Publication:
A survey of paediatric HIV programmatic and clinical management practices in Asia and sub-Saharan Africa - The International epidemiologic Databases to Evaluate AIDS (IeDEA)

Issued Date

2013-01-15

Resource Type

Article

ISSN

17582652

DOI

10.7448/IAS.16.1.17998

Other identifier(s)

2-s2.0-84879590503

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of the International AIDS Society. Vol.16, (2013)

Suggested Citation

V. Saphonn, U. Vibol, N. Kumarasamy, N. Kurniati, S. M. Fong, N. K. Nik Yusoff, K. A. Razali, R. Nallusamy, V. Sirisanthana, R. Hansudewechakul, P. Lumbiganon, J. Ananworanich, K. Chokephaibulkit, H. K. Truong, C. V. Do, B. V. Huy, A. H. Sohn, M. G. Law, Cleophas Chimbetete, Brian Eley, Daniele Garone, Janet Giddy, Harry Moultrie, Sam Phiri, Hans Prozesky, Karl Technau, Paula Vaz, Robin Wood, François Dabis, Emmanuel Bissagnene, Marcel D. Zannou, Joseph Drabo, Serge Paul Eholie, Kevin Peterson, Lorna Renner, Moussa Maiga, Man Charurat, Haby Signaté Sy, Didier K. Ekouévi, Antoine Jaquet, Valériane Leroy, Charlotte Lewden, Annette H. Sohn A survey of paediatric HIV programmatic and clinical management practices in Asia and sub-Saharan Africa - The International epidemiologic Databases to Evaluate AIDS (IeDEA). Journal of the International AIDS Society. Vol.16, (2013). doi:10.7448/IAS.16.1.17998 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32573

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Title

A survey of paediatric HIV programmatic and clinical management practices in Asia and sub-Saharan Africa - The International epidemiologic Databases to Evaluate AIDS (IeDEA)

Author(s)

V. Saphonn
 U. Vibol
 N. Kumarasamy
 N. Kurniati
 S. M. Fong
 N. K. Nik Yusoff
 K. A. Razali
 R. Nallusamy
 V. Sirisanthana
 R. Hansudewechakul
 P. Lumbiganon
 J. Ananworanich
 K. Chokephaibulkit
 H. K. Truong
 C. V. Do
 B. V. Huy
 A. H. Sohn
 M. G. Law
 Cleophas Chimbetete
 Brian Eley
 Daniele Garone
 Janet Giddy
 Harry Moultrie
 Sam Phiri
 Hans Prozesky
 Karl Technau
 Paula Vaz
 Robin Wood
 François Dabis
 Emmanuel Bissagnene
 Marcel D. Zannou
 Joseph Drabo
 Serge Paul Eholie
 Kevin Peterson
 Lorna Renner
 Moussa Maiga
 Man Charurat
 Haby Signaté Sy
 Didier K. Ekouévi
 Antoine Jaquet
 Valériane Leroy
 Charlotte Lewden
 Annette H. Sohn

Other Contributor(s)

National Centre for HIV/AIDS Dermatology and STDs
 National Pediatric Hospital
 Gaitonde Centre for AIDS Research and Education
 General Hospital
 Hospital Likas
 Hospital Raja Perempuan Zainab II
 Kuala Lumpur Hospital
 Penang Hospital
 Chiang Mai University
 Chiangrai Prachanukroh Hospital
 Khon Kaen University
 The HIV Netherlands Australia Thailand Research Collaboration
 Mahidol University
 Children's Hospital 1
 Children's Hospital 2
 National Hospital of Pediatrics Hanoi
 amfAR - The Foundation for AIDS Research
 University of New South Wales (UNSW) Australia
 Newlands Clinic
 Red Cross War Memorial Children's Hospital
 Khayelitsha ART Programme and Médecins Sans Frontières
 McCord Hospital
 University of Witwatersrand
 Lighthouse Clinic
 Tygerberg Hospital
 Paediatric Day Hospital
 Desmond Tutu HIV Centre (Gugulethu and Masiphumelele clinics)
 Inserm
 Centre Hospitalier Universitaire de Treichville
 Foundation for AIDS Research

Abstract

Introduction: There are limited data on paediatric HIV care and treatment programmes in low-resource settings. Methods: A standardized survey was completed by International epidemiologic Databases to Evaluate AIDS paediatric cohort sites in the regions of Asia-Pacific (AP), Central Africa (CA), East Africa (EA), Southern Africa (SA) and West Africa (WA) to understand operational resource availability and paediatric management practices. Data were collected through January 2010 using a secure, web-based software program (REDCap). Results: A total of 64,552 children were under care at 63 clinics (AP, N =10; CA, N =4; EA, N =29; SA, N =10; WA, N =10). Most were in urban settings (N =41, 65%) and received funding from governments (N =51, 81%), PEPFAR (N =34, 54%), and/or the Global Fund (N =15, 24%). The majority were combined adult-paediatric clinics (N =36, 57%). Prevention of mother-to-child transmission was integrated at 35 (56%) sites; 89% (N =56) had access to DNA PCR for infant diagnosis. African (N =40/53) but not Asian sites recommended exclusive breastfeeding up until 4-6 months. Regular laboratory monitoring included CD4 (N =60, 95%), and viral load (N =24, 38%). Although 42 (67%) sites had the ability to conduct acid-fast bacilli (AFB) smears, 23 (37%) sites could conduct AFB cultures and 18 (29%) sites could conduct tuberculosis drug susceptibility testing. Loss to follow-up was defined as >3 months of lost contact for 25 (40%) sites, >6 months for 27 sites (43%) and >12 months for 6 sites (10%). Telephone calls (N =52, 83%) and outreach worker home visits to trace children lost to follow-up (N =45, 71%) were common. Conclusions: In general, there was a high level of patient and laboratory monitoring within this multiregional paediatric cohort consortium that will facilitate detailed observational research studies. Practices will continue to be monitored as the WHO/UNAIDS Treatment 2.0 framework is implemented. © 2013 IeDEA Pediatric Working Group; licensee International AIDS Society.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/32573

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Scopus 2011-2015