Publication: Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin M antibodies in Laos
Issued Date
2006-10-01
Resource Type
ISSN
15566811
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2-s2.0-33750334679
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Vaccine Immunology. Vol.13, No.10 (2006), 1166-1169
Suggested Citation
Stuart D. Blacksell, Lee Smythe, Rattanaphone Phetsouvanh, Michael Dohnt, Rudy Hartskeerl, Meegan Symonds, Andrew Slack, Manivanh Vongsouvath, Viengmone Davong, Olay Lattana, Simmaly Phongmany, Valy Keolouangkot, Nicholas J. White, Nicholas P.J. Day, Paul N. Newton Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin M antibodies in Laos. Clinical and Vaccine Immunology. Vol.13, No.10 (2006), 1166-1169. doi:10.1128/CVI.00219-06 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22973
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Title
Limited diagnostic capacities of two commercial assays for the detection of Leptospira immunoglobulin M antibodies in Laos
Abstract
The diagnostic utility of immunochromatographic (Leptotek) and enzyme-linked immunosorbent assay (ELISA; Panbio) tests for the detection of Leptospira immunoglobulin M antibodies was assessed in febrile adults admitted in Vientiane, Laos. Both tests demonstrated poor diagnostic accuracy using admission serum (Leptotek sensitivity of 47.3% and specificity of 75.5%: ELISA sensitivity of 60.9% and specificity of 65.6%) compared to the Leptospira "gold standard" microscopic agglutination test. Copyright © 2006, American Society for Microbiology. All Rights Reserved.