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Publication Metadata only Chemotherapy of cerebral malaria: Current recommendations for treatment and prophylaxis(1997-01-01) Polrat Wilairatana; Sornchai Looareesuwan; Douglas S. Walsh; Mahidol University; Armed Forces Research Institute of Medical Sciences, Thailandof cerebral disease is characterised by complex host-parasite interactions. Optimal management of cerebral malaria is also complex, requiring accurate diagnosis, prompt treatment with one of the few remaining effective antimalarial drugs, and recognition..., chemoprophylaxis may reduce the subsequent risk of cerebral malaria if a 'breakthrough' falciparum infection is acquired. Additionally, early diagnosis and prompt treatment of individuals with uncomplicated falciparum malaria may diminish the risk of cerebralPublication Metadata only Overview: pathophysiology and management of cerebral malaria.(1992-09-01) S. Looareesuwan; Mahidol Universityin cerebral capillaries and venules. Three possible mechanisms of sequestration (cytoadherence, rosette formation and decreased deformability of the infected erythrocytes) are postulated. The management of cerebral malaria includes early diagnosis and early...Cerebral malaria is still a major cause of death in patients suffering from malaria. Much of the research work in the past two decades has been done to clarify the pathophysiology of cerebral malaria which hopes to improve the managementPublication Metadata only Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria(2018-02-01) Katherine Plewes; Gareth D.H. Turner; Arjen M. Dondorp; Mahidol University; The University of British Columbia; Nuffield Department of Clinical Medicine; John Radcliffe Hospitalis involved in cerebral malaria. Summary The direct causes of cerebral and kidney dysfunction remain incompletely understood. Optimal treatment involves prompt diagnosis and effective antimalarial treatment with artesunate. Renal replacement therapy reduces...© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. Purpose of review Cerebral impairment and acute kidney injury (AKI) are independent predictors of mortality in both adults and children with severe falciparum malaria. In this review, wePublication Metadata only Pulmonary edema in cerebral malaria patients in Thailand(1998-09-01) Boonrut Aursudkij; Polrat Wilairatana; Suparp Vannaphan; Douglas S. Walsh; Victor R. Gordeux; Sornchai Looareesuwan; Mahidol University; Armed Forces Research Institute of Medical Sciences, Thailand; George Washington University Medical CenterPulmonary edema is a serious complication of falciparum malaria that usually occurs in association with cerebral malaria, acute renal failure, high parasitemias, or delayed antimalarial treatment. From 1993 to 1996, 120 adult patients admitted... to the intensive care unit of the Bangkok Hospital for Tropical Diseases were enrolled in a prospective study to assess the combination of artesunate and mefloquine for the treatment of cerebral malaria. Twenty-five patients (21%) presented with pulmonary edemaPublication Metadata only Sequestration and microvascular congestion are associated with coma in human cerebral malaria(2012-02-15) Mark J. Ponsford; Isabelle M. Medana; Panote Prapansilp; Tran Tinh Hien; Sue J. Lee; Arjen M. Dondorp; Margaret M. Esiri; Nicholas P J Day; Nicholas J. White; Gareth D H Turner; Nuffield Department of Clinical Medicine; University of Oxford; Mahidol University; UCLto coma in cerebral malaria. Quantitative postmortem microscopy of brain sections from Vietnamese adults dying of malaria confirmed that sequestration in the cerebral microvasculature was significantly higher in patients with cerebral malaria (CM; n = 21...The pathogenesis of coma in severe Plasmodium falciparum malaria remains poorly understood. Obstruction of the brain microvasculature because of sequestration of parasitized red blood cells (pRBCs) represents one mechanism that could contributePublication Metadata only Malarial retinopathy in Bangladeshi adults(2011-01-01) Abdullah Abu Sayeed; Richard J. Maude; Mahtab Uddin Hasan; Noor Mohammed; M. Gofranul Hoque; Arjen M. Dondorp; M. Abul Faiz; Chittagong Medical College Hospital; Mahidol University; Sir Salimullah Medical Collegeophthalmoscopy by non-ophthalmologists is an important clinical tool to aid diagnosis and prognosis in adults with severe malaria, and indirect ophthalmoscopy by non-ophthalmologists, although more sensitive, provides minimal additional prognostic information...To establish if assessment of malarial retinopathy in adult malaria using ophthalmoscopy by non-ophthalmologists has clinical and prognostic significance, 210 Bangladeshi adults were assessed by both direct and indirect ophthalmoscopy; 20 of 20Publication Metadata only Management of severe malarial infection(1989-03-01) Sanjeev Krishna; Nicholas J. White; John Radcliffe Hospital; Mahidol UniversitySevere malaria is a major cause of infant and childhood death in the tropics. Effective management relies on rapid diagnosis, prompt administration of parenteral schizonticidal antimalarial drugs, careful fluid balance, prevention of convulsions... and early recognition of complications such as hypoglycemia, metabolic acidosis, anemia, pulmonary edema, renal failure, bleeding and supervening bacterial sepsis. The mortality of treated cerebral malaria remains 20%. New, more rapidly acting antimalarialsPublication Metadata only The epidemiology of severe malaria in an area of low transmission in Thailand(1997-01-01) Christine Luxemburger; Françoise Ricci; François Nosten; Dominique Raimond; Saw Bathet; Nicholas J. White; Shoklo Malaria Research Unit; Mahidol University; Medecins Sans Frontieres; John Radcliffe Hospitalinfection per person per year), where asymptomatic malaria is unusual. In, a population of 4728 persons, who had good access to facilities for malaria diagnosis and treatment, there were 2573 cases of vivax malaria, none of whom died, and there were 5776.... The clinical features of severe malaria differed between children and adults. Anaemia was more common in children under 5 years old than in older children and adults, whereas the incidence of cerebral involvement increased with age. Severe malaria was 3 times