongyuth; Amprapha Phaophan; Julaporn Pooliam; Tuangsit Wataganara; Faculty of Medicine, Siriraj Hospital, Mahidol University, tobacco use, assisted reproductive technology, and body mass index). MAP was measured. Serum-free PlGF-1, PV, and UtAPI were measured with a new assay, transabdominal three-dimensional, and color Doppler ultrasounds, respectively. EffectsItem Metadata only Effect of Intrauterine Autologous Platelet-Rich Plasma Instillation in Infertile Women With Thin Endometrium Undergoing Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial(2025-07-01) Pothisan S.; Laokirkkiat P.; Petyim S.; Thanaboonyawat I.; Prechapanich J.; Humart P.; Teammak P.; Parkpinyo N.; Pothisan S.; Mahidol UniversityBackground: Endometrial thickness is a key factor in determining the suitability for embryo transfer (ET) and influences the success of assisted reproductive technology (ART) outcomes. The aim of this study is to compare endometrial thickness