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Item Open Access In vitro activity of biapenem and comparators against multidrug-resistant and carbapenem-resistant Acinetobacter baumannii isolated from tertiary care hospitals in Thailand(2019) Jantana Houngsaitong; Preecha Montakantikul; Taniya Paiboonwong; Mullika T Chomnawang; Piyatip Khuntayaporn; Suvatna Chulavatnatol; จันทนา ห่วงสายทอง; ปรีชา มนทกานติกุล; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Mahidol University. Faculty of Pharmacy. Department of MicrobiologyAcinetobacter baumannii is one of nosocomial pathogen which emerge as multidrugresistance worldwide. Multidrug-resistant A. baumannii (MDRAB) and carbapenem-resistant A. baumannii (CRAB) are highly concerned due to limitation of therapeutic... options. Antibacterial activity of biapenem was explored in order to overcome bacterial resistance. Total of 412 A. baumannii clinical isolates from 13 tertiary care hospitals in Thailand were collected. MIC values of biapenem and comparators; imipenemItem Metadata only Study of a cellular mechanism of phloracetophenone and its analogues on bile secretion in rats(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Lukmanee Tradtrantip; Pawinee PiyachaturawatItem Metadata only Studies on mechanisms of 4-monohydroxyacetophenone on bile acid independent secretion, and human liver organic anion transporting polypeptide 1B1 and 1B3(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Chitrawina Mahagita; Pawinee PiyachaturawatPublication Metadata only Artemisinin and multidrug-resistant Plasmodium falciparum - a threat for malaria control and elimination(2021-10-01) Mehul Dhorda; Chanaki Amaratunga; Arjen M. Dondorp; Faculty of Tropical Medicine, Mahidol University; Nuffield Department of Medicineresistance and approaches to counter multidrug-resistant falciparum malaria. RECENT FINDINGS: An aggressive malaria elimination programme in the GMS has helped prevent the spread of drug resistance to neighbouring countries. However, parasites carrying.... Treatment strategies designed to prevent the emergence and spread of multidrug resistance must be considered, including deployment of triple drug combination therapies and multiple first-line therapies.Publication Metadata only High prevalence of multidrug resistance in bacterial uropathogens from Kathmandu, Nepal(2012-01-20) Pankaj Baral; Sanjiv Neupane; Bishnu Marasini; Kashi Ghimire; Binod Lekhak; Basudha Shrestha; Tribhuvan University; Mahidol University; Kathmandu Model Hospitalof the UTIs caused by multidrug-resistant (MDR) pathogens and the possibility of transfer of MDR traits between them. The present study aimed to determine the prevalence of MDR bacterial isolates from UTI patients, the antibiotic resistance pattern... and the conjugational transfer of multidrug resistance phenotypes in Escherichia coli (E. coli). Results: Two hundred and nineteen bacterial isolates were recovered from 710 urine samples at Kathmandu Model hospital during the study period. All samples and isolates werePublication Metadata only Comparative in vitro activity of sitafloxacin against multidrug-resistant and carbapenem-resistant acinetobacter baumannii clinical isolates in Thailand(2020-01-01) Taniya Paiboonvong; Vipavee Rodjun; Jantana Houngsaitong; Mullika Chomnawang; Preecha Montakantikul; Suvatna Chulavatnatol; Siam University; Mahidol University© 2020 Faculty of Pharmacy. The rapid emergence of multidrug-resistant Acinetobacter baumannii (MDRAB) is recognized as a significant health problem worldwide, including Thailand. Due to a limitation of treatment option, a new antimicrobial agent... and compare that with other antimicrobial agents against A. baumannii clinical isolates, focusing on multidrug-resistant A. baumannii and carbapenem-resistant A. baumannii (MDR-CRAB). All 350 A. baumannii clinical isolates were collected from thirteen tertiaryPublication Metadata only In vitro susceptibility testing of levofloxacin and ofloxacin by microtiter plate alamar blue against multidrug and non multidrug resistant Mycobacterium tuberculosis in Thailand(2001-09-01) Roongnapa Pracharktam; Kanung Angkananukool; Asda Vibhagool; Mahidol UniversityAntituberculous drugs for current therapy of multidrugs resistant tuberculosis (MDR-TB) are limited. The in vitro susceptibility of Mycobacterium tuberculosis (MTB) as well as MDRTB with other antibiotic drugs were determined in order to findPublication Metadata only Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro(2006-12-01) S. Nakornchai; P. Konthiang; Mahidol UniversityAzithromycin, an azalide analog of erythromycin was assayed for its in vitro activity against multidrug-resistant Plasmodium falciparum K1 strain by measuring the3H-hypoxanthine incorporation. Azithromycin caused inhibitory effects on the parasite... might inhibit the ability to treat malaria patients with chloroquine-azithromycin and chloroquine-erythromycin in areas of drug-resistant. The best drug combinations against multidrug-resistant P. falciparum are quinine-azithromycin and quinineItem Metadata only A study of genomic complexity underlying multidrug resistance in Candida auris strains in Thailand(2025-12-01) Opassathian K.; Boonmee N.; Swangkaew S.; Jenjaroenpun P.; Wongsurawat T.; Kruasuwan W.; Ngamskulrungroj P.; Mitrpant C.; Opassathian K.; Mahidol UniversityCandida auris, one of the emerging multidrug-resistant Candida species, was first discovered in 2009 from the ear canal of a patient in Tokyo, Japan. Since then, several studies exhibit the possible threats of C. auris due to its versatile... resistance to frontline antifungal agents. The number of studies focusing on genetic variants associated with multidrug resistance has risen over a decade. In this study, we retrieved eight C. auris strains, originated from clinical isolates in BangkokPublication Metadata only AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant Achromobacter xylosoxidans in a teaching hospital in Thailand(2020-07-01) Pisut Pongchaikul; Pitak Santanirand; Svetlana Antonyuk; Craig Winstanley; Alistair C. Darby; University of Liverpool; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol University© FEMS 2020. This study investigated the genetic basis of multidrug resistance in two strains of Achromobacter xylosoxidans isolated from patients attending a hospital in Thailand in 2012. These isolates were highly resistant to cephalosporins.... This In687 shares 100% identical nucleotide sequence with ones found in Acinetobacter baumannii Aci 16, isolated from the same hospital in 2007. We report the first analysis of multidrug-resistant A. xylosoxidans isolated in Thailand, and the first example