Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

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dc.contributor.authorZhu L.
dc.contributor.authorvan der Pluijm R.W.
dc.contributor.authorKucharski M.
dc.contributor.authorNayak S.
dc.contributor.authorTripathi J.
dc.contributor.authorWhite N.J.
dc.contributor.authorDay N.P.J.
dc.contributor.authorFaiz A.
dc.contributor.authorPhyo A.P.
dc.contributor.authorAmaratunga C.
dc.contributor.authorLek D.
dc.contributor.authorAshley E.A.
dc.contributor.authorNosten F.
dc.contributor.authorSmithuis F.
dc.contributor.authorGinsburg H.
dc.contributor.authorvon Seidlein L.
dc.contributor.authorLin K.
dc.contributor.authorImwong M.
dc.contributor.authorChotivanich K.
dc.contributor.authorMayxay M.
dc.contributor.authorDhorda M.
dc.contributor.authorNguyen H.C.
dc.contributor.authorNguyen T.N.T.
dc.contributor.authorMiotto O.
dc.contributor.authorNewton P.N.
dc.contributor.authorJittamala P.
dc.contributor.authorTripura R.
dc.contributor.authorPukrittayakamee S.
dc.contributor.authorPeto T.J.
dc.contributor.authorHien T.T.
dc.contributor.authorDondorp A.M.
dc.contributor.authorBozdech Z.
dc.contributor.otherMahidol University
dc.date.accessioned2023-06-18T16:33:40Z
dc.date.available2023-06-18T16:33:40Z
dc.date.issued2022-12-01
dc.description.abstractThe emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016–2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.
dc.identifier.citationCommunications Biology Vol.5 No.1 (2022)
dc.identifier.doi10.1038/s42003-022-03215-0
dc.identifier.eissn23993642
dc.identifier.pmid35347215
dc.identifier.scopus2-s2.0-85127289697
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/83087
dc.rights.holderSCOPUS
dc.subjectAgricultural and Biological Sciences
dc.titleArtemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85127289697&origin=inward
oaire.citation.issue1
oaire.citation.titleCommunications Biology
oaire.citation.volume5
oairecerif.author.affiliationFaculty of Tropical Medicine, Mahidol University
oairecerif.author.affiliationOxford University Clinical Research Unit
oairecerif.author.affiliationSchool of Biological Sciences
oairecerif.author.affiliationMinistry of Health Laos
oairecerif.author.affiliationUniversity of Oxford
oairecerif.author.affiliationNational Institute of Allergy and Infectious Diseases (NIAID)
oairecerif.author.affiliationMahosot Hospital, Lao
oairecerif.author.affiliationNuffield Department of Medicine
oairecerif.author.affiliationHebrew University of Jerusalem
oairecerif.author.affiliationWellcome Sanger Institute
oairecerif.author.affiliationUniversiteit van Amsterdam
oairecerif.author.affiliationMyanmar Oxford Clinical Research Unit
oairecerif.author.affiliationRamu Upazila Health Complex
oairecerif.author.affiliationMalaria Research Group and Dev Care Foundation
oairecerif.author.affiliationWorldWide Antimalarial Resistance Network – Asia-Pacific Regional Centre
oairecerif.author.affiliationRoyal Society of Thailand
oairecerif.author.affiliationNational Centre for Parasitology

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