Browsing by Author "Christine Fernandez"

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    Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria
    (2008-10-01) Sue Jean Lee; Rose McGready; Christine Fernandez; Kasia Stepniewska; Moo Koo Paw; Samuel Jacher Viladpai-Nguen; Kyaw Lay Thwai; Leopoldo Villegas; Pratap Singhasivanon; Brian M. Greenwood; Nicholas J. White; François Nosten; Shoklo Malaria Research Unit; Mahidol University; Hopital Pitie Salpetriere; Universite Paris-Sud XI; Instituto de Altos Estudios en Salud Pública; London School of Hygiene & Tropical Medicine; Churchill Hospital
    Purpose: We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria. Methods: Twelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base/kg over 3 days on the northwestern border of Thailand. Blood concentrations of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence detection. Twenty-five women completed the pharmacokinetic study. Results: Although increasing gestational age was associated with reduced chloroquine AUC0→∞, there was no significant difference overall in the pharmacokinetics of chloroquine between pregnant and nonpregnant women. Fever was associated with lower chloroquine AUC0→∞values. Desethylchloroquine area under the curve (AUC) values were not significantly affected by pregnancy. Conclusions: Pregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women with P. vivax malaria. © 2008 The Author(s).