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Publication Metadata only Effects of social isolation rearing on learning in the Morris water maze(1996-04-09) Noppamars Wongwitdecha; Charles Alexander Marsden; University of Nottingham; Mahidol Universityexperiments investigated the effects of isolation rearing on place navigation in the Morris water maze. Two complementary paradigms were studied: isolation and socially reared rats were exposed to the water maze either without drug pretreatment or following... later place learning and reversal learning were determined using the Morris water maze. The time taken to locate the submerged island (escape latency) was used as the measure of learning ability. The results showed that place learning, and reversalPublication Metadata only Reversible short-term and delayed long-term cognitive impairment induced by chronic mild cerebral hypoperfusion in rats(2013-08-01) Khwanjai Thong-Asa; Supin Chompoopong; Mayuree H. Tantisira; Kanokwan Tilokskulchai; Mahidol University; Kasetsart University; Chulalongkorn University; Burapha University) were evaluated repeatedly by the radial arm water maze at 6 days, and 1, 2 and 4 months after surgery. The spatial performance was re-assessed by the Morris water maze when the rats were 18 months old. The present results revealed that the rCCAO ratsPublication Metadata only Neuroprotective effects of quercetin, rutin and okra (Abelmoschus esculentus Linn.) in dexamethasone-treated mice(2011-10-01) Walaiporn Tongjaroenbuangam; Nootchanart Ruksee; Piyanete Chantiratikul; Noppakun Pakdeenarong; Watee Kongbuntad; Piyarat Govitrapong; Mahasarakham University; Mahidol Universityusing the Morris water maze test. The results showed that the mice treated with dexamethasone had prolonged water maze performance latencies and shorter time spent in the target quadrant while mice pretreated with quercetin, rutin or okra extract priorPublication Metadata only Melatonin attenuates dexamethasone-induced spatial memory impairment and dexamethasone-induced reduction of synaptic protein expressions in the mouse brain(2013-10-01) Walaiporn Tongjaroenbuangam; Nootchanart Ruksee; Thanutchaporn Mahanam; Piyarat Govitrapong; Mahasarakham University; Mahidol Universityshowed that mice treated with DEX for 21 consecutive days had significantly impaired spatial memory in the Morris Water Maze task. Mice treated with DEX had prolonged water maze performance latencies and spent less time in the target quadrant comparedPublication Metadata only The activating transcription factor 3 (Atf3) homozygous knockout mice exhibit enhanced conditioned fear and down regulation of hippocampal GELSOLIN(2018-02-20) Chia Sheng Pai; Pranao K. Sharma; Hsien Ting Huang; Srivaishnavi Loganathan; Heng Lin; Yu Luan Hsu; Sarayut Phasuk; Ingrid Y. Liu; Taipei Medical University; Tzu Chi University; Faculty of Medicine, Siriraj Hospital, Mahidol University; Max Planck Institut für Psychiatrie. The results demonstrated that the lack of ATF3 specifically enhanced the expression of fear memory, which was indicated by a higher incidence of the freeze response after fear conditioning, whereas the occurrence of spatial memory including Morris Water Maze... and radial arm maze remained unchanged. The enhanced freezing behavior and normal spatial memory of the Atf3 knockout mice resembles the fear response and numbing symptoms often exhibited by patients affected with posttraumatic stress disorder. AdditionallyPublication Metadata only Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity(2021-12-01) Sarayut Phasuk; Sureka Jasmin; Tanita Pairojana; Hsueh Kai Chang; Kai Chi Liang; Ingrid Y. Liu; Siriraj Hospital; Academia Sinica, Institute of Biomedical Sciences; Tzu Chi Universityrole in spatial memory has not been investigated yet. This study aims to explore the function of the Prdx6 gene in spatial memory formation and synaptic plasticity. We first tested Prdx6−/− mice on a Morris water maze task and found that their memoryPublication Metadata only Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats(2020-01-01) Utcharaporn Kamsrijai; Prapimpun Wongchitrat; Chutikorn Nopparat; Jutamaad Satayavivad; Piyarat Govitrapong; Chulabhorn Research Institute; Mahidol University; Chulabhorn Royal Academyof streptozotocin (60 mg/kg STZ) was intraperitoneally injected. Morris water maze, Western blot and immunohistochemistry analysis of proteins in the hippocampus were measured. We found that melatonin was effective in protecting against memory impairmentPublication Metadata only Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus(2021-12-20) Thit Lwin; Jenq Lin Yang; Sukonthar Ngampramuan; Kittikun Viwatpinyo; Pongrung Chancharoen; Nisarath Veschsanit; Jitrapa Pinyomahakul; Piyarat Govitrapong; Sujira Mukda; Chang Gung Memorial Hospital; Chulabhorn Royal Academy; Mahidol University; Institute of Molecular Biosciences, Mahidol University; Burapha University; Mingalardonmanner comparable to the anti-inflammatory agent, minocycline, with consequent improvements of METH-induced cognitive impairments and associated abnormalities in the mouse hippocampus. Results from the Morris water maze (MWM) test and the novel objectItem Metadata only Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice(2024-12-01) Nehra G.; Promsan S.; Yubolphan R.; Chumboatong W.; Vivithanaporn P.; Maloney B.J.; Lungkaphin A.; Bauer B.; Hartz A.M.S.; Nehra G.; Mahidol University5xFAD mice to investigate changes in Aβ levels, barrier function, and cognitive decline over time. Methods: 5xFAD and wild-type (WT) mice were aged between 9.5 and 15.5 months and tested for spatial learning and reference memory with the Morris Water... Maze (MWM). After behavior testing, mice were implanted with acute cranial windows and intravenously injected with fluorescent-labeled dextrans to assess their in vivo distribution in the brain by two-photon microscopy. Images were processedItem Metadata only Piracetam attenuates oxidative stress and inflammation-induced neuronal cell death in rats with vascular dementia potentially via the activation of the AMPK/SIRT-1/Nrf-2 signaling pathway(2025-12-01) Thangwong P.; Sengking J.; Promyoo N.; Saephu M.; Jearjaroen P.; Khamchai S.; Punsawad C.; Tocharus C.; Tocharus J.; Thangwong P.; Mahidol University, cognitive performance was assessed using the Morris water maze test. Then biochemical analyses, including Western blotting and immunohistochemistry, were performed to assess markers of oxidative stress, neuroinflammation, pyroptosis, and necroptosis. Our