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Publication Metadata only Consequences of circadian disruption on cardiometabolic health(2015-12-01) Sirimon Reutrakul; Kristen L. Knutson; Mahidol University; University of Chicago© 2015 Elsevier Inc. Cardiovascular disease, diabetes and obesity are highly prevalent diseases associated with reduced quality of life and life expectancy. We discuss a novel risk factor for these cardiometabolic diseases: circadian disruption.... Circadian disruption occurs when the internal circadian (∼24-hour) rhythms are not in synchrony with the environment or each other. This paper reviews (1) cardiometabolic health of shift work, which often leads to circadian disruption, (2) effectsItem Metadata only Compound D from Zingiber cassumunar Roxb. attenuated type 2 inflammatory cytokine-induced tight junction disruption in airway epithelial cells(2025-06-01) Poachanukoon O.; Termworasin P.; Tharabenjasin P.; Dechatiwongse Na Ayudhya T.; Moonwiriyakit A.; Poachanukoon O.; Mahidol UniversityBACKGROUND: Barrier disruption in the airway mucosae has been implicated in allergic type 2 inflammatory diseases such as allergic rhinitis and asthma. Zingiber cassumunar Roxb. has long been used in traditional medicine to treat allergic diseases...-induced barrier disruption. METHODS: Type 2 cytokine (IL-4 and IL-13)-exposed 16HBE human bronchial epithelial cells were treated with compound D. After 24, 48, and 72 h, cytotoxicity, epithelial integrity, and tight junction (TJ) disruption werePublication Metadata only Topical Application of Honey in Treatment of Abdominal Wound Disruption(1992-01-01) Winit Phuapradit; Nopadol Saropala; Mahidol Universityas if the problem was an infected haematoma which is an unusual cause of wound disruption in the editor's experience; yet the authors encountered 15 cases in 19 months, and quoted no case of the complete wound dehiscence referred to above! Summary: The usefulness... of honey application as an alternative method of managing abdominal wound disruption was assessed. Fifteen patients whose wound disrupted after Caesarean section were treated with honey application and wound approximation by micropore tape insteadItem Metadata only Associations between the stringency of COVID-19 containment policies and health service disruptions in 10 countries(2023-12-01) Reddy T.; Kapoor N.R.; Kubota S.; Doubova S.V.; Asai D.; Mariam D.H.; Ayele W.; Mebratie A.D.; Thermidor R.; Sapag J.C.; Bedregal P.; Passi-Solar Á.; Gordon-Strachan G.; Dulal M.; Gadeka D.D.; Mehata S.; Margozzini P.; Leerapan B.; Rittiphairoj T.; Kaewkamjornchai P.; Nega A.; Awoonor-Williams J.K.; Kruk M.E.; Arsenault C.; Mahidol UniversityBackground: Disruptions in essential health services during the COVID-19 pandemic have been reported in several countries. Yet, patterns in health service disruption according to country responses remain unclear. In this paper, we investigate... associations between the stringency of COVID-19 containment policies and disruptions in 31 health services in 10 low- middle- and high-income countries in 2020. Methods: Using routine health information systems and administrative data from 10 countries (ChilePublication Metadata only Pathophysiological mechanisms of diarrhea caused by the Vibrio cholerae O1 El Tor variant: an in vivo study in mice(2016-10-02) Saravut Satitsri; Pawin Pongkorpsakol; Potjanee Srimanote; Varanuj Chatsudthipong; Chatchai Muanprasat; Mahidol University; Thammasat University; Thailand Ministry of Educationsecretion. In addition, barrier disruption and NF-κB-mediated inflammatory responses, e.g., iNOS and COX-2 expression, were observed in the infected ileal loops. Interestingly, intestinal fluid secretion and barrier disruption were suppressed by NF-κB... and COX-2 inhibitors, whereas an iNOS inhibitor suppressed barrier disruption without affecting fluid secretion. Furthermore, EP2 and EP4 PGE2receptor antagonists ameliorated the fluid secretion in the infected ileal loops. The amount of cholera toxin (CTPublication Metadata only Pharmacological stimulation of G–protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells(2019-08-01) Aekkacha Moonwiriyakit; Michael Koval; Chatchai Muanprasat; Mahidol University; Emory University School of Medicineto inflammatory insults are unknown. This study was aimed to investigate the effect of GPR40 stimulation on proinflammatory cytokine (TNFα and IL–1β)-induced tight junction disruption in human airway epithelial Calu–3 cells using GW9508, a GPR40 agonist. We found...B indicated that GW9508 had no effect on cytokine-induced NF–ĸB activation. Intriguingly, GW9508 inhibited cytokine-induced airway epithelial barrier disruption through suppression of extracellular signal–regulated kinase (ERK) phosphorylation in aPublication Metadata only Complex lumbosacral fracture-dislocation with pelvic ring disruption and vertical shear sacral fracture: A case report of late presentation and review of the literature(2010-11-01) Chayanin Angthong; Somyot Wunnasinthop; Sanyapong Sanpakit; Mahidol UniversityCombination of lumbosacral junction injury with closed vertical shear sacral fracture and disruption of the symphysis pubis is a very rare pattern of injury, particularly with a late presentation. To our knowledge, the complexity of such a..., pelvic ring disruption and a vertical shear sacral fracture with neurological deficits and to emphasize the difficulties in the management in this case and the operative technique used for the definitive treatment. The initial event had occurred threePublication Metadata only Selective disruption of heparin and antithrombin-mediated regulation of human factor IX(2015-01-01) P. R. Westmark; P. Tanratana; J. P. Sheehan; University of Wisconsin Madison; Mahidol Universityextravascular FIX, which colocalizes with antithrombin-heparan sulfate. Objective: Combined mutagenesis of FIX was undertaken to selectively disrupt heparin- and antithrombin-mediated regulation of the protease. Methods: Human FIX alanine substitutions.... The half-life of FIXa WT in FIX-deficient plasma was remarkably lengthy (40.9 ±1.4 min) and further prolonged for FIXa R150A, K126A/R150A, and K132A/R150A (> 2 h). Conclusion: Selective disruption of exosite-mediated regulation by heparin and antithrombinPublication Metadata only Surgical treatment of internal disc disruption: An outcome study of four fusion techniques(1998-11-10) Visit Vamvanij; Bruce E. Fredrickson; Joshua M. Thorpe; Michael E. Stadnick; Hansen A. Yuan; Mahidol University; State University of New York Upstate Medical University; Institute for Spine CareSurgical treatment for internal disc disruption remains controversial in terms of efficacy of spinal fusion and optimal fusion method. The present study was carried out in 56 consecutive patients, with the diagnosis confirmed by computed tomographicItem Metadata only The Effects of PP2A Disruption on ER-Mitochondria Contact and Mitochondrial Functions in Neuronal-like Cells(2023-04-01) Chaiwijit P.; Uppakara K.; Asavapanumas N.; Saengsawang W.; Mahidol University2A inhibition, which correlated with elevated mitochondrial Ca2+ influx and disrupted mitochondrial membrane potential and mitochondrial fission. This study highlights the essential role PP2A plays in regulating MAM formation and mitochondrial