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Item Open Access Identification of peptides for immune activation and responses in Thai patients with systemic sclerosis(Mahidol University, 2020) Oranit Likhit; Kobporn Boonnak; Sa-nga Pattanakitsakul; Watip TangjittipokinSystemic sclerosis (SSc), or scleroderma, is a chronic autoimmune disease involving a multisystem disorder characterized by skin and visceral organ fibrosis (such as heart, lungs, kidneys, gastrointestinal tract, and musculoskeletal systems.... The etiology of SSc remains unknown but genetics, environmental factors, and immunological abnormalities have been found to contribute to the disease development. This study aims to investigate the role of CD4 + and CD8 + T cells on pathogenesis of systemicPublication Metadata only Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy(2021-12-01) Aulia Rahmi Pawestri; Niracha Arjkongharn; Ragkit Suvannaboon; Aekkachai Tuekprakhon; Vichien Srimuninnimit; Suthipol Udompunthurak; La ongsri Atchaneeyasakul; Ajchara Koolvisoot; Adisak Trinavarat; Siriraj Hospital; Brawijaya University; Nuffield Department of MedicineAutoimmune retinopathy (AIR) is a rare immune-mediated inflammation of the retina. The autoantibodies against retinal proteins and glycolytic enzymes were reported to be involved in the pathogenesis. This retrospective cohort study assessed... nyctalopia (65.9%), blurred vision (52.3%), constricted visual field (43.2%), and nonrecordable electroretinography (65.9%). Underlying malignancy and autoimmune diseases were found in 2 and 12 female patients, respectively. We found 41 autoantibodiesPublication Metadata only Vesiculobullous diseases in relation to lupus erythematosus(2019-01-01) Suthinee Rutnin; Kumutnart Chanprapaph; Faculty of Medicine, Ramathibodi Hospital, Mahidol University. Herein, we thoroughly review the topic of vesiculobullous skin disorders that can be encountered in LE patients and organize them into four groups: LE-specific and aspecific vesiculobullous diseases, LE-related autoimmune bullous diseases, and LE... in association to non-autoimmune conditions. We sought to provide an updated overview highlighting the pathogenesis, clinical, histological, and immunopathological features, laboratory findings, and treatments and prognosis among vesiculobullous conditions in LE.Publication Metadata only Association of HLA and T-cell receptor gene polymorphisms with semple rabies vaccine-induced autoimmune encephalomyelitis(1999-01-01) Sucheep Piyasirisilp; Barbara J. Schmeckpeper; Dasnayanee Chandanayingyong; Thiravat Hemachudha; Diane E. Griffin; Johns Hopkins University; The Johns Hopkins School of Medicine; Mahidol University; Chulalongkorn Universityresponse to myelin basic protein and pathological changes of demyelination in SAE suggest that this disease is the human homologue of experimental autoimmune encephalomyelitis (EAE). SAE and EAE are frequently studied as models for the human demyelinating...Semple rabies vaccine is derived from brain tissue infected with rabies virus that is subsequently inactivated with phenol. Semple rabies vaccine- induced autoimmune encephalomyelitis (SAE) occurs in 1 in 220 immunized individuals. The immunePublication Metadata only Nodular scleroderma in a patient with chronic hepatitis C virus infection: A coexistent or causal infection?(2015-01-01) Chayada Kokpol; Emily Y. Chu; Suthinee Rutnin; Mahidol University; University of Pennsylvania, Health Systemthe association of HCV infection with systemic autoimmune diseases such as scleroderma....Copyright © Cutis 2015. Nodular scleroderma is a rare form of scleroderma that may occur systemically or locally. The pathogenesis of this variant is unknown. We report the case of a 63-year-old woman with systemic scleroderma and chronic hepatitisItem Metadata only Elucidating the function of STING in systemic lupus erythematosus through the STING Goldenticket mouse mutant(2024-12-01) Vejvisithsakul P.P.; Thumarat C.; Leelahavanichkul A.; Hirankan N.; Pisitkun T.; Paludan S.R.; Pisitkun P.; Vejvisithsakul P.P.; Mahidol Universityin Sting missense mutant mice (Goldenticket or StingGt), which contrasts with previous research using Sting knockout mice. Investigating two-month-old StingGt mice over six months post-PIL induction, we observed a profound reduction in autoimmune markers... hemorrhages was significantly diminished in StingGt mice. These findings demonstrate that different genetic approaches to interfere with STING signaling can lead to contrasting outcomes in SLE pathogenesis, which highlights the need for a nuanced understandingPublication Metadata only Association between sarcoidosis, pulse wave velocity, and other measures of subclinical atherosclerosis: a systematic review and meta-analysis(2018-10-01) Wai Chung Yong; Anawin Sanguankeo; Sikarin Upala; The University of Chicago; Faculty of Medicine, Siriraj Hospital, Mahidol University; Baystate Franklin Medical Center; The Johns Hopkins School of Medicine© 2017, International League of Associations for Rheumatology (ILAR). Chronic inflammation from autoimmune diseases has shown to be a risk factor for atherosclerosis, subsequently leading to cardiovascular disease. Endothelial dysfunction... is the early pathogenesis of atherosclerosis in chronic inflammation, but the risk of atherosclerosis in sarcoidosis is less well defined. This meta-analysis aimed to explore the association of subclinical atherosclerosis and arterial stiffness in sarcoidosisItem Metadata only Activation of circulating TFH17 cells associated with activated naive and double negative 2 B cell expansion, and disease activity in systemic lupus erythematosus patients(2024-12-01) Khunsri T.; Thawornpan P.; Tianpothong P.; Suangtamai T.; Ngamjanyaporn P.; Leepiyasakulchai C.; Wangriatisak K.; Pisitkun P.; Chootong P.; Khunsri T.; Mahidol UniversityBackground: Systemic lupus erythematosus (SLE) is the quintessential autoimmune disease, as it is characterized by hyperactivity of CD4+ T cells and subsequently drives lupus pathology. Follicular helper T (TFH) cells play an important role in B... was significantly associated with disease activity score, aNAV, DN2 B cell expansion, and anti-dsDNA antibody level. Thus, the interactions among cTFH1, cTFH17, and B cells likely contribute to the development of autoantibodies and the pathogenesis in SLE.Item Metadata only Vitamin D and systemic lupus erythematosus(Mahidol University. Mahidol University Library and Knowledge Center, 2024) Chanikarn Patcharapojanart; Kumutnart Chanprapaph; Jutamas Tankunakornshow that hypovitaminosis D may contribute to lupus pathogenesis and higher disease activity. Although no available consensus exists regarding vitamin D status and treatment for immunological purposes in SLE, the recent studies show that vitamin D...Systemic lupus erythematosus (SLE) is an autoimmune disorder which has been linked to multifactorial aspects such as genetic susceptibility infection and environmental factor. Vitamin D deficiency is one of the compelling factors that are currentlyPublication Metadata only Codon72 polymorphism in the p53 tumor suppressor gene in oral lichen planus lesions in a Thai population(2010-01-01) Pattamawadee Yanatatsaneeji; Nakarin Kitkumthorn; Chutintorn Dhammawipark; Jierada Rabalert; Vyomesh Patel; Apiwat Mutirangura; Chulalongkorn University; Mahidol University; National Institute of Dental and Craniofacial ResearchBackground: Oral lichen planus (OLP) is a T-cell mediated autoimmune disease in which autocytotoxic CD8+ T cells (CTLs) trigger apoptosis of oral epithelial cells. Activated CTLs can produce Fas ligand and by binding to Fas lead to apoptosis... association between the pro/pro genotype and OLP, and that the process of apoptosis, in which p53 plays a role, is a factor in OLP pathogenesis.