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Subject: Medicine

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    Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01
    (2021-04-29) Jirawat Pratoomwun; Paul Thomson; Kanoot Jaruthamsophon; Rawiporn Tiyasirichokchai; Pimonpan Jinda; Ticha Rerkpattanapipat; Wichittra Tassaneeyakul; Nontaya Nakkam; Pawinee Rerknimitr; Jettanong Klaewsongkram; Yuttana Srinoulprasert; Munir Pirmohamed; Dean J. Naisbitt; Chonlaphat Sukasem; Ramathibodi Hospital; Siriraj Hospital; Chulalongkorn University; Faculty of Medicine, Khon Kaen University; University of Liverpool; Faculty of Medicine Ramathibodi Hospital, Mahidol University; Huachiew Chalermprakiet University; Prince of Songkla University; Faculty of Medicine, Chulalongkorn University
    syndrome or drug reaction with eosinophilia and systemic symptoms. Two of the patients carried the HLA allele of interest, namely HLA-B*13:01. Sulfamethoxazole and nitroso sulfamethoxazole specific T cell clones were generated from T cell lines of co...-trimoxazole hypersensitive HLA-B*13:01-positive patients. Clones were characterized for antigen specificity and cross-reactivity with structurally related compounds by measuring proliferation and cytokine release. Surface marker expression was characterized
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    Genistein enhances N-nitrosomethylurea-induced rat mammary tumorigenesis
    (2006-10-08) Pisamai Kijkuokool; Ishwar S. Parhar; Suchinda Malaivijitnond; Mahidol University; Chulalongkorn University; Nippon Medical School
    Genistein is of great interest for its implications as an anticancer compound. We compared the effects of daily subcutaneous injections of 1 mg/kg BW of genistein and vehicle (2% DMSO in peanut oil) for 20 weeks on N-nitroso-N-methylurea (NMU