Publication: Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria
Issued Date
2008-10-01
Resource Type
ISSN
00316970
Other identifier(s)
2-s2.0-53249137892
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Clinical Pharmacology. Vol.64, No.10 (2008), 987-992
Suggested Citation
Sue Jean Lee, Rose McGready, Christine Fernandez, Kasia Stepniewska, Moo Koo Paw, Samuel Jacher Viladpai-Nguen, Kyaw Lay Thwai, Leopoldo Villegas, Pratap Singhasivanon, Brian M. Greenwood, Nicholas J. White, François Nosten Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria. European Journal of Clinical Pharmacology. Vol.64, No.10 (2008), 987-992. doi:10.1007/s00228-008-0500-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19532
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Title
Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria
Abstract
Purpose: We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria. Methods: Twelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base/kg over 3 days on the northwestern border of Thailand. Blood concentrations of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence detection. Twenty-five women completed the pharmacokinetic study. Results: Although increasing gestational age was associated with reduced chloroquine AUC0→∞, there was no significant difference overall in the pharmacokinetics of chloroquine between pregnant and nonpregnant women. Fever was associated with lower chloroquine AUC0→∞values. Desethylchloroquine area under the curve (AUC) values were not significantly affected by pregnancy. Conclusions: Pregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women with P. vivax malaria. © 2008 The Author(s).