Publication: Chemical composition and biological activities of croton delpyi, croton decalvatus and croton caudatus
Issued Date
2021-01-01
Resource Type
ISSN
22103163
22103155
22103155
Other identifier(s)
2-s2.0-85120606386
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Products Journal. Vol.11, No.4 (2021), 559-568
Suggested Citation
Sakchai Chaibun, Wilart Pompimon, Chanika Tidchai, Noraset Chalaemwongwan, Jutarut Wongping, Chidawan Kansorn, Phansuang Udomputtimekakul, Puttinan Meepowpan, Siriporn Jungsuttiwong, Sarinya Hadsadee, Suttiporn Pikulthong, Narong Nuntasaen Chemical composition and biological activities of croton delpyi, croton decalvatus and croton caudatus. Natural Products Journal. Vol.11, No.4 (2021), 559-568. doi:10.2174/2210315510999200704143606 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78550
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Title
Chemical composition and biological activities of croton delpyi, croton decalvatus and croton caudatus
Abstract
Background: C. delpyi, C. decalvatus and C. caudatus are in the Euphorbiaceae family. The aerial parts, such as twigs, leaves and barks of these plants are used as traditional medicine such as anti-inflammatory, cytotoxicity, and antifungal properties. Objectives: The aims of this work were 1) to study the chemical composition of C. delpyi, C. decal-vatus, and C. caudatus 2) to test the antibacterial, anti-HIV-1 RT, and cytotoxicity activities of crude extracts and pure compounds from these plants. Methods: Extraction, separation and purification of three plants were performed following chroma-tographic method. The biological activities, including antibacterial, anti-HIV-1 RT and cytotoxicity assay of three plants, were evaluated by the standard methods. Results: Phytochemical investigation of C. delpyi highlighted a new clerodane diterpenoid; cro-tondelpyitin A (1). The five known compounds were found, such as acetyl aleuritolic acid (2), 5-hydroxy-7,4′-dimethoxyflavone (3), and pilloin (4) in C. decalvatus and 3α-benzoyloxy-D while A-friedo-oleanan-27,16α-lactone (5), and bergenin (6) in C. caudatus. Compound 3 showed the most effective antibacterial activities with MIC in range <0.16-1.25 mg/mL, and MBC in range 0.6->5.0 mg/mL. The six compounds were inactive with anti-HIV-1 RT. In addition, compound 4 was active for cytotoxic activities on FaDu and KKU-M213 at <4 µg/mL. Conclusion: The present study reveals that the Croton species are sources of diterpenoid-type compounds and a significant guide for further research of chemical constituents from these plants as potential medicines.