Browsing by Author "Olay Lattana"

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    Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR
    (2012-09-01) Ampai Tanganuchitcharnchai; Lee Smythe; Michael Dohnt; Rudy Hartskeerl; Manivanh Vongsouvath; Viengmone Davong; Olay Lattana; Paul N. Newton; Stuart D. Blacksell; Mahidol University; World Health Organization, Australia; Royal Tropical Institute - KIT; Mahosot Hospital; University of Oxford
    The diagnostic utility of the Standard Diagnostics . Leptospira IgM ELISA for detection of acute leptospirosis was assessed in febrile adults admitted in Vientiane, Laos. Using the cut-off suggested by the manufacturer [optical density (OD) ≥0.75], the assay demonstrated limited diagnostic capacity with a sensitivity of 95% and a specificity of 41% compared with the . Leptospira microscopic agglutination test, which is the serological gold standard. However, re-evaluation of the diagnostic cut-off to an OD of 1.7 demonstrated improved diagnostic accuracy overall (sensitivity 70%; specificity 78%). © 2012 Royal Society of Tropical Medicine and Hygiene.
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    Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin M antibodies in Laos
    (2006-10-01) Stuart D. Blacksell; Lee Smythe; Rattanaphone Phetsouvanh; Michael Dohnt; Rudy Hartskeerl; Meegan Symonds; Andrew Slack; Manivanh Vongsouvath; Viengmone Davong; Olay Lattana; Simmaly Phongmany; Valy Keolouangkot; Nicholas J. White; Nicholas P.J. Day; Paul N. Newton; Mahosot Hospital; University of Oxford; Mahidol University; World Health Organization, Australia; Royal Tropical Institute - KIT
    The diagnostic utility of immunochromatographic (Leptotek) and enzyme-linked immunosorbent assay (ELISA; Panbio) tests for the detection of Leptospira immunoglobulin M antibodies was assessed in febrile adults admitted in Vientiane, Laos. Both tests demonstrated poor diagnostic accuracy using admission serum (Leptotek sensitivity of 47.3% and specificity of 75.5%: ELISA sensitivity of 60.9% and specificity of 65.6%) compared to the Leptospira "gold standard" microscopic agglutination test. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
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    Management of central nervous system infections, Vientiane, Laos, 2003–2011
    (2019-05-01) Audrey Dubot-Pérès; Mayfong Mayxay; Rattanaphone Phetsouvanh; Sue J. Lee; Sayaphet Rattanavong; Manivanh Vongsouvath; Viengmon Davong; Vilada Chansamouth; Koukeo Phommasone; Catrin Moore; Sabine Dittrich; Olay Lattana; Joy Sirisouk; Phonelavanh Phoumin; Phonepasith Panyanivong; Amphonesavanh Sengduangphachanh; Bountoy Sibounheuang; Anisone Chanthongthip; Manivone Simmalavong; Davanh Sengdatka; Amphaivanh Seubsanith; Valy Keoluangkot; Prasith Phimmasone; Kongkham Sisout; Khamsai Detleuxay; Khonesavanh Luangxay; Inpanh Phouangsouvanh; Scott B. Craig; Suhella M. Tulsiani; Mary Anne Burns; David A.B. Dance; Stuart D. Blacksell; Xavier de Lamballerie; Paul N. Newton; Aix Marseille Université; London School of Hygiene & Tropical Medicine; University of Oxford; Mahidol University; Queensland Health; Institute of Research and Education Development; Mahosot Hospital
    © 2019, Centers for Disease Control and Prevention (CDC). All Rights Reserved. During 2003–2011, we recruited 1,065 patients of all ages admitted to Mahosot Hospital (Vientiane, Laos) with suspected central nervous system (CNS) infection. Etiologies were laboratory confirmed for 42.3% of patients, who mostly had infections with emerging pathogens: viruses in 16.2% (mainly Japanese encephalitis virus [8.8%]); bacteria in 16.4% (including Orientia tsutsugamushi [2.9%], Leptospira spp. [2.3%], and Rickettsia spp. [2.3%]); and Cryptococcus spp. fungi in 6.6%. We observed no significant differences in distribution of clinical encephalitis and meningitis by bacterial or viral etiology. However, patients with bacterial CNS infection were more likely to have a history of diabetes than others. Death (26.3%) was associated with low Glasgow Coma Scale score, and the mortality rate was higher for patients with bacterial than viral infections. No clinical or laboratory variables could guide antibiotic selection. We conclude that high-dependency units and first-line treatment with ceftriaxone and doxycycline for suspected CNS infections could improve patient survival in Laos.