Scopus 2006-2010
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Publication Metadata only Flow field-flow fractionation: A versatile approach for size characterization of α-tocopherol-induced enlargement of gold nanoparticles(2010-04-01) Wimut Sermsri; Purim Jarujamrus; Juwadee Shiowatana; Atitaya Siripinyanond; Mahidol UniversityFlow field-flow fractionation (FlFFF) was used for size characterization of gold nanoparticles. The measured particle sizes obtained from FlFFF for the commercial 10 nm gold nanoparticle standard and the gold nanoparticles synthesized in the laboratory were in good agreement with those measured by transmission electron microscopy (TEM). Further, the capability of α-tocopherol to induce enlargement of gold nanoparticles by catalysis of the reduction of AuCl4-by citrate was observed by monitoring the changes in particle size of gold nanoparticles using FlFFF. The effects of α-tocopherol and incubation time on enlargement of the gold nanoparticles were examined. Higher concentrations of α-tocopherol resulted in larger nanoparticles. At fixed α-tocopherol concentration, larger nanoparticles were formed at longer incubation times. © 2010 Springer-Verlag.Publication Metadata only Anatomy of L4 to S3 nerve roots.(2010-12-01) Saranatra Waikakul; Supichya Chandraphak; Pichet Sangthongsil; Mahidol UniversityTo study the course of L4 to S3 nerve roots and their distance with the ala of the sacrum and the sacroiliac joint. The embalmed left half pelvis of 25 male and 27 female cadavers aged 30 to 91 (mean, 68) years were studied. The ventral rami of the L4, L5, S1, S2, and S3 nerve roots were dissected along their courses from the corresponding intervertebral foramina to the lesser pelvis. The distances between each nerve root and the most anterior and inferior parts of the sacroiliac joint were measured in both coronal and sagittal planes. There were 3 locations of fusion of L4 and L5 nerve roots: above, on, or below the level of the most anterior part of the sacroiliac joint. Fusion of S1 and S2 nerve roots at the most inferior part of the sacroiliac joint was encountered in 10% of pelvises. Most S1 and S2 nerve roots lay medial to the sacroiliac joint and closed to the anterior cortex of the ala of the sacrum. Sacral nerve roots may fuse at different levels. Most L4 to S3 nerve roots lie close to the anterior surface of the sacroiliac joint and the ala of the sacrum. To prevent nerve root injury, dissection with a sharp instrument should be avoided at such area and 5 to 7 mm medial to the sacroiliac joint.Publication Metadata only Relationship between α-MSH, soluble leptin receptor, MC4R polymorphism and BMI in Thai children and adolescents(2010-12-01) Rungsunn Tungtrongchitr; Benjaluck Phonrat; Uruwan Yamborisut; Supaluk Popruk; Anchalee Tungtrongchitr; Mahidol UniversityIn order to evaluate the mechanism of disturbance of melanocortin signaling in different groups of Thai children and adolescents classified according to body mass index (BMI) percentile for age by The Centers for Disease Control and Prevention (CDC) growth charts, and α-melanocortin stimulating hormone (α-MSH), soluble leptin receptor and melanocortin -4 receptor (MC4R) polymorphism were studied. 149 male and 127 female children and adolescent Thai subjects with age range between 5-19 years were selected. Statistically significant difference of serum leptin receptor concentration between under weight (< 5th percentile), possible at risk for underweight (between 5th and 15th percentile), probably healthy (between 15th and 85th percentile); at risk for overweight (between the 85th and 95th percentile) and overweight (over the 95th percentile) were found. The levels of α-MSH were not significantly different when comparing the groups. Heterozygous of MC4R polymorphism (Val103Ile) were found in underweight, possible at risk for underweight and probably healthy group which might have been the cause of lower BMI for age even they have had normal serum α-MSH concentration. Using the logistic regression analysis, the group of risk for being overweight and overweight was statistically significant with α-MSH. This study supported a positive correlation between α-MSH and BMI with ages of Thai children and adolescents group. © 2010/2011 - IOS Press and the authors. All rights reserved.Publication Metadata only Malarial retinopathy and fluorescein angiography findings in a Malawian child with cerebral malaria(2010-06-01) Simon J. Glover; Richard J. Maude; Terrie E. Taylor; Malcolm E. Molyneux; Nicholas AV Beare; University of Malawi College of Medicine; Mahidol University; Nuffield Department of Clinical Medicine; Michigan State University; Malawi-Liverpool-Wellcome Trust Clinical Research Programme; Liverpool School of Tropical Medicine; Royal Liverpool and Broadgreen University Hospitals NHS TrustPublication Metadata only Optimizing the culture of plasmodium falciparum in hollow fiber bioreactors(2010-07-01) P. Preechapornkul; K. Chotivanich; M. Imwong; A. M. Dondorp; S. J. Lee; N. P J Day; N. J. White; S. Pukrittayakamee; Mahidol University; Churchill HospitalThe hollow fiber bioreactor (HFBR) is a cell culturing system allowing continuous perfusion of medium. It was designed to grow microorganisms in a dynamically altering medium mimicking change in the in vivo intravascular and extravascular compartments. The cell compartment (extra capillary space) and medium compartment (intra capillary space) are connected through pores of semipermeable fiber membranes. These membranes allow exchange of gas and nutrients. We have adapted this system for the ex vivo culture of Plasmodium falciparum at high parasite densities. A Thai P. falciparum isolate (TM036) cultured in RPMI, supplemented with 0.5% Albumax II, could be maintained continuously in the system by daily changes of a small volumes of medium. Under optimized conditions the HFBR cultures attained 8% parasitemia in 40% hematocrit, thereby providing a total parasite biomass of 6.0x109 parasitized erythrocytes. The main problem encountered was clogging of micropores in the hollow fiber system by cellular debris over time. Although 'reverse flushing' partly prevented this, a larger pore size might be needed to overcome this problem. The system opens new possibilities for the study of in vitro drug sensitivity under conditions mimicking in vivo pharmacokinetics, and the selection of anti-malarial drug resistance and associated parasite biological and genomic changes.Publication Metadata only Waking the sleeping beauty(2010-11-01) François Nosten; Mahidol University; Churchill HospitalPublication Metadata only Gene delivery efficacy of polyethyleneimine-introduced chitosan shell/poly(methyl methacrylate) core nanoparticles for rat mesenchymal stem cells(2010-01-01) Nuttaporn Pimpha; Panya Sunintaboon; Supharat Inphonlek; Yasuhiko Tabata; Thailand National Nanotechnology Center; Mahidol University; Kyoto UniversityThis work investigated polyethyleneimine (PEI)-introduced chitosan (CS) (CS/PEI) nanoparticles as non-viral carrier of plasmid DNA for rat mesenchymal stem cells (MSCs). The CS/PEI nanoparticles were prepared by the emulsifier-free emulsion polymerization of methyl methacrylate monomer induced by a small amount of t-butyl hydroperxide in the presence of different concentrations of PEI mixed with CS. The resulting nanoparticles were characterized by their surface properties and buffering capacity. In vitro gene transfection was also evaluated. The introduction of PEI affected the surface charge, dispersing stability and buffering capacity of the nanoparticles. The CS/PEI nanoparticles formed a complex upon mixing with a plasmid DNA of luciferase. The complex enhanced the level of gene transfection and prolonged the time period of expression for MSCs, compared with those of plasmid DNA-original CS and PEI nanoparticles. Cytotoxicity of CS/PEI complexes with plasmid DNA was significantly low, depending on the amount of PEI introduced. It is concluded that the CS/PEI nanoparticle was a promising carrier for gene delivery of MSCs. © 2010 Koninklijke Brill NV, Leiden.Publication Metadata only Prevalence of fractures among Thais with Thalassaemia syndromes(2010-10-01) W. Sutipornpalangkul; Y. Janechetsadatham; N. siritanaratkul; T. Harnroongroj; Mahidol UniversityIntroduction: The association of fractures with thalassaemia syndromes is well established. The aim of this study was to determine the prevalence and risk factors for fracture in Thai people with thalassaemia syndromes. Methods: A retrospective study and a patient interview were conducted in 201 Thai thalassaemia patients who attended the Division of Haematology, Department of Medicine Siriraj Hospital, Thailand. The patient interview questionnaire included sections on demographics, medical, orthopaedic and surgical history, usage of tobacco and alcohol, as well as questions that pertained to fracture. The risk factors for fracture were determined by odds ratio. Results: The prevalence of fracture in Thai people with thalassaemia syndromes was 35.3 percent. Fracture occurred more of ten in beta thalassaemia patients (44.1 percent) than in alpha thalassaemia patients (16.9 percent). Upper extremity was the most common site of fracture, while falls and motor vehicle accidents were the most common causes of fracture, and cast/splint was the most common choice of treatment. 28 percent of the patients sustained multiple fractures. Among alpha thalassaemia patients, adults sustained fractures more frequently than children and adolescents. In contrast, beta thalassaemia children had a greater rate of fracture than the adults and adolescents. The risk factors for fracture in thalassaemia patients included male gender, beta thalassaemia, splenectomy, transfusion and a low body mass index. Conclusion: A high prevalence of fracture is observed among Thais with thalassaemia. The aetiology was found to be multifactorial.Publication Metadata only Hb tak and Hb Q-Thailand in thai patients are S-window hemoglobin variants revealed by high performance liquid chromatography(2010-04-01) Sumalee Jindadamrongwech; Noppawan Tungbuppha; Suporn Chuncharunee; Punnee Butthep; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol UniversityThe S-window hemoglobin (Hb) variants revealed by high performance liquid chromatography (HPLC) were studied in 12 Thai individuals. The variants were identified, using DNA sequencing and multiplex amplification refractory mutation system-polymerase chain reaction (ARMS-PCR), to be six cases of Hb Tak [β147 (AC)], and six cases of Hb Q-Thailand [α74(EF3)Asp→His], respectively. By using the Capillarys 2-capillary zone electrophoresis (CE), Hb Tak and Hb Q-Thailand co-migrated with Hb F in zone 7. This might pose a problem as the high Hb F conditions suggest a differential diagnosis. The S-window Hb variants are mostly Hb Tak and Hb Q-Thailand in the Thai population rather than Hb S [β6(A3)Glu→Val]. The definite identification of Hb variants detected by HPLC or capillary electrophoresis (CE) requires DNA analysis. © Informa UK, Ltd.Publication Metadata only Nutritional supplements in health-conscious pre-/post-menopausal Thai women(2010-01-01) Pichai Leerasiri; Chenchit Chayachinda; Suchada Indhavivadhana; Thanyarat Wongwananurak; Chongdee Dangrat; Manee Rattanachaiyanont; Mahidol UniversityObjective: To survey prevalence, knowledge, attitude, and factors affecting the behavior of nutritional supplement consumption in health-conscious pre-/post-menopausal Thai women. Material and Method: A survey was conducted in 327 women, aged 40-67 years, who were new participants in the health promotion education program of Siriraj Menopause Clinic, Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, between January and July 2008. The participants completed a self-administering questionnaire inquiring their demographic data, attitude, knowledge, and behavior of supplement consumption. The participants were divided into three groups, i.e. current-, past-, and never-users, and then compared. Results: The majority (54.7%) of the presented participants consumed at least one kind of supplements, 37.3% and 17.4% were current-and past-users, respectively. The current-, past-, and never-users were not different in age, medical diseases, education levels, reading frequency, and economic status. The majority of participants obtained the information of supplements from newspaper or magazine. The users primarily purchased the supplements from hospitals or clinics. All participants had knowledge on health promotion and supplement products, however, 7.6% and 11.5% of such knowledge, respectively, was inaccurate. All participants had both positive and negative attitudes on supplement consumption, the negative attitude was found in 33.4% of the items tested. The never-users had trivial but statistically significant (p < 0.001) more accurate knowledge and more negative attitude than other groups had. Conclusion: More than 50% of health-conscious pre-/post-menopausal Thai women are ever-users of nutritional supplements. A lot of misunderstanding and misconception do exist even in the health-conscious women, regardless of their consumption behaviors. More education on this issue should be provided in order to reduce unnecessary expenditure and increase the efficiency of supplement consumption expenditure.Publication Metadata only Response from the authors(2010-09-01) Duangdao Nantakomol; Pornlada Nuchnoi; Chulalongkorn University; Mahidol UniversityPublication Metadata only A mechanism of ineffective erythropoiesis in β-thalassemia/Hb E disease(2010-05-01) Pathrapol Lithanatudom; Amporn Leecharoenkiat; Tirawat Wannatung; Saovaros Svasti; Suthat Fucharoen; Duncan R. Smith; Mahidol UniversityBackground Cells respond to stress stimuli through a number of response pathways, of which one of the most important and well characterized is the unfolded protein response. Despite a large body of work which suggests that stress in erythroblasts may play a pivotal role in the pathogenesis of β-thalassemia/Hb E disease, this pathway remains uninvestigated. Design and Methods Day 10 erythroblasts from normal controls and β-thalassemia/Hb E patients were subjected to internal (treatment with tunicamycin) and external (serum and growth factor withdrawal) stress stimuli and the activation of the unfolded protein response pathway was investigated. Results Normal erythroblasts responded to both internal and external stress by activating the unfolded protein response (UPR) pathway while in contrast, erythroblasts from β-thalassemia/Hb E patients only showed activation of the unfolded protein response pathway in response to internal stress. This was reflected by a markedly increased induction of apoptosis in serum and growth factor deprived β-thalassemia/Hb E erythroblasts as compared to control cells. Modulation of the levels of intracellular Ca2+ in thalassemic erythroblasts restored UPR activation during serum deprivation and significantly reduced the level of serum deprivation induced apoptosis to control levels. Conclusions These results suggest the failure of thalassemic erythroblasts to cope with cellular stress caused by an impaired UPR function as a result of high Ca2+ levels may exacerbate thalassemic cell death during erythropoiesis. © 2010 Ferrata Storti Foundation.Publication Metadata only Effects of prolactin and time delay on bone resorption: Mathematical modeling approach(2010-11-30) Chontita Rattanakul; Mahidol University; PERDOA mathematical model is developed in order to investigate the effect of prolactin on the mechanism of bone formation and resorption. By applying the singular perturbation technique to our model, we then obtain the explicit conditions on the system parameters which ensure the existence of limit cycle behavior corresponding to the oscillatory behavior observed in the clinical data. Numerical simulations are then carried out to support our theoretical analysis. In addition, we extend our model to investigate the effects of estrogen and parathyroid hormone supplements in patients with osteoporosis.Publication Metadata only Time duration to safety sitting in parturient receiving spinal anesthesia for cesarean section with 0.5% Bupivacaine and morphine(2010-06-01) Sahatsa Mandee; Arunotai Siriussawakul; Suwannee Suraseranivongse; Jongrak Khanwilai; Pongsak Nitigarun; Mahidol UniversityBackground: Spinal anesthesia has been used for cesarean section for a long time. However, the proportion of post-cesarean paturients who were able to sit at the fourth hour still remains unclear. Objective: Investigate the proportion of post-cesarean paturients that were able to sit at the fourth hour following spinal anesthesia with 0.5% hyperbaric bupivacaine and morphine. Furthermore, investigate the optimum time to encourage ambulation, and the risk factors delaying time duration to sit. Methods: A prospective observational study was conducted in 240 patients with American Society of Anesthesiologists physical status classification I and II, and single pregnancy parturients undergoing cesarean section. The patients who had body mass index (BMI) >35, estimated blood loss >1000 mL, needed postoperative bed rest, or received postoperative sedation were excluded. Hyperbaric bupivacaine 8-11 mg and morphine 0.2-0.3 mg were used. The patients were evaluated at the fourth hour until they could sit without adverse events or complete the sixth hour. All patients were evaluated for risk factors delaying the time duration to sit. Results: Out of 240 patients, 77.0%, 90.9%, and 98.4% were able to sit at the fourth, fifth, and sixth hour, respectively. The risk factors that delayed time to sit were Bromage scale >1 and pain score >3 by the univariate analysis, and were Bromage scale >1 and pain score >3 by the multivariate analysis. Conclusion: Seventy-seven percent of the patients could sit at the fourth hour, and most patients (98%) could sit at the sixth hour. The risk factors that delayed the time duration to sit were Bromage score >1 and pain score >3.Publication Metadata only The effect of different surface preparation techniques on the survival probabilities of orthodontic brackets bonded to nanofill composite resin(2010-09-01) Nita Viwattanatipa; Walaitip Jermwiwatkul; Rochaya Chintavalakorn; Nuntinee Nanthavanich; Mahidol UniversityObjective: To analyze the survival probabilities of different surface preparation techniques for bonding brackets to nanofill composite resin. Design: In vitro, laboratory study. Setting: Mahidol University, Bangkok, Thailand. Materials and methods: Thirty-five nanofill composite resin specimens/group were subjected to four surface preparation techniques as follows: (1) sandblast using aluminium oxide powder of 90 μm; (2) abrasion using diamond bur; (3) hydrofluoric acid etching for 2 min; and (4) 37% orthophosphoric acid etching for 30 s. Plastic conditioner was applied then brackets were bonded. Shear bond strength tests were carried out on a universal testing machine. Main outcome measures: Shear bond strength (MPa) and debonding force (N) were analyzed using Weibull analysis Results: The maximum stress and debonding force levels with a 95% probability of survival ranking from highest to lowest were: (1) sandblast group (4.2 MPa, 45.5 N); (2) diamond bur group (2.2 MPa, 25.3 N); (3) orthophosphoric group (1.9 MPa, 19.8 N); and (4) hydrofluoric group (0.8 MPa, 10.9 N). There was a significant difference in the adhesive remnant index scores between the surface preparation techniques (chi squared P< 0.001). Conclusion: Bonding orthodontic brackets to nanofill composite resin materials may result in lower bond strengths and special surface preparation techniques might be required to avoid increased numbers of bond failures. Surface treatment with sandblasting followed by plastic conditioner could increase the survival probability. The use of a diamond bur, orthophosphoric etching or hydrofluoric etching cannot be recommended. © 2010 British Orthodontic Society.Publication Metadata only Toxoplasma gondii: Simple duplex RT-PCR assay for detecting SAG1 and BAG1 genes during stage conversion in immunosuppressed mice(2010-02-01) Aongart Mahittikorn; Hannes Wickert; Yaowalark Sukthana; Mahidol University; Medical Laboratories Dr. Staber and Partner; Julius-Maximilians-Universitat WurzburgToxoplasmic encephalitis (TE) is caused by reactivation of dormant bradyzoites into rapidly dividing tachyzoites of the apicomplexan parasite Toxoplasma gondii in immune-compromised hosts. Diagnosis of this life-threatening disease is complicated, since it is difficult to distinguish between these two stages. It is, therefore, mainly based on a test positive for T. gondii antibodies, and specific clinical symptoms. We developed a duplex RT-PCR to detect the expression of bradyzoite (BAG1) and tachyzoite (SAG1) specific genes simultaneously during tachyzoite/bradyzoite stage conversion. The conversion reaction was observed in many organs of experimental mice, indicated by tachyzoites in the cerebrum, cerebellum, heart and lung, beginning in week 1 after the suppression period, and continuing until the end. Bradyzoites were also detected in nearly all organs throughout the study, suggesting that during the reactivation period, bradyzoites not only escape from cysts and reinvade neighboring cells as tachyzoites, but are also driven into developing new bradyzoites. The results of our study show that duplex RT-PCR is an easy, rapid, sensitive, and reproducible method, which is particularly valuable when numerous samples must be analyzed. This technique may usefully serve as an alternate tool for diagnosing TE in severely immunocompromised patients. © 2009 Elsevier Inc. All rights reserved.Publication Metadata only Performance assessment of technology transfer project: An application of DEA technique(2010-12-01) P. Punnakitikashem; P. Intarakumnerd; T. Laosirihongthong; Mahidol University; Thammasat UniversityTechnology transfer is a mechanism to acquire technology and helps company to enhance their technology capabilities. The purpose of this study is to demonstrate how Data Envelopment Analysis (DEA) can be used to assess performance of technology transfer project at firm level. Data collected from transferring the robotics operating technology project of 12 automotive parts/components manufacturing companies are examined by using the DEA model. The results of this study show that six companies carried out efficient technology transferring. The average efficiency score of technology transfer project is 93.3%. This finding confirms that absorptive capacity of recipient firms is a critical success factor underlying differences between efficient and inefficient firms. DEA method provides Chief Technology Officers (CTO) or project leaders a framework to determine appropriate transferring mechanisms and necessary internal and external resources. ©2010 IEEE.Publication Metadata only Up-regulation of erythropoietin receptor by nitric oxide mediates hypoxia preconditioning(2010-11-01) Zhi Yong Chen; Li Wang; Pundit Asavaritkrai; Constance Tom Noguchi; National Institute of Diabetes and Digestive and Kidney Diseases; Walter Reed Army Institute of Research; Mahidol UniversityErythropoietin (Epo), known to stimulate erythroid progenitor cell survival, proliferation, and differentiation, has been shown to be neuroprotective against brain ischemia in animal models. Both Epo and Epo receptor (EpoR) are expressed in the brain and are up-regulated by hypoxia. Brain Epo signaling can stimulate neural cell survival and prevent neuron apoptosis. Neurons from EpoR null mice exhibit marked increased sensitivity to hypoxia. In endothelial cells, Epo has been shown to stimulate nitric oxide (NO) production, particularly at low pO2. We found here that the EpoR expression on neural cells and Epo's neuroprotective effect were regulated by NO. Hypoxia increased NO production as well as EpoR expression, and inhibition of NOS activity reduced the proportion of EpoR-expressing neurons induced at low pO2. Conversely, addition of NO donor to cultures grown under normoxia induced EpoR. Similarly, NO donor increased EpoR promoter activity in a reporter gene assay, suggesting that NO regulates EpoR at the transcription level. Preincubation of neurons with NO results in induction of EpoR, which gives rise to protection against hypoxia even in the absence of exogenous Epo, although at high concentration NO is toxic. These data provide evidence of a role for NO in Epo activity in brain and suggest links between NO production, EpoR expression, and Epo signaling in neuroprotection. Published 2010 Wiley-Liss, Inc.Publication Metadata only Prevalence of metabolic syndrome in reproductive-aged polycystic ovary syndrome thai women(2010-06-01) Suchada Indhavivadhana; Thanyarat Wongwananuruk; Manee Rattanachaiyanont; Kitirat Techatraisak; Pichai Leerasiri; Prasong Tanmahasamut; Monrudee Popijan BNS; Mahidol UniversityObjective: To determine the prevalence of metabolic syndrome (MS) in reproductive-aged polycystic ovary syndrome (PCOS) Thai women. Material and Method: A Cross sectional study was done at the Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital of 250 PCOS Thai women who were diagnosed using Revised Rotterdam 2003 criteria, and who did not take medications affecting sex hormones or lipid metabolism, and attended the Gynecologic Endocrinology Unit between May 2007 and January 2009. Patents were interviewed and examined for weight, height, waist circumference, and blood pressure. Venous blood sample of each patient was drawn after 12-hour fasting. Prevalence of MS determined using the definitions of National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), International Diabetes Federation (IDF), and National Heart Lung and Blood Institutes/American Heart Association (NHLBI/ AHA). Results: Mean ± SD of age, body mass index (BMI), and waist circumference (WC) were 25.4 ± 5.8 years, 26.2 ± 7.6 kg/M2, and 82.3 ± 16.3 cm, respectively. Prevalence of MS by the definitions of NCEP ATP III, IDF, and NHLBI/AHA was 18.0%, 21.2%, and 21.2%, respectively. Of non-MS women, > 40% already had one to two criteria of IDF definition. Among MS women, 100% had central obesity, 50.9% had high blood pressure, 28.3% had impaired fasting blood glucose, 62.3% had hypertriglyceridemia, and 92.5% had high-density lipoprotein cholesterol < 50 mg/dL. The prevalence of MS increased from 10.3% in women aged < 20 years to 50.0% in those aged ≥ 40 years (p of trend = 0.003), and from 0.0% in women with BMI < 23 kg/M2 to 54.5% in those with BMI ≥ 30 kg/M2 (p of trend < 0.001). Conclusion: The prevalence of MS in reproductive-aged PCOS Thai women was 18.0% by NCEP ATP III and 21.2% by IDF and NHLBI/AHA. The prevalence varies only little with definitions of diagnostic criteria. The prevalence increases with age and body mass index. Slightly more than 40% of the non-MS PCOS Thai women already had one to two criteria of MS.Publication Metadata only Vision-based leaders and their followers in retail stores: Relationships and consequences in Australia(2010-11-01) Sooksan Kantabutra; Pisanu Vimolratana; Mahidol UniversityLeaders are exhorted to espouse vision, but little is known about how vision is used by leaders in Australian retail stores. The present study tested relationships between store manager passion for vision, motivation of staff and use of vision among staff, and leadership outcomes of staff and customer satisfaction in Australian apparel retail stores. Stores with vision are associated with higher staff satisfaction and more frequent use of vision among staff. Store manager passion directly predicts improvements in motivation of staff, use of vision among staff and staff satisfaction. Motivation of staff directly predicts enhanced staff satisfaction, while use of vision among staff directly predicts improved staff and customer satisfaction.