Publication:
Asian and African/Caribbean AQP4-NMOSD patient outcomes according to self-identified race and place of residence

Issued Date

2021-08-01

Resource Type

Article

ISSN

22110356
22110348

DOI

10.1016/j.msard.2021.103080

Other identifier(s)

2-s2.0-85108359399

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Multiple Sclerosis and Related Disorders. Vol.53, (2021)

Suggested Citation

Ricardo Soares-dos-Reis, Jessica Li Tsz-Ching, Su Hyun Kim, Anu Jacob, Daniel Whittam, Emeline Berthelot, Friedemann Paul, Ichiro Nakashima, Janis Siew Noi Tye, Jerôme De Seze, Jiraporn Jitprapaikulsan, Kevin Tan, Li Yang, Liene Elsone, Maria Isabel Leite, Maureen A. Mealy, Michael Levy, Moli Fan, Nadja Siebert, Nasrin Asgari, Philippe Cabre, Sasitorn Siritho, Sean J. Pittock, Stephen Cheng Wing-Ho, Thomas Senger, Tianrong Yeo, Yoshiki Takai, Lekha Pandit, Ho Jin Kim, Jacqueline Palace Asian and African/Caribbean AQP4-NMOSD patient outcomes according to self-identified race and place of residence. Multiple Sclerosis and Related Disorders. Vol.53, (2021). doi:10.1016/j.msard.2021.103080 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78008

Research Projects

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Title

Asian and African/Caribbean AQP4-NMOSD patient outcomes according to self-identified race and place of residence

Author(s)

Ricardo Soares-dos-Reis
 Jessica Li Tsz-Ching
 Su Hyun Kim
 Anu Jacob
 Daniel Whittam
 Emeline Berthelot
 Friedemann Paul
 Ichiro Nakashima
 Janis Siew Noi Tye
 Jerôme De Seze
 Jiraporn Jitprapaikulsan
 Kevin Tan
 Li Yang
 Liene Elsone
 Maria Isabel Leite
 Maureen A. Mealy
 Michael Levy
 Moli Fan
 Nadja Siebert
 Nasrin Asgari
 Philippe Cabre
 Sasitorn Siritho
 Sean J. Pittock
 Stephen Cheng Wing-Ho
 Thomas Senger
 Tianrong Yeo
 Yoshiki Takai
 Lekha Pandit
 Ho Jin Kim
 Jacqueline Palace

Other Contributor(s)

Siriraj Hospital
 Graduate School of Medicine
 Oxford University Hospitals NHS Foundation Trust
 The Walton Centre NHS Foundation Trust
 Cleveland Clinic Abu Dhabi
 Nitte (Deemed to be University)
 Centre Hospitalier Universitaire de Fort de France
 National Cancer Center, Gyeonggi
 Massachusetts General Hospital
 Charité – Universitätsmedizin Berlin
 National Neuroscience Institute of Singapore
 Max Delbruck Center for Molecular Medicine
 Bumrungrad International Hospital
 Tohoku Medical and Pharmaceutical University
 Syddansk Universitet
 Faculdade de Medicina da Universidade do Porto (FMUP)
 Queen Elizabeth Hospital Hong Kong
 Slagelse Sygehus
 Tianjin Medical University
 Les Hôpitaux Universitaires de Strasbourg
 John Radcliffe Hospital
 Mayo Clinic
 University of Oxford Medical Sciences Division
 Johns Hopkins School of Medicine
 Pamela Youde Nethersole Eastern Hospital
 Centro Hospitalar Universitário de São João
 NeuroCure Clinical Research Center

Abstract

Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy characterized by aquaporin-4 antibodies, whose prognosis is influenced by onset age, race, environmental exposures and immunosuppression. Distinguishing the contribution of environment from genetics is challenging. We aimed to compare neuromyelitis optica spectrum disorder (NMOSD) patient outcomes according to self-identified racial group and place of residence. Methods: This retrospective analysis of prospectively collected data included non-white anti-aquaporin-4 antibody positive NMOSD patients under follow-up from 15 centers [United Kingdom, France, Germany, Denmark, Martinique, United States of America, Japan, South Korea, Singapore, Thailand, China (including Hong Kong) and India]. Racial groups were designated: African/Caribbean; South Asian; East Asian (including Southeast Asia). Patients from these racial groups residing outside Africa/Caribbean or Asia were compared with those living in the Caribbean or the Asian areas. Kaplan-Meier survival curves and Cox models were generated using time to sustained Expanded Disability Status Scale≥6.0 or death; time to sustained Kurtzke Visual Function Score≥3.0 or a composite endpoint of all three. Results: Among 821 patients, African/Caribbean patients (n = 206) had the shortest time to immunosuppression and higher visual disability at onset. South Asian patients (n = 65) were younger, had lower visual disability at onset and higher mortality rate. East Asians (n = 550) had the lowest relapse rate and lowest accrued motor disability. Survival analysis of African/Caribbean outside Africa/Caribbean vs those in the Caribbean showed a significant difference in the composite endpoint (p = 0.024,log-rank test), not apparently related to treatment differences. No significant differences between native and those residing outside Asia were found for other racial groups. Conclusion: This NMOSD study reports the effects of place of residence on the outcomes in different races. Place of residence may not be a significant driver of disability among Asian patients, while it may influence African/Caribbean patient outcomes. Validating these findings could help distinguish between genetic causes and potentially modifiable environmental factors.

Keyword(s)

Medicine
 Neuroscience

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/78008

Collections

Scopus 2021