Browsing by Author "Istituto Toscano Tumori"

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    Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common
    (2012-12-18) Nicholas J. White; Li Guo Qiao; Gao Qi; Lucio Luzzatto; Mahidol University; Guangzhou University; Jiangsu Institute of Parasitic Diseases; Istituto Toscano Tumori
    In areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg; 45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria transmission. Review of studies of transmission-blocking activity based on the infectivity of patients or volunteers to anopheline mosquitoes, and of haemolytic toxicity in glucose 6-dehydrogenase (G6PD) deficient subjects, suggests that a lower primaquine dose (0.25 mg base/kg) would be safer and equally effective. This lower dose could be deployed together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated. © 2012 White et al.; licensee BioMed Central Ltd.