Browsing by Author "Centre Hospitalier Universitaire de Fort de France"

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    Asian and African/Caribbean AQP4-NMOSD patient outcomes according to self-identified race and place of residence
    (2021-08-01) Ricardo Soares-dos-Reis; Jessica Li Tsz-Ching; Su Hyun Kim; Anu Jacob; Daniel Whittam; Emeline Berthelot; Friedemann Paul; Ichiro Nakashima; Janis Siew Noi Tye; Jerôme De Seze; Jiraporn Jitprapaikulsan; Kevin Tan; Li Yang; Liene Elsone; Maria Isabel Leite; Maureen A. Mealy; Michael Levy; Moli Fan; Nadja Siebert; Nasrin Asgari; Philippe Cabre; Sasitorn Siritho; Sean J. Pittock; Stephen Cheng Wing-Ho; Thomas Senger; Tianrong Yeo; Yoshiki Takai; Lekha Pandit; Ho Jin Kim; Jacqueline Palace; Siriraj Hospital; Graduate School of Medicine; Oxford University Hospitals NHS Foundation Trust; The Walton Centre NHS Foundation Trust; Cleveland Clinic Abu Dhabi; Nitte (Deemed to be University); Centre Hospitalier Universitaire de Fort de France; National Cancer Center, Gyeonggi; Massachusetts General Hospital; Charité – Universitätsmedizin Berlin; National Neuroscience Institute of Singapore; Max Delbruck Center for Molecular Medicine; Bumrungrad International Hospital; Tohoku Medical and Pharmaceutical University; Syddansk Universitet; Faculdade de Medicina da Universidade do Porto (FMUP); Queen Elizabeth Hospital Hong Kong; Slagelse Sygehus; Tianjin Medical University; Les Hôpitaux Universitaires de Strasbourg; John Radcliffe Hospital; Mayo Clinic; University of Oxford Medical Sciences Division; Johns Hopkins School of Medicine; Pamela Youde Nethersole Eastern Hospital; Centro Hospitalar Universitário de São João; NeuroCure Clinical Research Center
    Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy characterized by aquaporin-4 antibodies, whose prognosis is influenced by onset age, race, environmental exposures and immunosuppression. Distinguishing the contribution of environment from genetics is challenging. We aimed to compare neuromyelitis optica spectrum disorder (NMOSD) patient outcomes according to self-identified racial group and place of residence. Methods: This retrospective analysis of prospectively collected data included non-white anti-aquaporin-4 antibody positive NMOSD patients under follow-up from 15 centers [United Kingdom, France, Germany, Denmark, Martinique, United States of America, Japan, South Korea, Singapore, Thailand, China (including Hong Kong) and India]. Racial groups were designated: African/Caribbean; South Asian; East Asian (including Southeast Asia). Patients from these racial groups residing outside Africa/Caribbean or Asia were compared with those living in the Caribbean or the Asian areas. Kaplan-Meier survival curves and Cox models were generated using time to sustained Expanded Disability Status Scale≥6.0 or death; time to sustained Kurtzke Visual Function Score≥3.0 or a composite endpoint of all three. Results: Among 821 patients, African/Caribbean patients (n = 206) had the shortest time to immunosuppression and higher visual disability at onset. South Asian patients (n = 65) were younger, had lower visual disability at onset and higher mortality rate. East Asians (n = 550) had the lowest relapse rate and lowest accrued motor disability. Survival analysis of African/Caribbean outside Africa/Caribbean vs those in the Caribbean showed a significant difference in the composite endpoint (p = 0.024,log-rank test), not apparently related to treatment differences. No significant differences between native and those residing outside Asia were found for other racial groups. Conclusion: This NMOSD study reports the effects of place of residence on the outcomes in different races. Place of residence may not be a significant driver of disability among Asian patients, while it may influence African/Caribbean patient outcomes. Validating these findings could help distinguish between genetic causes and potentially modifiable environmental factors.
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    Use of advanced magnetic resonance imaging techniques in neuromyelitis optica spectrum disorder
    (2015-07-01) Stephane Kremer; Felix Renard; Sophie Achard; Marco A. Lana-Peixoto; Jacqueline Palace; Nasrin Asgari; Eric C. Klawiter; Silvia N. Tenembaum; Brenda Banwell; Benjamin M. Greenberg; Jeffrey L. Bennett; Michael Levy; Pablo Villoslada; Albert Saiz; Kazuo Fujihara; Koon Ho Chan; Sven Schippling; Friedemann Paul; Ho Jin Kim; Jerome De Seze; Jens T. Wuerfel; Philippe Cabre; Romain Marignier; Thomas Tedder; Danielle Van Pelt; Simon Broadley; Tanuja Chitnis; Dean Wingerchuk; Lekha Pandit; Maria Isabel Leite; Metha Apiwattanakul; Ingo Kleiter; Naraporn Prayoonwiwat; May Han; Kerstin Hellwig; Katja Van Herle; Gareth John; D. Craig Hooper; Ichiro Nakashima; Douglas Sato; Michael R. Yeaman; Emmanuelle Waubant; Scott Zamvil; Olaf Stüve; Orhan Aktas; Terry J. Smith; Anu Jacob; Kevin O'Connor; Universitat Gottingen; University of Oxford; Massachusetts General Hospital; UT Southwestern Medical School; Tohoku University School of Medicine; Centre Hospitalier Universitaire de Fort de France; CHU de Lyon; Duke University School of Medicine; Erasmus University Medical Center; Griffith University; Mayo Clinic Scottsdale-Phoenix, Arizona; Nitte University; Prasat Neurological Institute; Ruhr-Universitat Bochum; Mahidol University; Stanford University School of Medicine; St. Josef-Hospital im Katholischen Klinikum Bochum; The GJCF; The Mount Sinai Hospital; Thomas Jefferson University; University of California, Los Angeles; University of California, San Francisco; Heinrich Heine Universitat; University of Michigan, Ann Arbor; Walton Center; Yale University School of Medicine; Universite de Strasbourg; CHU Strasbourg; CNRS Centre National de la Recherche Scientifique; Universidade Federal de Minas Gerais; Syddansk Universitet; Vejle Sygehus; National Pediatric Hospital Dr. Juan P. Garrahan; University of Pennsylvania; The Children's Hospital of Philadelphia; University of Colorado Health Sciences Center; Johns Hopkins University; Hospital Clinic Barcelona; The University of Hong Kong; UniversitatsSpital Zurich; University Hospital Zurich Neurologische Klinik; Technical High School; University of Zurich; Charité – Universitätsmedizin Berlin; Research Institute; National Cancer Center, Gyeonggi; Inserm
    Copyright 2015 American Medical Association. All rights reserved. Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.