Browsing by Author "Antoine Jaquet"

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    Diagnosis and clinical outcomes of extrapulmonary tuberculosis in antiretroviral therapy programmes in low- and middle-income countries: a multicohort study
    (2019-09-01) Kathrin Zürcher; Marie Ballif; Sasisopin Kiertiburanakul; Henri Chenal; Marcel Yotebieng; Beatriz Grinsztejn; Denna Michael; Timothy R. Sterling; Kapella M. Ngonyani; Anna M. Mandalakas; Matthias Egger; April C. Pettit; Lukas Fenner; Valdilea Veloso; Paula Luz; Raquel de Boni; Sandra Cardoso Wagner; Ruth Friedman; Ronaldo Moreira; Juan Sierra Madero; Brenda Crabtree Ramirez; Paco Belaunzaran; Yanink Caro Vega; Eduardo Gotuzzo; Fernando Mejia; Gabriela Carriquiry; Catherine C. McGowan; Bryan E. Shepherd; Karu Jayathilake; Anna K. Person; Peter F. Rebeiro; Mark Giganti; Jessica Castilho; Stephany N. Duda; Fernanda Maruri; Hilary Vansell; E. Uy; R. Bantique; A. vihingsanon; S. Gatechompol; P. Phanuphak; C. Phadungphon; S. Kiertiburanakul; A. Phuphuakrat; L. Chumla; N. Sanmeema; K. V. Nguyen; H. V. Bui; D. T.H. Nguyen; D. T. Nguyen; D. D. Cuong; N. V. An; N. T. Luan; A. H. Sohn; J. L. Ross; B. Petersen; D. A. Cooper; M. G. Law; A. Jiamsakul; D. C. Boettiger; John Ssali; Mathew Ssemakadde; Kapella Ngonyani; Jerome Lwali; Mark Urassa; Richard Machemba; Kara Wools-Kaloustian; Constantin Yiannoutsos; Rachel Vreeman; Beverly Musick; Batya Elul; Rami Kantor; Jeffrey Martin; Megan Wenger; Craig Cohen; Jayne Kulzer; Djimon Marcel Zannou; Angèle Azon-Kouanou; Hamar Alassane Traore; Daouda Minta; Amadou Abathina Toure; Moussa Seydi; Coumba Cissé Bassabi; François Dabis; Emmanuel Bissagnene; Elise Arrivé; Patrick Coffie; Didier Ekouevi; Antoine Jaquet; Valériane Leroy; Charlotte Lewden; Annie J. Sasco; Dieudonné Amani; Jean Claude Azani; Eric Balestre; Serge Bessekon; Franck Bohossou; Camille Gilbert; Sophie Karcher; Institut fur Sozial- und Praventivmedizin; National Institute for Medical Research Tanga; Vanderbilt University Medical Center; Fundacao Oswaldo Cruz; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Vanderbilt University; Ohio State University; Baylor College of Medicine; University of Cape Town; Tumbi Special Hospital; Centre Intégré de Recherches Biocliniques d'Abidjan (CIRBA)
    © 2019 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. Introduction: Extrapulmonary tuberculosis (EPTB) is difficult to confirm bacteriologically and requires specific diagnostic capacities. Diagnosis can be especially challenging in under-resourced settings. We studied diagnostic modalities and clinical outcomes of EPTB compared to pulmonary tuberculosis (PTB) among HIV-positive adults in antiretroviral therapy (ART) programmes in low- and middle-income countries (LMIC). Methods: We collected data from HIV-positive TB patients (≥16 years) in 22 ART programmes participating in the International Epidemiology Databases to Evaluate AIDS (IeDEA) consortium in sub-Saharan Africa, Asia-Pacific, and Caribbean, Central and South America regions between 2012 and 2014. We categorized TB as PTB or EPTB (EPTB included mixed PTB/EPTB). We used multivariable logistic regression to assess associations with clinical outcomes. Results and Discussion: We analysed 2695 HIV-positive TB patients. Median age was 36 years (interquartile range (IQR) 30 to 43), 1102 were female (41%), and the median CD4 count at TB treatment start was 114 cells/μL (IQR 40 to 248). Overall, 1930 had PTB (72%), and 765 EPTB (28%). Among EPTB patients, the most frequently involved sites were the lymph nodes (24%), pleura (15%), abdomen (11%) and meninges (6%). The majority of PTB (1123 of 1930, 58%) and EPTB (582 of 765, 76%) patients were diagnosed based on clinical criteria. Bacteriological confirmation (using positive smear microscopy, culture, Xpert MTB/RIF, or other nucleic acid amplification tests result) was obtained in 897 of 1557 PTB (52%) and 183 of 438 EPTB (42%) patients. EPTB was not associated with higher mortality compared to PTB (adjusted odd ratio (aOR) 1.0, 95% CI 0.8 to 1.3), but TB meningitis was (aOR 1.9, 95% CI 1.0 to 3.1). Bacteriological confirmation was associated with reduced mortality among PTB patients (aOR 0.7, 95% CI 0.6 to 0.8) and EPTB patients (aOR 0.3 95% CI 0.1 to 0.8) compared to TB patients with a negative test result. Conclusions: Diagnosis of EPTB and PTB at ART programmes in LMIC was mainly based on clinical criteria. Greater availability and usage of TB diagnostic tests would improve the diagnosis and clinical outcomes of both EPTB and PTB.
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    A survey of paediatric HIV programmatic and clinical management practices in Asia and sub-Saharan Africa - The International epidemiologic Databases to Evaluate AIDS (IeDEA)
    (2013-01-15) V. Saphonn; U. Vibol; N. Kumarasamy; N. Kurniati; S. M. Fong; N. K. Nik Yusoff; K. A. Razali; R. Nallusamy; V. Sirisanthana; R. Hansudewechakul; P. Lumbiganon; J. Ananworanich; K. Chokephaibulkit; H. K. Truong; C. V. Do; B. V. Huy; A. H. Sohn; M. G. Law; Cleophas Chimbetete; Brian Eley; Daniele Garone; Janet Giddy; Harry Moultrie; Sam Phiri; Hans Prozesky; Karl Technau; Paula Vaz; Robin Wood; François Dabis; Emmanuel Bissagnene; Marcel D. Zannou; Joseph Drabo; Serge Paul Eholie; Kevin Peterson; Lorna Renner; Moussa Maiga; Man Charurat; Haby Signaté Sy; Didier K. Ekouévi; Antoine Jaquet; Valériane Leroy; Charlotte Lewden; Annette H. Sohn; National Centre for HIV/AIDS Dermatology and STDs; National Pediatric Hospital; Gaitonde Centre for AIDS Research and Education; General Hospital; Hospital Likas; Hospital Raja Perempuan Zainab II; Kuala Lumpur Hospital; Penang Hospital; Chiang Mai University; Chiangrai Prachanukroh Hospital; Khon Kaen University; The HIV Netherlands Australia Thailand Research Collaboration; Mahidol University; Children's Hospital 1; Children's Hospital 2; National Hospital of Pediatrics Hanoi; amfAR - The Foundation for AIDS Research; University of New South Wales (UNSW) Australia; Newlands Clinic; Red Cross War Memorial Children's Hospital; Khayelitsha ART Programme and Médecins Sans Frontières; McCord Hospital; University of Witwatersrand; Lighthouse Clinic; Tygerberg Hospital; Paediatric Day Hospital; Desmond Tutu HIV Centre (Gugulethu and Masiphumelele clinics); Inserm; Centre Hospitalier Universitaire de Treichville; Foundation for AIDS Research
    Introduction: There are limited data on paediatric HIV care and treatment programmes in low-resource settings. Methods: A standardized survey was completed by International epidemiologic Databases to Evaluate AIDS paediatric cohort sites in the regions of Asia-Pacific (AP), Central Africa (CA), East Africa (EA), Southern Africa (SA) and West Africa (WA) to understand operational resource availability and paediatric management practices. Data were collected through January 2010 using a secure, web-based software program (REDCap). Results: A total of 64,552 children were under care at 63 clinics (AP, N =10; CA, N =4; EA, N =29; SA, N =10; WA, N =10). Most were in urban settings (N =41, 65%) and received funding from governments (N =51, 81%), PEPFAR (N =34, 54%), and/or the Global Fund (N =15, 24%). The majority were combined adult-paediatric clinics (N =36, 57%). Prevention of mother-to-child transmission was integrated at 35 (56%) sites; 89% (N =56) had access to DNA PCR for infant diagnosis. African (N =40/53) but not Asian sites recommended exclusive breastfeeding up until 4-6 months. Regular laboratory monitoring included CD4 (N =60, 95%), and viral load (N =24, 38%). Although 42 (67%) sites had the ability to conduct acid-fast bacilli (AFB) smears, 23 (37%) sites could conduct AFB cultures and 18 (29%) sites could conduct tuberculosis drug susceptibility testing. Loss to follow-up was defined as >3 months of lost contact for 25 (40%) sites, >6 months for 27 sites (43%) and >12 months for 6 sites (10%). Telephone calls (N =52, 83%) and outreach worker home visits to trace children lost to follow-up (N =45, 71%) were common. Conclusions: In general, there was a high level of patient and laboratory monitoring within this multiregional paediatric cohort consortium that will facilitate detailed observational research studies. Practices will continue to be monitored as the WHO/UNAIDS Treatment 2.0 framework is implemented. © 2013 IeDEA Pediatric Working Group; licensee International AIDS Society.