Browsing by Author "Lampang Ra-jabhat University"

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    Chemical composition and biological activities of croton delpyi, croton decalvatus and croton caudatus
    (2021-01-01) Sakchai Chaibun; Wilart Pompimon; Chanika Tidchai; Noraset Chalaemwongwan; Jutarut Wongping; Chidawan Kansorn; Phansuang Udomputtimekakul; Puttinan Meepowpan; Siriporn Jungsuttiwong; Sarinya Hadsadee; Suttiporn Pikulthong; Narong Nuntasaen; Thailand Ministry of Natural Resources and Environment; Ubon Ratchathani University; Mahidol University; Chiang Mai University; Lampang Ra-jabhat University
    Background: C. delpyi, C. decalvatus and C. caudatus are in the Euphorbiaceae family. The aerial parts, such as twigs, leaves and barks of these plants are used as traditional medicine such as anti-inflammatory, cytotoxicity, and antifungal properties. Objectives: The aims of this work were 1) to study the chemical composition of C. delpyi, C. decal-vatus, and C. caudatus 2) to test the antibacterial, anti-HIV-1 RT, and cytotoxicity activities of crude extracts and pure compounds from these plants. Methods: Extraction, separation and purification of three plants were performed following chroma-tographic method. The biological activities, including antibacterial, anti-HIV-1 RT and cytotoxicity assay of three plants, were evaluated by the standard methods. Results: Phytochemical investigation of C. delpyi highlighted a new clerodane diterpenoid; cro-tondelpyitin A (1). The five known compounds were found, such as acetyl aleuritolic acid (2), 5-hydroxy-7,4′-dimethoxyflavone (3), and pilloin (4) in C. decalvatus and 3α-benzoyloxy-D while A-friedo-oleanan-27,16α-lactone (5), and bergenin (6) in C. caudatus. Compound 3 showed the most effective antibacterial activities with MIC in range <0.16-1.25 mg/mL, and MBC in range 0.6->5.0 mg/mL. The six compounds were inactive with anti-HIV-1 RT. In addition, compound 4 was active for cytotoxic activities on FaDu and KKU-M213 at <4 µg/mL. Conclusion: The present study reveals that the Croton species are sources of diterpenoid-type compounds and a significant guide for further research of chemical constituents from these plants as potential medicines.