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    Development of statistic package for Generalize Linear Model
    (Mahidol University. Mahidol University Library and Knowledge Center, 2003) Wanlop Jaidee; Junya Pattaraarchachai
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    PublicationOpen Access
    Quantitative structure-activity relationship study on phthalimide derivatives as HIV-1 reverse transcriptase inhibitors
    (2001) Jiraporn Ungwtayatorn; Chutima Matayatsuk; Pathanakarn Sothipatcharasai
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    PublicationOpen Access
    Impact of microcredit program on rural out-migration for employment: evidence from village revolving fund program in Kanchanaburi province, Thailand
    (2011-07) Sithon Khun; Aphichat Chamratrithirong; อภิชาติ จำรัสฤทธิรงค์; Chai Podhisita; Mahidol University. Institute for Population and Social Research
    . Important findings from multilevel models indicate that amount of money households borrowed from the Village Revolving Fund program is statistically significant in reducing the probability of rural out-migration for employment (-.00010, p<.001) when other...The government of Thailand has introduced the innovative microcredit scheme, the Village Revolving Fund program (VRF) since 2001, aiming to uplift living conditions of the poor. Using data from the 2003 and 2004 rounds of Kanchanaburi Demographic
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    PublicationOpen Access
    Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria
    (2016) Thanaporn Wattanakul; Pramote Teerapong; Plewes, Katherine; Newton, Paul N.; Wirongrong Chierakul; Kamolrat Silamut; Kesinee Chotivanich; Ronnatrai Ruengweerayut; White, Nicholas J.; Dondorp, Arjen M.; Tarning, Joel; Mahidol University. Faculty of Tropical Medicine. Mahidol‑Oxford Tropical Medicine Research Unit.
    pharmacokinetic model was used for dose optimization simulations. Relationships between paracetamol concentrations with temperature and parasite half-life were investigated using linear and non-linear regression analyses. Results: The population pharmacokinetic... injection on day 0 followed by a single dose administered by the alternative route on day 1. Paracetamol plasma concentrations were quantified frequently and modelled simultaneously using nonlinear mixed-effects modelling. The final population
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    PublicationOpen Access
    Origin of aromatase inhibitory activity via proteochemometric modeling
    (2016-04) Saw Simeon; Ola Spjuth; Maris Lapins; Chanin Nantasenamat; Jarl ES Wikberg; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical Informatics
    of novel inhibitor candidates with high selectivity, lower toxicity and increased potency. Designing a novel therapeutic agent against aromatase could be achieved computationally by means of ligand-based and structure-based methods. For over a decade, we... that aromatase variants have on different AIs. In this study, proteochemometrics modeling was applied to analyze the interaction space between AIs and aromatase variants as a function of their substructural and amino acid features. Good predictive performance
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    PublicationOpen Access
    Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers
    (2016) Sofia Birgersson; Pham Van Toi; Nguyen Thanh Truong; Nguyen Thi Dung; Michael Ashton; Tran Tinh Hien; Angela Abelö; Joel Tarning; Mahidol University. Faculty of Tropical Medicine. Mahidol‑Oxford Tropical Medicine Research Unit
    to 12 h after dose in each period. Artemisinin was quantified in plasma using liquid chromatography coupled with tandem mass spectrometry. A nonlinear mixed-effects modelling approach was utilized to evaluate the population pharmacokinetic properties... of the drug and to investigate the clinical impact of different formulations. Results: The plasma concentration–time profiles for artemisinin were adequately described by a transit-absorption model with a one-compartment disposition, in all four sequences
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    PublicationOpen Access
    Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
    (2012-08-22) Tarning, Joel; Kloprogge, Frank; Piola, Patrice; Dhorda, Mehul; Muwanga, Sulaiman; Turyakira, Eleanor; Nitra Nuengchamnong; นิทรา เนื่องจำนงค์; Nosten, François; Day, Nicholas P.J.; White, Nicholas J.; Guerin, Philippe J.; Lindegardh, Niklas; Tarning, Joel; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.
    pharmacokinetic model for artemether and dihydroartemisinin was developed taking into account different disposition, absorption, error and covariate models. A separate modeling approach and a non-compartmental analysis (NCA) were also performed to enable a... comparison with literature values and different modeling strategies. RESULTS: The treatment was well tolerated and there were no cases of recurrent malaria. A flexible absorption model with sequential zero-order and transit-compartment absorption followed
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    PublicationOpen Access
    Obstetric morbidity care in Thailand: do communities matter?
    (2008-01) Sharad Kumar Sharma; Panee Vong-Ek; ภาณี วงษ์เอก; Boonlert Leoprapai; Mahidol University. Institute for Population and Social Research
    context is associated with obstetric morbidity care-seeking behavior among Thai women in the Kanchanaburi Demographic Surveillance System. Multi-level logistic regression models were fitted to examine the association. While percentage of not working
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    PublicationOpen Access
    Understanding the molecular basis of EGFR kinase domain/MIG-6 peptide recognition complex using computational analyses
    (2015-03-27) Ninnutt Moonrin; Napat Songtawee; Siriluk Rattanabunyong; Surasuk Chunsrivirot; Wanwimon Mokmak; Sissades Tongsima; Kiattawee Choowongkomon; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical Informatics
    of MIG-6_s1 were modeled from the published MIG-6 X-ray structure. The binding dynamics were detailed by applying the molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) method to predict the binding free energy. Both van der Waals interactions... and the results from the computational alanine scanning approach. These residues also had higher hydrogen bond occupancies than other residues at the binding interface. The results from the aforementioned calculations reasonably agreed with the previous
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    PublicationOpen Access
    Assessing the role of undetected colonization and isolation precautions in reducing methicillin-resistant Staphylococcus aureus transmission in intensive care units
    (2010-02) Kypraios, Theodore; O'Neill, Philip D.; Huang, Susan S.; Rifas-Shiman, Sheryl L.; Cooper, Ben S; Kypraios, Theodore; Mahidol University. Faculty of Tropical Medicine
    single-bed adult intensive care units (ICUs) over 17 months. Detected MRSA-positive patients were isolated using single rooms and barrier precautions. Data were analyzed using stochastic transmission models and model fitting was performed within a... Bayesian framework using a Markov chain Monte Carlo algorithm, imputing unobserved MRSA carriage events. RESULTS: Models estimated the mean percent of colonized-patient-days attributed to undetected carriers as 14.1% (95% CI (11.7, 16.5)) averaged across