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Item Metadata only Imaging of complications following treatment with assisted reproductive technology: keep on your radar at each step(2022-01-01) Srisajjakul S.; Mahidol UniversitySince the advent of assisted reproductive technology (ART), the utilization of ART procedures has become increasingly popular among women seeking to establish pregnancy. Radiologists are therefore likely to encounter the various complications of ART... of an additional imaging modality, such as computed tomography or magnetic resonance imaging, as a problem-solving tool. This article briefly discusses the steps involved in assisted reproduction. Its aim is to help radiologists become familiarizedItem Metadata only Biomarkers at 6 weeks' gestation in the prediction of early miscarriage in pregnancy following assisted reproductive technology(2023-01-01) Guo J.; Feng Q.; Chaemsaithong P.; Appiah K.; Sahota D.S.; Leung B.W.; Chung J.P.; Li T.C.; Poon L.C.; Mahidol UniversityIntroduction: Miscarriage is a major concern in early pregnancy among women having conceived with assisted reproductive treatments. This study aimed to examine potential miscarriage-related biophysical and biochemical markers at 6 weeks' gestationItem Metadata only Biomarkers in the prediction of complications in pregnancy after assisted reproductive technology(2024-01-01) Nguyen-Hoang L.; Chaemsaithong P.; Ip P.N.; Guo J.; Wang X.; Chong M.K.C.; Sahota D.S.; Chung J.P.; Poon L.C.; Nguyen-Hoang L.; Mahidol UniversityObjectives: To compare the temporal changes in mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) across gestation between assisted reproductive... technology (ART) pregnancies complicated with great obstetrical syndromes (GOS) or gestational diabetes (GDM) ± large-for-gestational-age (LGA) fetus, and uncomplicated ART pregnancies. Methods: This was a prospective longitudinal study of 143 womenItem Metadata only Ultrasonographic placental parameters at 11–13+6 weeks’ gestation in the prediction of complications in pregnancy after assisted reproductive technology(2024-01-01) Ip P.N.P.; Nguyen-Hoang L.; Chaemsaithong P.; Guo J.; Wang X.; Sahota D.S.; Chung J.P.W.; Poon L.C.Y.; Ip P.N.P.; Mahidol UniversityObjective: To evaluate the performance of maternal factors, biophysical and biochemical markers at 11–13 + 6 weeks’ gestation in the prediction of gestational diabetes mellitus with or without large for gestational age (GDM ± LGA) fetus and great obstetrical syndromes (GOS) among singleton pregnancy following in-vitro fertilisation (IVF)/embryo transfer (ET). Materials and methods: A prospective cohort study was conducted between December 2017 and January 2020 including patients who underwent IVF/ET. Maternal mean arterial pressure (MAP), ultrasound markers including placental volume, vascularisation index (VI), flow index (FI) and vascularisation flow index (VFI), mean uterine artery pulsatility index (mUtPI) and biochemical markers including placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) were measured at 11–13 + 6 weeks’ gestation. Logistic regression analysis was performed to determine the significant predictors of complications. Results: Among 123 included pregnancies, 38 (30.9%) had GDM ± LGA fetus and 28 (22.8%) had GOS. The median maternal height and body mass index were significantly higher in women with GDM ± LGA fetus. Multivariate logistic regression analysis demonstrated that in the prediction of GDM ± LGA fetus and GOS, there were significant independent contributions from FI MoM (area under curve (AUROC) of 0.610, 95% CI 0.492–0.727; p = 0.062) and MAP MoM (AUROC of 0.645, 95% CI 0.510–0.779; p = 0.026), respectively. Conclusion: FI and MAP are independent predictors for GDM ± LGA fetus and GOS, respectively. However, they have low predictive value. There is a need to identify more specific novel biomarkers in differentiating IVF/ET pregnancies that are at a higher risk of developing complications.Publication Metadata only An aromatic cluster in Lysinibacillus sphaericus BinB involved in toxicity and proper in-membrane folding(2018-12-15) Sivadatch Chooduang; Wahyu Surya; Jaume Torres; Panadda Boonserm; Mahidol University; Nanyang Technological University; Jetanin Institute for Assisted Reproduction© 2018 Elsevier Inc. The binary toxin from Lysinibacillus sphaericus has been successfully used for controlling mosquito-transmitted diseases. Based on structural alignments with other toxins, an aromatic cluster in the C-terminal domain of BinB (termed here BC) has been proposed to be important for toxicity. We tested this experimentally using BinB mutants bearing single mutations in this aromatic cluster. Consistent with the hypothesis, two of these mutations, F311A and F315A, were not toxic to Culex quinquefasciatus larvae and were unable to permeabilize liposomes or elicit ion channel activity, in contrast to wild-type BinB. Despite these effects, none of these mutations altered significantly the interaction between the activated forms of the two subunits in solution. These results indicate that these aromatic residues on the C-terminal domain of BinB are critical for toxin insertion in membranes. The latter can be by direct contact of these residues with the membrane surface, or by facilitating the formation a membrane-inserting oligomer.Publication Open Access จากพื้นฐานสู่ความก้าวหน้าของการรักษาภาวะมีบุตรยาก(2560) ชลธิชา สถิระพจน์; วิชาญ โชคธนะศิริ; Chonthicha Satirapod; Wicharn Choktanasiri; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. ภาควิชาสูติศาสตร์-นรีเวชวิทยาreproductive technology is used to assist in the treatment of infertility and to increase the rate of pregnancy, including In-Vitro Fertilization (IVF), Intra-cytoplasmic Sperm Injection (ICSI). Moreover the assisted reproductive technology has led.... The success rate for treating infertility depends on the cause of infertility. Therefore, it is important to prioritize the assessment of spouses before treatment to find out the cause of infertility completely female and male. Currently, the assistedItem Unknown Economic evaluation of sterilization reversal in infertility treatment: A systematic review(2026-06-01) Chongthanadon B.; Untaaveesup S.; Kositamongkol C.; Phisalprapa P.; Panyakhamlerd K.; Titapant V.; Chongthanadon B.; Mahidol University-effectiveness or reported the costs of sterilization reversal in males (vasectomy reversal) or females (tubal anastomosis), with assisted reproductive technologies as comparators. Study quality was assessed using the Consolidated Health Economic Evaluation... costs for sterilization reversal than for assisted reproductive technologies, with comparable outcomes. Vasectomy reversal was preferred for male patients irrespective of the female partner’s age, whereas tubal anastomosis was preferred for femaleItem Metadata only ประสบการณ์การมีบุตรยากและการเข้ารับบริการช่วยการเจริญพันธุ์ของผู้หญิงไทย(มหาวิทยาลัยมหิดล. หอสมุดและคลังความรู้มหาวิทยาลัยมหิดล, 2560) นฤมล เจริญใจ; กนกวรรณ ธราวรรณ; พิมพวัลย์ บุญมงคลTechnologies Act 2015" in order to regulate the advanced reproductive technology and protect rights of children who were born from assisted reproductive technology. However, the law does not concern a single woman and the transgender. Thailand currently...The research investigated experience in infertility and the usage of reproductive technology among Thai Women. Qualitative methodological approach, particularly phenomenological approach, was implemented in research design. Observation, informalItem Metadata only Population-based FMR1 carrier screening among reproductive women(2024-01-01) Ain Q.; Hwang Y.H.; Yeung D.; Panpaprai P.; Iamurairat W.; Chutimongkonkul W.; Trachoo O.; Tassone F.; Jiraanont P.; Ain Q.; Mahidol Universityreproductive women at the tertiary hospital. A total of 1250 females participated in this study; ages ranged from 20 to 45 years, mean of 30 years (S.D. = 6.27). Results: Two carriers of a premutation allele, with 32,62 and 32,69 CGG repeats respectively, were... case was detected. Conclusions: This study heightens the importance of PM carrier screening of women of reproductive age, particularly for the higher risk of developing fragile X–associated primary ovarian insufficiency (FXPOI). Early identificationPublication Metadata only Comparison of pregnancy outcomes using a timelapse monitoring system for embryo incubation versus a conventional incubator in in vitro fertilization: An age-stratification analysis(2021-01-01) Pattraporn Chera-aree; Isarin Thanaboonyawat; Benjawan Thokha; Pitak Laokirkkiat; Siriraj Hospital: The medical records of 250 fertilized embryos from 141 patients undergoing infertility treatment with assisted reproductive technology at a tertiary hospital from June 2018 to May 2020 were reviewed. The study population was divided into TLS and CI groups at a... the live birth rate, implantation rate, and clinical pregnancy rate, particularly in the advanced age group in this study, while the other reproductive outcomes were comparable. Large randomized controlled trials are needed to further explore