Browsing by Author "Harapan Kita Cardiovascular Hospital"

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    Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands
    (2013-11-01) Dae Hun Kim; Ji Young Choi; Hae Won Kim; So Hyun Kim; Doo Ryeon Chung; Kyong Ran Peck; Visanu Thamlikitkul; Thomas Man Kit So; Rohani M.D. Yasin; Po Ren Hsueh; Celia C. Carlos; Li Yang Hsu; Latre Buntaran; M. K. Lalitha; Jae Hoon Song; Kwan Soo Ko; SungKyunKwan University, School of Medicine; Asia Pacific Foundation for Infectious Diseases (APFID); Mahidol University; Princess Margaret Hospital Hong Kong; Institute for Medical Research Kuala Lumpur; National Taiwan University Hospital; Gokila; National University Hospital, Singapore; Harapan Kita Cardiovascular Hospital; Department of Microbiology; SureCare Medical Centre
    In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaRtype resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenemresistant A. baumannii in Asia. Copyright © 2013, American Society for Microbiology. All Rights Reserved.