Browsing by Author "Nguyen T.N.T."

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    Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
    (2022-12-01) Zhu L.; van der Pluijm R.W.; Kucharski M.; Nayak S.; Tripathi J.; White N.J.; Day N.P.J.; Faiz A.; Phyo A.P.; Amaratunga C.; Lek D.; Ashley E.A.; Nosten F.; Smithuis F.; Ginsburg H.; von Seidlein L.; Lin K.; Imwong M.; Chotivanich K.; Mayxay M.; Dhorda M.; Nguyen H.C.; Nguyen T.N.T.; Miotto O.; Newton P.N.; Jittamala P.; Tripura R.; Pukrittayakamee S.; Peto T.J.; Hien T.T.; Dondorp A.M.; Bozdech Z.; Mahidol University
    The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016–2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.