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Item Metadata only Effect of praziquantel on the structure of liver and small intestine in mice(Mahidol University. Mahidol University Library and Knowledge Center, 1991) Kledkaew Panyong; Prasert Sobhon; Suchart Upatham; Chaitip WanichanonThe histological and ultrastructural changes occurring in the liver and small intestine of mice were examined by light and transmission electron microscopy, following the oral administration of praziquantel at the dosages of 250 mg/kg/day for 5... of lipid droplets, mitochondrial swelling, degeneration and clumping of chromatin and the presence of intranuclear inclusions. In comparison to the liver cells, the intestinal epithelial cells showed only mild degenerative changes consisting of decreasedItem Metadata only The acute stimulatory effect of prolaction on active calcium absorption in rat intestine(Mahidol University. Mahidol University Library and Knowledge Center, 2024) Premtip Thaveeratitham; Nateetip Krishnamra; Liangchai Limlomwongse; Chumpol PholpramoolThe acute effect of prolactin on active calcium absorption was investigated in weaned, young, sexually mature and aged female Wistar rats by using everted gut sac technique. The serosal/mucosal or [S]/[M] ratio of 45Ca concentration was used... as an index of active calcium transport. The data showed that intraperitoneal injection of 0.02 mg prolactin/100 g BW, 5 and 10 minutes before experiment could increase the active calcium transport in the duodenum but not other intestinal segments of sexualPublication Metadata only Infectious drug resistance in Thailand. VI. Effect of a small dose of tetracycline on intestinal Escherichia coli(1973-01-01) V. Meevootisom; W. D. Sawyer; Mahidol UniversityStudies carried out reaffirmed the high prevalence of drug resistant E. coli in the intestinal flora of healthy residents of Thailand and confirmed that the organisms often exhibit infectious drug resistance. The regular administration of small... doses of tetracycline promoted uniform colonization of the gastrointestinal tract by drug resistant E. coli but did not affect the distribution of smooth and rough bacteria. The findings indicated that smooth E. coli dominated the intestinal E. coliPublication Metadata only Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs(2020-04-11) Raditya Iswandana; Bao Tung Pham; Su Suriguga; Theerut Luangmonkong; Louise A. Van Wijk; Yvette J.M. Jansen; Dorenda Oosterhuis; Henricus Antonius Maria Mutsaers; Peter Olinga; Hanoi University; Universitas Indonesia; Aarhus Universitet; Mahidol University; University of Groningenprocess was studied on gene and protein level using procollagen 1a1 (Col1α1), heat shock protein 47 (Hsp47), fibronectin (Fn2), and plasminogen activator inhibitor-1 (Pai-1). The effects of potential antifibrotic drugs mainly inhibiting the transforming... potential preclinical screening tool for antifibrotic drugs. We demonstrated that sunitinib reduced the expression of several fibrosis markers, warranting further evaluation of this compound for the treatment of intestinal fibrosis.Publication Metadata only Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells(2017-06-01) Pawin Pongkorpsakol; Chantapol Yimnual; Varanuj Chatsudthipong; Vatcharin Rukachaisirikul; Chatchai Muanprasat; Mahidol University; Prince of Songkla Universityvia mechanisms involving AMPK activation and NF-κB-suppression. The present study aimed to investigate the effect of FFA on transepithelial Cl− secretion in human intestinal epithelial (T84) cells. FFA inhibited cAMP-dependent Cl− secretion in T84 cell... monolayers with IC50 of ∼8 μM. Other fenamate drugs including tolfenamic acid, meclofenamic acid and mefenamic acid exhibited the same effect albeit with lower potency. FFA also inhibited activities of CFTR, a cAMP-activated apical Cl− channel, and KCNQ1/KCNEItem Metadata only Black ginger extract and its active compound, 5,7-dimethoxyflavone, increase intestinal drug absorption via efflux drug transporter inhibitions(2023-06-01) Boonnop R.; Meetam P.; Siangjong L.; Tuchinda P.; Thongphasuk P.; Soodvilai S.; Soodvilai S.; Mahidol University,7-dimethoxyflavone (DMF) on drug efflux mediated by breast cancer resistance proteins (BCRP) and P-glycoprotein (P-gp) in Caco-2 cells and heterologous cell systems [Madin-Darby canine kidney type II (MDCKII) stably transfected with human BCRP (MDCKII/BCRP) or human... or P-gp. The effect of the extract on 3H-Digoxin and 3H-Estrone sulfate transport was related to a decrease in efflux ratio. Likewise, DMF (5 μM) significantly increased 3H-Digoxin and 3H-Estrone sulfate absorption with a decreased efflux ratio comparedPublication Metadata only Histopathology of small intestine induced by cisplatin in male Wistar rats(2013-11-12) Sarawoot Palipoch; Chuchard Punsawad; Dutsadee Chinnapun; And Prasit Suwannalert; Walailak University; Mahidol UniversityCisplatin, cis-diamminedichloroplatinum (II) is a highly effective drug used to treat several cancers. Unfortunately, it has various clinical side effects affecting many tissues. However, small intestine toxicity induced by cisplatin has been rare... reports to date. This study aims to investigate the pathology of small intestine upon cisplatin treatment at various doses using histological techniques. Male Wistar rats were divided into 5 groups: group 1 was intraperitoneally (IP) injected with normalPublication Metadata only Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets(2011-04-04) Wanwisa Khunawattanakul; Satit Puttipipatkhachorn; Thomas Rades; Thaned Pongjanyakul; Khon Kaen University; Mahidol University; University of Otagoevaluated for use in tablet film coating. Effects of CS-MAS ratio and coating level on water uptake and drug release from the coated tablets were investigated. Surface and film matrix morphology of the coated film and the effect of enzymes in the simulated... gastro-intestinal fluid on drug release were also examined. The results demonstrated that the CS-MAS coated tablets had a rough surface and a layered matrix film, whereas a smooth surface and dense matrix film on the CS coated tablets was found. HoweverPublication Metadata only Inhibition of intestinal chloride secretion by piperine as a cellular basis for the anti-secretory effect of black peppers(2015-10-05) Pawin Pongkorpsakol; Preedajit Wongkrasant; Saowanee Kumpun; Varanuj Chatsudthipong; Chatchai Muanprasat; Mahidol University; Suan Sunandha Rajabhat University; Bangkok; Thailand Ministry of Educationeffect of piperine involves the inhibition of CFTR, CaCC and cAMP-activated basolateral K+ channels. Piperine represents a novel class of drug candidates for the treatment of diarrheal diseases caused by the intestinal hypersecretion of Cleffect of piperine and its underlying mechanism. Piperine inhibited cAMP-mediated Cl- secretion in human intestinal epithelial (T84) cells, similar to black pepper extractPublication Metadata only Characterization and in vitro evaluation of intestinal absorption of liposomes encapsulating zanamivir(2011-07-01) Boontarika Boonyapiwat; Narong Sarisuta; Sarinnate Kunastitchai; Thailand Ministry of Public Health; Mahidol UniversityZanamivir is currently used for the treatment of H1N1 and H5N1 influenza viruses. Due to its highly hydro-philic property, zanamivir has poor oral bioavailability. Liposomal formulations are known to improve oral absorption of hydrophilic drugs.... The present study investigates the effect of liposomes encapsulating zanamivir on the permeation of zanamivir across Caco-2 monolayers. Among the formulations studied, neutral liposomes composed of Phospholipon ® 90 G and cholesterol at molar ratio of 7:3