Browsing by Author "Fontana I.C."

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    Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives
    (2025-08-01) Iwatsubo T.; Sperling R.A.; Algeciras-Schimnich A.; Arai H.; Barron A.M.; Benzinger T.L.S.; Carrillo M.C.; Chen C.; Choi S.H.; Fontana I.C.; Graff-Radford J.; Grill J.D.; Heidebrink J.; Hu C.J.; Ihara R.; Ikeuchi T.; Iwata A.; Ip F.C.F.; Fitri F.I.; Jack C.R.; Jeong J.H.; Jia J.; Kandiah N.; Kim S.Y.; Kowa H.; La Joie R.; Niimi Y.; Noritake R.; Okonkwo O.C.; Palmqvist S.; Rafii M.S.; Raman R.; Shen Y.; Simuni T.; Snyder H.M.; Sriwannopas O.; Stoeckel L.E.; van der Flier W.M.; Wang H.; Wilcock D.M.; Zetterberg H.; Zhou J.; Mahinrad S.; Sexton C.E.; Iwatsubo T.; Mahidol University
    The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions—encompassing pharmacological and non-pharmacological strategies—and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. Highlights: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.