73 results
Search Results
Now showing 1 - 10 of 73
Item Metadata only Development of immunodiagnostic tests for snake venoms of Thailand(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Leera Chinonavanig; Kavi Ratanabanangkoon; Pornchai Matangkasombut; Srisin KhusmithThe rational treatment of snake venom poisoning involves the administration of specific antivenom. Since horse antivenoms produced in Thailand are monovalent and cross-neutralization among them is minimal or absent, the selection of antivenom... for the treatment and thus the correct identification of the culprit snake are of crucial importance. Diagnosis of snakebite based on the clinical manifestations of the victims is difficult because several venoms produce similar signs and symptoms. In order to aidItem Open Access Mechanism of Lotthanong as anti-snake venom(2005) Opa Vajragupta; Maleeruk Utsintong; Wichet Leelamanit; Atchara Kaewnoi; โอภา วัชระคุปต์; วิเชษฐ์ ลีลามานิตย์; อัจฉรา แก้วน้อย; Mahidol Univesity. Faculty of Pharmacy. Department of Pharmaceutical Chemistry; School of Pharmacy (Vietnam), University of Medicine and PharmacyItem Metadata only A study on the pepsin digestion of the horse anti-snake venom(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Sit Thirapakpoomanunt; Kavi Ratanabanangkoon; Pornchai MatangkasombutA study was carried out aiming at optimizing the pepsin digestion reaction of horse antiserum against snake venoms. Rabbit antibodies, specific to horse antivenom IgG/IgG(T), horse F(ab2) and horse Fc, were prepared and purified by using differentItem Metadata only การรักษาผู้ป่วยถูกงูพิษกัด(2525) บุญเยือน ทุมวิภาต; วิโรจน์ นุตพันธ์Item Metadata only Studies on the effects of hyaluronidase inhibitors and antivenom antibody on the local tissue damage caused by Naja kaouthia and Calloselasma rhodostoma venoms(Mahidol University. Mahidol University Library and Knowledge Center, 2002) Senee Yingprasertchai; Kavi Ratanabanangkoon; Chalobon Yoosook; Prasit PalittapongarnpimItem Metadata only Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits(2023-09-01) Ratanabanangkoon K.; Mahidol University, for the culprit snake to be identified, so that the appropriate specific antivenom can be selected. Polyvalent antivenoms (pAVs) are produced via immunization with a number of snake venoms, and the serum can neutralize all the venoms used in its production. Thus..., pAVs can be used to treat several venoms from a country/region, and the identification of the culprit snake is not necessary. There are various parameters and processes involved in the production of pAVs, depending on the requirements and resourcesItem Metadata only Studies on the improvement of immunogenicity of elapid snake postsynaptic neurotoxins(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Patcharee Sunthornandh; Kavi Ratanabanangkoon; Stitaya Sirisinha; Pornchai Matangkasombut; Wanpen Chaicumpasize and abundance of protein components, percent toxin reacted and toxin density. The relative immunogenicities of seven immunogens (I to VII) along with those of crude NNS venom and pure NNS postsynaptic neurotoxin were evaluated in groups of 8 rats... found to be at least as immunogenic as NNS venom. NNS-TT-ECDI gave the highest antibody response (2.7-6.2 fold higher than that induced by NNS venom) while pure NNS postsynapic neurotoxin was among the least immunogenuc. The 3 multispecific immunogensItem Metadata only Development of drugs from therapeutic targets in cobra venom using structure based drug design and virtual screening(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Maleeruk Utsintong; Opa VajraguptaPublication Metadata only Inhibitory effect of tea polyphenols on local tissue damage induced by snake venoms(2010-01-01) P. Pithayanukul; J. Leanpolchareanchai; R. Bavovada; Mahidol University; Chulalongkorn University. These snake venom enzymes are responsible for the early effects of envenomation, such as local tissue damage and infl ammation. The CS extract inhibited phospholipase A2, proteases, hyaluronidase and L-amino acid oxidase in both venoms by in vitro... neutralization and inhibited the hemorrhagic and the dermonecrotic activities of the venoms in vivo. It is suggested that the inhibitory potential of the CS extract against local tissue damage induced by snake venoms may be attributed to complexationItem Metadata only Monoclonal antibodies neutralizing the neurotoxin from the venom of the snake Naja kaouthia(Mahidol University. Mahidol University Library and Knowledge Center, 1988) Chulee Masathien; Billings, Peter B.Monoclonal antibodies were produced against the principal neurotoxin (siamensis toxin 3) purified from venom of the Thai cobra, Naja kaouthia (Naja naja siamensis), as part of a study aimed at enhancing the neutralization capacity of commercial