Browsing by Author "Niramon Utama-Ang"

Filter results by typing the first few letters
Now showing 1 - 3 of 3
  • No Thumbnail Available
    PublicationMetadata only
    Antioxidant effects of anthocyanin-rich riceberry™ rice flour prepared using dielectric barrier discharge plasma technology on iron-induced oxidative stress in mice
    (2021-08-02) Natwalinkhol Settapramote; Niramon Utama-Ang; Touchwin Petiwathayakorn; Kornvipa Settakorn; Saovaros Svasti; Somdet Srichairatanakool; Pimpisid Koonyosying; Rajamangala University of Technology Isan; Institute of Molecular Biosciences, Mahidol University; Chiang Mai University
    Redox-active iron generates reactive oxygen species that can cause oxidative organ dysfunction. Thus, the anti-oxidative systems in the body and certain dietary antioxidants, such as anthocyanins, are needed to control oxidative stress. We aimed to investigate the effects of dielectric barrier discharge (DBD) plasma technology in the preparation of Riceberry™ rice flour (PRBF) on iron-induced oxidative stress in mice. PRBF using plasma technology was rich in anthocyanins, mainly cyanidine-3-glucoside and peonidine-3-glucoside. PRBF (5 mg AE/mg) lowered WBC numbers in iron dextran (FeDex)-loaded mice and served as evidence of the reversal of erythrocyte superoxide dismutase activity, plasma total antioxidant capacity, and plasma and liver thiobarbituric acid-reactive substances in the loading mice. Consequently, the PRBF treatment was observed to be more effective than NAC treatment. PRBF would be a powerful supplementary and therapeutic antioxidant product that is understood to be more potent than NAC in ameliorating the effects of iron-induced oxidative stress.
  • No Thumbnail Available
    PublicationMetadata only
    Consumption of a green tea extract-curcumin drink decreases blood urea nitrogen and redox iron in β-thalassemia patients
    (2020-01-01) Pimpisid Koonyosying; Adisak Tantiworawit; Sasinee Hantrakool; Niramon Utama-Ang; Michael Cresswell; Suthat Fucharoen; John B. Porter; Somdet Srichairatanakool; UCL; Mahidol University; Chiang Mai University
    © The Royal Society of Chemistry 2020. The most important cause of death in β-thalassemia major patients is organ dysfunction due to iron deposits. Non-transferrin bound iron (NTBI), labile plasma iron (LPI) and labile iron pool are redox-active forms of iron found in thalassemia. Iron chelation therapy is adopted to counteract the resulting iron overload. Extracts of green tea (GTE) and curcumin exhibit iron-chelating and antioxidant activities in iron-loaded cells and β-thalassemic mice. We have used our GTE-CUR drink to investigate the potential amelioration of iron overload and oxidative stress in transfusion-dependent β-thalassemia (TDT) patients. The patients were enrolled for a control group without and with GTE-CUR treatments (17.3 and 35.5 mg EGCG equivalent). Along with regular chelation therapy, they were daily administered the drink for 60 d. Blood samples were collected at the beginning of the study and after 30 d and 60 d for biochemical and hematological tests. Interestingly, we found a decrease of blood urea nitrogen levels (P < 0.05), along with a tendency for a decrease of NTBI and LPI, and a delay in increasing lipid-peroxidation product levels in the GTE-CUR groups. The findings suggest that GTE-CUR could increase kidney function and diminish redox-active iron in iron overloaded β-thalassemia patients.
  • No Thumbnail Available
    PublicationMetadata only
    Consumption of sinlek rice drink improved red cell indices in anemic elderly subjects
    (2021-10-02) Peerasak Lerttrakarnnon; Winthana Kusirisin; Pimpisid Koonyosying; Ben Flemming; Niramon Utama-Ang; Suthat Fucharoen; Somdet Srichairatanakool; Faculty of Science and Engineering; Institute of Molecular Biosciences, Mahidol University; Chiang Mai University
    Iron fortifications are used for the treatment of iron-deficiency anemia; however, iron dos-ing may cause oxidative damage to the gut lumen. Thai Sinlek rice is abundant in iron and contains phytochemicals. We aimed at evaluating the effect of an iron-rice (IR) hydrolysate drink (100 mL/serving) on neurological function, red cell indices and iron status in elders. Healthy elderly subjects were divided into three non-anemic groups and one anemic group. The non-anemic groups consumed one WR (2 mg iron/serving) and two IR drinks (15 and 27 mg iron/serving) (groups A, B and D, respectively), while the anemic group consumed one IR drink (15 mg iron serving) (group C) every day for 30 days. There were no significant differences in the MMSE Thai 2002 and PHQ9 test scores for members of all groups, while the nutrition scores and body weight values of group D subjects were significantly increased. Hemoglobin (Hb) and mean corpuscular hemoglobin concentrations increased significantly only in group C. Serum iron and transferrin saturation levels tended to increase in group A, while these levels were decreased in members of group C. Serum antioxidant activity levels were increased in all groups, and were highest in group C. Thus, consumption of an IR drink for 15 days functioned to increase Hb and antioxidant capacity levels in anemic elders.