Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Issued Date
2022-12-01
Resource Type
eISSN
23993642
Scopus ID
2-s2.0-85127289697
Pubmed ID
35347215
Journal Title
Communications Biology
Volume
5
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Communications Biology Vol.5 No.1 (2022)
Suggested Citation
Zhu L., van der Pluijm R.W., Kucharski M., Nayak S., Tripathi J., White N.J., Day N.P.J., Faiz A., Phyo A.P., Amaratunga C., Lek D., Ashley E.A., Nosten F., Smithuis F., Ginsburg H., von Seidlein L., Lin K., Imwong M., Chotivanich K., Mayxay M., Dhorda M., Nguyen H.C., Nguyen T.N.T., Miotto O., Newton P.N., Jittamala P., Tripura R., Pukrittayakamee S., Peto T.J., Hien T.T., Dondorp A.M., Bozdech Z. Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response. Communications Biology Vol.5 No.1 (2022). doi:10.1038/s42003-022-03215-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83087
Title
Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Author(s)
Zhu L.
van der Pluijm R.W.
Kucharski M.
Nayak S.
Tripathi J.
White N.J.
Day N.P.J.
Faiz A.
Phyo A.P.
Amaratunga C.
Lek D.
Ashley E.A.
Nosten F.
Smithuis F.
Ginsburg H.
von Seidlein L.
Lin K.
Imwong M.
Chotivanich K.
Mayxay M.
Dhorda M.
Nguyen H.C.
Nguyen T.N.T.
Miotto O.
Newton P.N.
Jittamala P.
Tripura R.
Pukrittayakamee S.
Peto T.J.
Hien T.T.
Dondorp A.M.
Bozdech Z.
van der Pluijm R.W.
Kucharski M.
Nayak S.
Tripathi J.
White N.J.
Day N.P.J.
Faiz A.
Phyo A.P.
Amaratunga C.
Lek D.
Ashley E.A.
Nosten F.
Smithuis F.
Ginsburg H.
von Seidlein L.
Lin K.
Imwong M.
Chotivanich K.
Mayxay M.
Dhorda M.
Nguyen H.C.
Nguyen T.N.T.
Miotto O.
Newton P.N.
Jittamala P.
Tripura R.
Pukrittayakamee S.
Peto T.J.
Hien T.T.
Dondorp A.M.
Bozdech Z.
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
Oxford University Clinical Research Unit
School of Biological Sciences
Ministry of Health Laos
University of Oxford
National Institute of Allergy and Infectious Diseases (NIAID)
Mahosot Hospital, Lao
Nuffield Department of Medicine
Hebrew University of Jerusalem
Wellcome Sanger Institute
Universiteit van Amsterdam
Myanmar Oxford Clinical Research Unit
Ramu Upazila Health Complex
Malaria Research Group and Dev Care Foundation
WorldWide Antimalarial Resistance Network – Asia-Pacific Regional Centre
Royal Society of Thailand
National Centre for Parasitology
Oxford University Clinical Research Unit
School of Biological Sciences
Ministry of Health Laos
University of Oxford
National Institute of Allergy and Infectious Diseases (NIAID)
Mahosot Hospital, Lao
Nuffield Department of Medicine
Hebrew University of Jerusalem
Wellcome Sanger Institute
Universiteit van Amsterdam
Myanmar Oxford Clinical Research Unit
Ramu Upazila Health Complex
Malaria Research Group and Dev Care Foundation
WorldWide Antimalarial Resistance Network – Asia-Pacific Regional Centre
Royal Society of Thailand
National Centre for Parasitology
Other Contributor(s)
Abstract
The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016–2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.