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Publication Open Access Effect of the shades of background substructures on the overall color of zirconia-based all-ceramic crowns.(2013-08) Kallaya Suputtamongkol; กัลยา ศุพุทธมงคล; Chantana Tulapornchai; ฉันทนา ตุลาพรชัย; Jatuphol Mamani; Wannaporn Kamchatphai; วรรณพร กำจัดภัย; Noparat Thongpun; นพรัตน์ ทองพันธ์; Kallaya Suputtamongkol; กัลยา ศุพุทธมงคล; Mahidol University. Faculty of Dentistry. Prosthodontics Department, with different core thicknesses (0.4-1 mm) were also prepared to obtain the contrast ratio of zirconia materials after veneering. RESULTS: L(*) , a(*) , and b(*) values of all-ceramic crowns cemented either on a metal cast post and core or on a prefabricated post.... CONCLUSION: No significant differences were observed between the L(*) , a(*) , and b(*) values of zirconia crowns cemented either on a metal cast post and core or a prefabricated post and composite core. However, the color of a background substructure couldPublication Open Access The potential of copper alloy as alternative material for post and core applications.(2014-09) Somchai Urapepon; สมชาย อุรพีพล; Usanee Peungpaiboon; อุษณีย์ ปึงไพบูลย์; Somchai Urapepon; สมชาย อุรพีพล; Mahidol University. Faculty of Dentistry. Department of Prosthodonticsthan that of the Cu-Al-Ni alloy. Conclusion: Regarding mechanical properties, Cu-Al alloy seemed the most suitable for post and core materials while Cu-Al-Ni alloy had the highest corrosion resistance. Thus, both Cu-Al and Cu-Al-Ni alloys showed... promising properties for further development as appropriate post-and-core materials.Publication Open Access Tensile strength of bilayered ceramics and corresponding glass veneers.(2014-06) Chuchai Anunmana; ชูชัย อนันต์มานะ; Tharee Champirat; ธารี จำปีรัตน์; Bundhit Jirajariyavej; บัณฑิต จิรจริยาเวช; Chuchai Anunmana; ชูชัย อนันต์มานะ; Mahidol University. Faculty of Dentistry. Department of Prosthodontics; Mahidol University. Faculty of Dentistry. Department of Advanced General DentistryPURPOSE: To investigate the microtensile bond strength between two all-ceramic systems; lithium disilicate glass ceramic and zirconia core ceramics bonded with their corresponding glass veneers. MATERIALS AND METHODS: Blocks of core ceramics (IPSPublication Open Access The effect of thickness on the contrast ratio and color of veneering ceramics.(2014-05) Phira Sithiamnuai; พีระ สิทธิอำนวย; Trinuch Eiampongpaiboon; ตรีนุช เอี่ยมพงษ์ไพบูลย์; Shrestha, Arati; Kallaya Suputtamongkol; กัลยา ศุพุทธมงคล; Kallaya Suputtamongkol; กัลยา ศุพุทธมงคล; Mahidol University. Faculty of Dentistry. Department of Prosthodonticsas an increase in ∆E* value.Publication Open Access Thermoregulatory correlates of nausea in rats and musk shrews(2014) Sukonthar Ngampramuan; Matteo Cerri; Flavia Del Vecchio; Corrigan, Joshua J; Amornrat Kamphee; Dragic, Alexander S; Rudd, John A; Romanovsky, Andrej A; Eugene Nalivaiko; Mahidol University. Institute of Molecular BiosciencesNausea is a prominent symptom and major cause of complaint for patients receiving anticancer chemo- or radiation therapy. The arsenal of anti-nausea drugs is limited, and their efficacy is questionable. Currently, the development of new compounds with anti-nausea activity is hampered by the lack of physiological correlates of nausea. Physiological correlates are needed because common laboratory rodents lack the vomiting reflex. Furthermore, nausea does not always lead to vomiting. Here, we report the results of studies conducted in four research centers to investigate whether nausea is associated with any specific thermoregulatory symptoms. Two species were studied: the laboratory rat, which has no vomiting reflex, and the house musk shrew (Suncus murinus), which does have a vomiting reflex. In rats, motion sickness was induced by rotating them in their individual cages in the horizontal plane (0.75 Hz, 40 min) and confirmed by reduced food consumption at the onset of dark (active) phase. In 100% of rats tested at three centers, postrotational sickness was associated with marked (~1.5°C) hypothermia, which was associated with a short-lasting tail-skin vasodilation (skin temperature increased by ~4°C). Pretreatment with ondansetron, a serotonin 5-HT3 receptor antagonist, which is used to treat nausea in patients in chemo- or radiation therapy, attenuated hypothermia by ~30%. In shrews, motion sickness was induced by a cyclical backand-forth motion (4 cm, 1 Hz, 15 min) and confirmed by the presence of retching and vomiting. In this model, sickness was also accompanied by marked hypothermia (~2°C). Like in rats, the hypothermic response was preceded by transient tail-skin vasodilation. In conclusion, motion sickness is accompanied by hypothermia that involves both autonomic and thermoeffector mechanisms: tail-skin vasodilation and possibly reduction of the interscapular brown adipose tissue activity. These thermoregulatory symptoms may serve as physiological correlates of nausea.Publication Open Access Interfacial toughness of bilayer dental ceramics based on a short-bar, chevron-notch test.(2010-02) Chuchai Anunmana; ชูชัย อนันต์มานะ; Anusavice, Kenneth J.; Mecholsky, Jr., John J.; Mahidol University. Faculty of Dentistry. Department of ProsthodonticsObjective—The objective of this study was to test the null hypothesis that the interfacial toughness of each of two types of bonded core-veneer bilayer ceramics is not significantly different from the apparent fracture toughness of the control... monolithic glass veneer. Methods—T-shaped short bars of a lithia-disilicate glass-ceramic core (LC) and yttria-stabilized polycrystalline zirconia core ceramic (ZC) were prepared according to the manufacturer's recommendations. V-shaped notches were preparedPublication Open Access Clinical performance and failures of zirconia-based fixed partial dentures: a review literature.(2012-05) Premwara Triwatana; เปรมวรา ตรีวัฒนา; Noppavan Nagaviroj; นพวรรณท์ นาควิโรจน์; Chantana Tulapornchai; ฉันทนา ตุลาพรชัย; Chantana Tulapornchai; Mahidol University. Faculty of Dentistry. Department of ProsthodonticsFPDs ranged between 73.9% - 100% after 2 - 5 years. The causes of failure were veneer fracture, ceramic core fracture, abutment tooth fracture, secondary caries, and restoration dislodgment. CONCLUSION. The overall performance of zirconia FPDs... was satisfactory according to either USPHS criteria or CDA evaluations. Fracture resistance of core and veneering ceramics, bonding between core and veneering materials, and marginal discrepancy of zirconia-based restorations were discussed as the causesPublication Open Access Discovery of novel 1,2,3-triazole derivatives as anticancer agents using QSAR and in silico structural modification(2015-10-05) Veda Prachayasittikul; Ratchanok Pingaew; Nuttapat Anuwongcharoen; Apilak Worachartcheewan; Chanin Nantasenamat; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical InformaticsConsiderable attention has been given on the search for novel anticancer drugs with respect to the disease sequelae on human health and well-being. Triazole is considered to be an attractive scaffold possessing diverse biological activities. Structural modification on the privileged structures is noted as an effective strategy towards successful design and development of novel drugs. The quantitative structure–activity relationships (QSAR) is well-known as a powerful computational tool to facilitate the discovery of potential compounds. In this study, a series of thirty-two 1,2,3-triazole derivatives (1–32) together with their experimentally measured cytotoxic activities against four cancer cell lines i.e., HuCCA-1, HepG2, A549 and MOLT-3 were used for QSAR analysis. Four QSAR models were successfully constructed with acceptable predictive performance affording RCV ranging from 0.5958 to 0.8957 and RMSE CV ranging from 0.2070 to 0.4526. An additional set of 64 structurally modified triazole compounds (1A–1R, 2A–2R, 7A–7R and 8A–8R) were constructed in silico and their predicted cytotoxic activities were obtained using the constructed QSAR models. The study suggested crucial moieties and certain properties essential for potent anticancer activity and highlighted a series of promising compounds (21, 28, 32, 1P, 8G, 8N and 8Q) for further development as novel triazole-based anticancer agents.Publication Open Access Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I(2014) Krittikorn Kümpornsin; Namfon Kotanan; Pornpimol Chobson; Theerarat Kochakarn; Piyaporn Jirawatcharadech; Peera Jaru-ampornpan; Yongyuth Yuthavong; Thanat Chookajorn; Mahidol University. Faculty of Science. Department of Biochemistrythat the conserved core domain of GCH1 is responsible for its enzymatic activity. Homology modelling fits P. falciparum GCH1 into the classic Tunnelling-fold structure with well-conserved catalytic residues at the active site. Conclusions: Functional assays for PPublication Open Access Comparative analysis of sugarcane bagasse metagenome reveals unique and conserved biomass-degrading enzymes among lignocellulolytic microbial communities(2015) Wuttichai Mhuantong; Varodom Charoensawan; Pattanop Kanokratana; Sithichoke Tangphatsornruang; Verawat Champreda; Mahidol University. Faculty of Science. Department of Biochemistrymetagenomes show that microbial communities are taxonomically separable by their aerobic “open” or anoxic “closed” environments. Importantly, a functional analysis of lignocellulose-active genes (based on the CAZy classifications) reveals core enzymes... highly conserved within the lignocellulolytic group, regardless of their taxonomic compositions. Cellulases, in particular, are markedly more pronounced compared to the non-lignocellulolytic group. In addition to the core enzymes, the bagasse fosmid