Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives
1
Issued Date
2025-08-01
Resource Type
ISSN
15525260
eISSN
15525279
Scopus ID
2-s2.0-105012409918
Journal Title
Alzheimer S and Dementia
Volume
21
Issue
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
Alzheimer S and Dementia Vol.21 No.8 (2025)
Suggested Citation
Iwatsubo T., Sperling R.A., Algeciras-Schimnich A., Arai H., Barron A.M., Benzinger T.L.S., Carrillo M.C., Chen C., Choi S.H., Fontana I.C., Graff-Radford J., Grill J.D., Heidebrink J., Hu C.J., Ihara R., Ikeuchi T., Iwata A., Ip F.C.F., Fitri F.I., Jack C.R., Jeong J.H., Jia J., Kandiah N., Kim S.Y., Kowa H., La Joie R., Niimi Y., Noritake R., Okonkwo O.C., Palmqvist S., Rafii M.S., Raman R., Shen Y., Simuni T., Snyder H.M., Sriwannopas O., Stoeckel L.E., van der Flier W.M., Wang H., Wilcock D.M., Zetterberg H., Zhou J., Mahinrad S., Sexton C.E. Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives. Alzheimer S and Dementia Vol.21 No.8 (2025). doi:10.1002/alz.70536 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111668
Title
Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives
Author(s)
Iwatsubo T.
Sperling R.A.
Algeciras-Schimnich A.
Arai H.
Barron A.M.
Benzinger T.L.S.
Carrillo M.C.
Chen C.
Choi S.H.
Fontana I.C.
Graff-Radford J.
Grill J.D.
Heidebrink J.
Hu C.J.
Ihara R.
Ikeuchi T.
Iwata A.
Ip F.C.F.
Fitri F.I.
Jack C.R.
Jeong J.H.
Jia J.
Kandiah N.
Kim S.Y.
Kowa H.
La Joie R.
Niimi Y.
Noritake R.
Okonkwo O.C.
Palmqvist S.
Rafii M.S.
Raman R.
Shen Y.
Simuni T.
Snyder H.M.
Sriwannopas O.
Stoeckel L.E.
van der Flier W.M.
Wang H.
Wilcock D.M.
Zetterberg H.
Zhou J.
Mahinrad S.
Sexton C.E.
Sperling R.A.
Algeciras-Schimnich A.
Arai H.
Barron A.M.
Benzinger T.L.S.
Carrillo M.C.
Chen C.
Choi S.H.
Fontana I.C.
Graff-Radford J.
Grill J.D.
Heidebrink J.
Hu C.J.
Ihara R.
Ikeuchi T.
Iwata A.
Ip F.C.F.
Fitri F.I.
Jack C.R.
Jeong J.H.
Jia J.
Kandiah N.
Kim S.Y.
Kowa H.
La Joie R.
Niimi Y.
Noritake R.
Okonkwo O.C.
Palmqvist S.
Rafii M.S.
Raman R.
Shen Y.
Simuni T.
Snyder H.M.
Sriwannopas O.
Stoeckel L.E.
van der Flier W.M.
Wang H.
Wilcock D.M.
Zetterberg H.
Zhou J.
Mahinrad S.
Sexton C.E.
Author's Affiliation
Harvard Medical School
University College London
University of Science and Technology of China
Mayo Clinic
UCSF School of Medicine
University of California, Irvine
Northwestern University Feinberg School of Medicine
Vrije Universiteit Amsterdam
Keck School of Medicine of USC
Hong Kong University of Science and Technology
Indiana University School of Medicine
University of Wisconsin School of Medicine and Public Health
Skånes Universitetssjukhus
Kobe University
Okayama University
Michigan Medicine
Sahlgrenska Universitetssjukhuset
Sahlgrenska Akademin
NUS Yong Loo Lin School of Medicine
UCL Queen Square Institute of Neurology
Graduate School of Medicine
Seoul National University Bundang Hospital
Mayo Clinic College of Medicine and Science
National Institute on Aging (NIA)
Xuanwu Hospital, Capital Medical University
Universitas Sumatera Utara
Mallinckrodt Institute of Radiology
School of Medicine
The University of Tokyo Hospital
Ewha Womans University School of Medicine
Ramathibodi Hospital
Lee Kong Chian School of Medicine
College of Medicine
Taipei Medical University Shuang-Ho Hospital
National Center for Geriatrics and Gerontology
Institutionen för Kliniska Vetenskaper, Malmö
Amsterdam Neuroscience
Brain Research Institute
Peking University Sixth Hospital
Eisai Inc.
National Healthcare Group Pte Ltd
Alzheimer's Association
Tokyo Metropolitan Institute for Geriatrics and Gerontology
InnoHK
Otemachi One Tower
University College London
University of Science and Technology of China
Mayo Clinic
UCSF School of Medicine
University of California, Irvine
Northwestern University Feinberg School of Medicine
Vrije Universiteit Amsterdam
Keck School of Medicine of USC
Hong Kong University of Science and Technology
Indiana University School of Medicine
University of Wisconsin School of Medicine and Public Health
Skånes Universitetssjukhus
Kobe University
Okayama University
Michigan Medicine
Sahlgrenska Universitetssjukhuset
Sahlgrenska Akademin
NUS Yong Loo Lin School of Medicine
UCL Queen Square Institute of Neurology
Graduate School of Medicine
Seoul National University Bundang Hospital
Mayo Clinic College of Medicine and Science
National Institute on Aging (NIA)
Xuanwu Hospital, Capital Medical University
Universitas Sumatera Utara
Mallinckrodt Institute of Radiology
School of Medicine
The University of Tokyo Hospital
Ewha Womans University School of Medicine
Ramathibodi Hospital
Lee Kong Chian School of Medicine
College of Medicine
Taipei Medical University Shuang-Ho Hospital
National Center for Geriatrics and Gerontology
Institutionen för Kliniska Vetenskaper, Malmö
Amsterdam Neuroscience
Brain Research Institute
Peking University Sixth Hospital
Eisai Inc.
National Healthcare Group Pte Ltd
Alzheimer's Association
Tokyo Metropolitan Institute for Geriatrics and Gerontology
InnoHK
Otemachi One Tower
Corresponding Author(s)
Other Contributor(s)
Abstract
The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions—encompassing pharmacological and non-pharmacological strategies—and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. Highlights: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.