Publication:
Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

Issued Date

2012-12-18

Resource Type

Article

ISSN

14752875

DOI

10.1186/1475-2875-11-418

Other identifier(s)

2-s2.0-84870891528

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Malaria Journal. Vol.11, (2012)

Suggested Citation

Nicholas J. White, Li Guo Qiao, Gao Qi, Lucio Luzzatto Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common. Malaria Journal. Vol.11, (2012). doi:10.1186/1475-2875-11-418 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14225

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Title

Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

Author(s)

Nicholas J. White
 Li Guo Qiao
 Gao Qi
 Lucio Luzzatto

Other Contributor(s)

Mahidol University
 Guangzhou University
 Jiangsu Institute of Parasitic Diseases
 Istituto Toscano Tumori

Abstract

In areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg; 45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria transmission. Review of studies of transmission-blocking activity based on the infectivity of patients or volunteers to anopheline mosquitoes, and of haemolytic toxicity in glucose 6-dehydrogenase (G6PD) deficient subjects, suggests that a lower primaquine dose (0.25 mg base/kg) would be safer and equally effective. This lower dose could be deployed together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated. © 2012 White et al.; licensee BioMed Central Ltd.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/14225

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Scopus 2011-2015