Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives

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dc.contributor.authorIwatsubo T.
dc.contributor.authorSperling R.A.
dc.contributor.authorAlgeciras-Schimnich A.
dc.contributor.authorArai H.
dc.contributor.authorBarron A.M.
dc.contributor.authorBenzinger T.L.S.
dc.contributor.authorCarrillo M.C.
dc.contributor.authorChen C.
dc.contributor.authorChoi S.H.
dc.contributor.authorFontana I.C.
dc.contributor.authorGraff-Radford J.
dc.contributor.authorGrill J.D.
dc.contributor.authorHeidebrink J.
dc.contributor.authorHu C.J.
dc.contributor.authorIhara R.
dc.contributor.authorIkeuchi T.
dc.contributor.authorIwata A.
dc.contributor.authorIp F.C.F.
dc.contributor.authorFitri F.I.
dc.contributor.authorJack C.R.
dc.contributor.authorJeong J.H.
dc.contributor.authorJia J.
dc.contributor.authorKandiah N.
dc.contributor.authorKim S.Y.
dc.contributor.authorKowa H.
dc.contributor.authorLa Joie R.
dc.contributor.authorNiimi Y.
dc.contributor.authorNoritake R.
dc.contributor.authorOkonkwo O.C.
dc.contributor.authorPalmqvist S.
dc.contributor.authorRafii M.S.
dc.contributor.authorRaman R.
dc.contributor.authorShen Y.
dc.contributor.authorSimuni T.
dc.contributor.authorSnyder H.M.
dc.contributor.authorSriwannopas O.
dc.contributor.authorStoeckel L.E.
dc.contributor.authorvan der Flier W.M.
dc.contributor.authorWang H.
dc.contributor.authorWilcock D.M.
dc.contributor.authorZetterberg H.
dc.contributor.authorZhou J.
dc.contributor.authorMahinrad S.
dc.contributor.authorSexton C.E.
dc.contributor.correspondenceIwatsubo T.
dc.contributor.otherMahidol University
dc.date.accessioned2025-08-15T18:36:24Z
dc.date.available2025-08-15T18:36:24Z
dc.date.issued2025-08-01
dc.description.abstractThe landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions—encompassing pharmacological and non-pharmacological strategies—and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. Highlights: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.
dc.identifier.citationAlzheimer S and Dementia Vol.21 No.8 (2025)
dc.identifier.doi10.1002/alz.70536
dc.identifier.eissn15525279
dc.identifier.issn15525260
dc.identifier.scopus2-s2.0-105012409918
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/111668
dc.rights.holderSCOPUS
dc.subjectNeuroscience
dc.subjectMedicine
dc.titleModernizing diagnosis of Alzheimer's disease: A review of global trends and Asia-specific perspectives
dc.typeReview
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105012409918&origin=inward
oaire.citation.issue8
oaire.citation.titleAlzheimer S and Dementia
oaire.citation.volume21
oairecerif.author.affiliationHarvard Medical School
oairecerif.author.affiliationUniversity College London
oairecerif.author.affiliationUniversity of Science and Technology of China
oairecerif.author.affiliationMayo Clinic
oairecerif.author.affiliationUCSF School of Medicine
oairecerif.author.affiliationUniversity of California, Irvine
oairecerif.author.affiliationNorthwestern University Feinberg School of Medicine
oairecerif.author.affiliationVrije Universiteit Amsterdam
oairecerif.author.affiliationKeck School of Medicine of USC
oairecerif.author.affiliationHong Kong University of Science and Technology
oairecerif.author.affiliationIndiana University School of Medicine
oairecerif.author.affiliationUniversity of Wisconsin School of Medicine and Public Health
oairecerif.author.affiliationSkånes Universitetssjukhus
oairecerif.author.affiliationKobe University
oairecerif.author.affiliationOkayama University
oairecerif.author.affiliationMichigan Medicine
oairecerif.author.affiliationSahlgrenska Universitetssjukhuset
oairecerif.author.affiliationSahlgrenska Akademin
oairecerif.author.affiliationNUS Yong Loo Lin School of Medicine
oairecerif.author.affiliationUCL Queen Square Institute of Neurology
oairecerif.author.affiliationGraduate School of Medicine
oairecerif.author.affiliationSeoul National University Bundang Hospital
oairecerif.author.affiliationMayo Clinic College of Medicine and Science
oairecerif.author.affiliationNational Institute on Aging (NIA)
oairecerif.author.affiliationXuanwu Hospital, Capital Medical University
oairecerif.author.affiliationUniversitas Sumatera Utara
oairecerif.author.affiliationMallinckrodt Institute of Radiology
oairecerif.author.affiliationSchool of Medicine
oairecerif.author.affiliationThe University of Tokyo Hospital
oairecerif.author.affiliationEwha Womans University School of Medicine
oairecerif.author.affiliationRamathibodi Hospital
oairecerif.author.affiliationLee Kong Chian School of Medicine
oairecerif.author.affiliationCollege of Medicine
oairecerif.author.affiliationTaipei Medical University Shuang-Ho Hospital
oairecerif.author.affiliationNational Center for Geriatrics and Gerontology
oairecerif.author.affiliationInstitutionen för Kliniska Vetenskaper, Malmö
oairecerif.author.affiliationAmsterdam Neuroscience
oairecerif.author.affiliationBrain Research Institute
oairecerif.author.affiliationPeking University Sixth Hospital
oairecerif.author.affiliationEisai Inc.
oairecerif.author.affiliationNational Healthcare Group ​Pte Ltd
oairecerif.author.affiliationAlzheimer's Association
oairecerif.author.affiliationTokyo Metropolitan Institute for Geriatrics and Gerontology
oairecerif.author.affiliationInnoHK
oairecerif.author.affiliationOtemachi One Tower

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