Publication: Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands
item.page.dc.date.issued
2013-11-01
item.page.dc.type
item.page.dc.identifier.issn
10986596
00664804
00664804
item.page.dc.identifier.doi
item.page.dc.identifier.other
2-s2.0-84885921183
item.page.dc.rights
Mahidol University
item.page.dc.rights.holder
SCOPUS
item.page.dc.identifier.citation
Antimicrobial Agents and Chemotherapy. Vol.57, No.11 (2013), 5239-5246
punsarn.item.page.citation
Dae Hun Kim, Ji Young Choi, Hae Won Kim, So Hyun Kim, Doo Ryeon Chung, Kyong Ran Peck, Visanu Thamlikitkul, Thomas Man Kit So, Rohani M.D. Yasin, Po Ren Hsueh, Celia C. Carlos, Li Yang Hsu, Latre Buntaran, M. K. Lalitha, Jae Hoon Song, Kwan Soo Ko Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands. Antimicrobial Agents and Chemotherapy. Vol.57, No.11 (2013), 5239-5246. doi:10.1128/AAC.00633-13 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32102
Research Projects
Organizational Units
Authors
Journal Issue
relationships.isThesisOf
item.page.dc.title
Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands
item.page.dc.contributor.other
SungKyunKwan University, School of Medicine
Asia Pacific Foundation for Infectious Diseases (APFID)
Mahidol University
Princess Margaret Hospital Hong Kong
Institute for Medical Research Kuala Lumpur
National Taiwan University Hospital
Gokila
National University Hospital, Singapore
Harapan Kita Cardiovascular Hospital
Department of Microbiology
SureCare Medical Centre
Asia Pacific Foundation for Infectious Diseases (APFID)
Mahidol University
Princess Margaret Hospital Hong Kong
Institute for Medical Research Kuala Lumpur
National Taiwan University Hospital
Gokila
National University Hospital, Singapore
Harapan Kita Cardiovascular Hospital
Department of Microbiology
SureCare Medical Centre
item.page.dc.description.abstract
In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaRtype resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenemresistant A. baumannii in Asia. Copyright © 2013, American Society for Microbiology. All Rights Reserved.