Browsing by Author "Patcharanee Pavadhgul"
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Publication Metadata only Camellia Oil-Enriched Diet Attenuates Oxidative Stress and Inflammatory Markers in Hypercholesterolemic Subjects(2016-09-01) Akkarach Bumrungpert; Patcharanee Pavadhgul; Ruchaneekorn W. Kalpravidh; Mahidol University; Faculty of Medicine, Siriraj Hospital, Mahidol University© Copyright 2016, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2016. Camellia oil is commonly used as an adjuvant in medicine. It is rich in monounsaturated fatty acids, vitamin E, and phytochemicals. The objective of this study was to examine effects of camellia oil consumption on oxidative stress, low-density lipoprotein-cholesterol (LDL-C) oxidation, and inflammatory markers in hypercholesterolemic subjects. The study design was a randomized, single-blind controlled trial. Women with hypercholesterolemia (n = 50) were randomly divided into two groups. The treatment group (n = 25) was provided camellia oil-enriched diets and the control group (n = 25) was provided diets cooked with soybean oil three meals (45 mL oil) a day for 8 weeks. Biomarkers of oxidative stress and inflammatory cytokines were assessed before and the after intervention. Camellia oil consumption significantly decreased malondialdehyde (11.2%; P < .001) whereas glutathione was not changed (P = .382). Moreover, the camellia oil group exhibited a statistically significant decrease in oxidized LDL-C (8.7%; P < .001) compared with the control group. Furthermore, camellia oil consumption significantly decreased high-sensitivity C-reactive protein (12.3%; P < .001) whereas tumor necrosis factor-α and interleukin-6 were not different (P = .079; P = .660, respectively) compared with the control group. These data indicate that the consumption of camellia oil-enriched diet could decrease oxidative stress and inflammatory markers in hypercholesterolemic women. Therefore, camellia oil consumption may reduce cardiovascular disease risk factors.Publication Open Access Consumption of Palm Date Herbal Beverage: Effect on Maternal and Infant Nutritional Status(2021) Chanadda Tanasinpiboon; Patcharanee Pavadhgul; Akkarach Bumrungpert; Mahidol University. Faculty of Public Health. Department of Nutrition; Dhurakij Pundit University. College of Integrative Medicine. Anti-Aging and Regenerative MedicineThis research aimed to examine the effect of a palm date beverage containing herbal beads on maternal and infant nutritional status. A randomized placebo-controlled trial was conducted in exclusively breastfed infants (aged one to six months) and their mothers. 47 mother-infant pairs who were randomly allocated to the experimental (n = 24) and placebo (n = 23) groups completed the study. The mothers in the experimental group consumed palm date beverage containing herbal beads consisting of banana flower, lemon basil, and Thai basil (65 ml/bottle), two bottles/day, for four weeks and the other group consumed a placebo drink. Maternal and infant nutritional status was measured before and after the intervention using a body composition analyzer and digital baby scale, respectively. Maternal nutritional status, determined by weight, percent body fat, body fat mass, body muscle mass, visceral fat rating and BMI, was not significantly different between the experimental and placebo groups. Moreover, for infant nutritional status, weight-for-age percentile was not significantly different in both groups. In conclusion, a palm date beverage that contained herbal beads had no effect on maternal and infant nutritional status. The study period should be extended and we recommend that a future study investigates infant weight in the early postnatal period (infant age less than one month).Publication Metadata only Dietary sodium intake by semi-quantitative food frequency questionnaire among undergraduate students of Mahidol University.(2009-12-01) Patcharanee Pavadhgul; Supawadee Sunthonwaraluk; Suwat Srisorachatr; Paradee Temcharoen; Mahidol UniversityTo assess sodium intake and identify its sources among undergraduate students aged 17 to 20 years who lived in the dormitory of Mahidol University, Salaya Campus. A cross sectional study was conducted among 170 students in July 2007. Data were collected using a semi-quantitative food frequency questionnaire. The mean total daily sodium intake was 5,225.0 +/- 2,228.9 mg for males and 4,497.9 +/- 2,091.2 mg for females. Male students consumed significantly higher sodium than females (p = 0.030). Daily sodium intake mainly came from one plate meals in the campus cafeteria which the average was 2,852.3 +/- 1,421.8 mg/day in males and 2,042.3 +/- 1,214.2 mg/day in females. Males consumed significantly higher sodium from one plate meals than females (p < 0.001). In addition, the average sodium intake from seasoning added during consumption was 539.8 +/- 498.8 mg/day in males and 473.3 +/- 514.5 mg/day in females. Dietary sodium intake among students was 2-fold higher than recommended amount (2,400 mg per day). The findings revealed that the undergraduate students who mainly consumed one plate meals are at risk of high sodium intake. Nutrition promotion for reducing sodium consumption in students and food vendors is needed for early prevention of chronic diseases in later life.Item Metadata only Effect of malva nut gum consumption on lipid profiles of postmenopausal obese women(Mahidol University. Mahidol University Library and Knowledge Center, 2010) Veeraya Sotiprawat; Patcharanee Pavadhgul; Santha Srisuparp; Promluck SomboonpanyakulItem Metadata only Effect of tomato juice consumption on lipid profiles(Mahidol University. Mahidol University Library and Knowledge Center, 2010) Sucharat Watcharasiribunlue; Patcharanee Pavadhgul; Kamol Udol ths; Dusit SujiraratPublication Metadata only The Effects of Date Fruit Consumption on Breast Milk Quantity and Nutritional Status of Infants(2021-11-01) Thanawan Modepeng; Patcharanee Pavadhgul; Akkarach Bumrungpert; Wirin Kitipichai; Mahidol University; Dhurakij Pundit UniversityBackground: Date fruit is a popular natural galactagogue among breastfeeding Muslim mothers. However, there is no evidence to support the effectiveness of date fruit in increasing the quantity of breast milk. Objective: This research aimed to study the effect of date fruit consumption on breast milk quantity and nutritional status of infants. Materials and Methods: This was a parallel randomized controlled trial. Forty-eight pairs of breastfeeding mothers and infants aged 1-3 months were included. The intervention group (n = 25) was asked to consume their normal dietary intake with 10 date fruits/day for 4 weeks. The control group (n = 23) was asked to consume their normal dietary intake without date fruit. Breast milk quantity was measured by using an electric breast pump and recorded for 2 days at baseline, week 2 and 4. The nutritional status of infants was assessed by calculating infant weight-for-age at baseline and week 4. Dietary data were collected at baseline, week 2, and 4, using a 2-day food record. Data were analyzed using Chi-square, t-test Mann-Whitney U test, and Wilcoxon matched-pairs signed-ranks test by SPSS version 18.0. Results: Breastfeeding mothers who received 10 date fruits/day had an 11% increase in breast milk quantity from baseline to week 2, and a 23% increase from baseline to week 4, (both p < 0.05). The breast milk quantity of the breastfeeding mothers who received date fruits was significantly higher than that of the control group (p < 0.05). However, there were no differences in infant nutritional status. Conclusions: Date fruit consumption appears to be useful for promoting and increasing breast milk quantity in breastfeeding mothers. Date fruits may be an alternative galactagogue.Publication Metadata only Effects of fenugreek, ginger, and turmeric supplementation on human milk volume and nutrient content in breastfeeding mothers: A randomized double-blind controlled trial(2018-12-01) Akkarach Bumrungpert; Promluck Somboonpanyakul; Patcharanee Pavadhgul; Siriporn Thaninthranon; Lerdsin Hospital; Mahidol University© 2018 Mary Ann Liebert, Inc., publishers. Background: Exclusive breastfeeding is the best way to accomplish optimal growth and health in infants. Low milk volume is a major problem that leads to nonexclusive breastfeeding. Objective: This study aimed to examine the effects of mixed herbal supplementation, including fenugreek, ginger, and turmeric on human milk volume and nutrient content. Methods: The study design was a randomized double-blind controlled trial. Fifty exclusively breastfeeding mothers were randomly divided into two groups. The herbal group (n = 25) received mixed herbal supplementation containing fenugreek, ginger, and turmeric, three capsules three times daily for 4 weeks. The control group (n = 25) took a placebo. Anthropometric and dietary data, blood pressure, heart rate, and blood and milk samples were collected at baseline and 4 weeks after the intervention. Milk volume was measured using a manual breast pump and recorded for 2 days at baseline, week 2, and week 4. Results: Breastfeeding mothers receiving herbal supplementation had a 49% increase in milk volume at week 2 and a 103% increase at week 4. These increases were greater than mothers in the placebo group (p < 0.05). There was no difference in milk nutrient content for both groups. Moreover, there were no differences in adverse effects observed in the placebo and herbal groups. Conclusion: Mixed herbal supplementation that contained fenugreek, ginger, and turmeric can increase human milk volume without adverse effects.Publication Metadata only Efficacy of dietary modification following the National Cholesterol Education Program (NCEP) recommendation on lipid profiles among hyperlipidemia subjects.(2013-10-01) Suruchsawadee Thiengwiboonwong; Rewadee Chongsuwat; Paradee Temcharoen; Wongdyan Pandii; Patcharanee Pavadhgul; Mahidol UniversityHyperlipidemia has adverse effects on atherosclerosis, causing it to develop into cardiovascular disease. The prevalence of hyperlipidemia has been increasing among those in the working-age group and may be caused by inappropriate dietary patterns. Dietary modification should form the basis of lipid management. Evaluate the effects of a dietary modification following the NCEP-ATP III recommendation on lipid profiles among hyperlipidemia subjects. The design was a quasi-experimental study, with a pre-test/post-test two-group design. Each group consisted of 31 hyperlipidemia subjects aged 30 to 59 years old with total cholesterol (TC) greater than or equal to 240 mg/dl or low-density lipoprotein cholesterol (LDL-C) greater than or equal to 130 mg/dl. The present study was conducted between January and June 2009. The research procedure included 6-week nutrition counseling and a 2-week follow-up for 12 weeks. Data were collected by self-reported questionnaire and a 3-day food record. Dietary and biological assessments were compared before and after the experiment. Statistical analysis was performed using means, standard deviations, independent and paired t-tests, Friedman test, Mann-Whitney U test, and Wilcoxon signed-rank test. The intervention group had a significant reduction of TC and LDL-C at the end of the experiment (p < 0.05). Moreover this group had a significantly higher percentage reduction of TC and LDL-C than the control group (8.5% vs. 3.0%, and 10.8% vs. 2.4%, respectively) (p < 0.05). Distributions of monounsaturated fatty acids (MUFAs) in the intervention group were significantly higher than in the control group (p < 0.05). Distribution of saturated fatty acids (SFAs):MUFAs:polyunsaturated fatty acids (PUFAs) were 12.0:13.4:6.3% in the intervention group and 12.3:9.2:5.6% in the control group. Neither group was able to reduce SFAs intake to < 7% as recommended. Neither the recommended one-third of vegetable protein nor two-thirds of complex carbohydrate was achieved Dietary fiber was less than 10 g/1,000 kcal. The cholesterol intake in the intervention group was less than in the control group (155.9 vs. 206.3 mg/d). The dietary modification in the present study significantly lowered TC and LDL-C. However compliance with the recommendation of high MUFAs intake was difficult to achieve. The dietary modification might be focused instead on lowering intake of SFAs, replacing animal protein with vegetable protein, and increasing complex carbohydrates, fruits, and vegetables to raise dietary fiber.Publication Metadata only Evaluation of a questionnaire to assess nutritional knowledge, attitudes and practices in a Thai population(2019-07-10) Rungnapa Pongkiatchai; Rewadee Chongsuwat; Nopporn Howteerakul; Patcharanee Pavadhgul; William Ollier; Artitaya Lophatananon; Mahidol University; University of Manchester© 2019 The Author(s). Background: The rapid increase in non-communicable chronic diseases in people of working age has had a major effect on health care utilization, productivity and economy. Lifestyle and diet are recognized as being major risk determinants involved. Disease prevention strategies need to be based on people's understanding of nutritional knowledge, attitudes and practice. This study evaluates the validity of a new nutritional knowledge and practice questionnaire specifically developed for assessing individuals of working age in a Thai population. Methods: The questionnaire was constructed and based on previous relevant literature and its content validity was scrutinized by an expert panel. An exploratory factor analysis (EFA) was performed to reduce the number of questions included. Subsequently, data from a cross-sectional study of 1,032 participants were used to evaluate the reliability and validity of this questionnaire. The validity of the questionnaire constructed for assessing knowledge and attitude was evaluated using Confirmatory Factor Analysis (CFA). For the practice component, set criteria were applied to determine the final variables used. Results: CFA of the nutritional knowledge component suggested that all the variables in the model fitted with the data (χ 2 = 80.17, df = 66, p > 0.05, CFI = 0.99, RMSEA = 0.01, SRMR = 0.02). The CFA final model for the nutritional knowledge included three factors (food recommendation, nutrients related to diseases, and healthy diet) with a total of 14 questions. For nutrition attitude, CFA also revealed a good fit (χ 2 = 178.14, df = 93, p < 0.001, CFI = 0.99, RMSEA = 0.03, SRMR = 0.03). The final CFA model for nutritional attitude included three factors (food choice, healthy diet and food recommendation) with a total of 16 questions. For practice items, the number of questions was reduced from 76 to 60. Conclusions: Questionnaire development should use a logical, systematic and structured approach. Results from our evaluation process demonstrates the construction validity of the nutritional knowledge and practice questionnaire developed. This questionnaire can be further modified for use in other countries within the region.Publication Metadata only Maternal return to paid work and breastfeeding practices in Bangkok, Thailand(2015-01-01) Tomomi Aikawa; Patcharanee Pavadhgul; Rewadee Chongsuwat; Siraporn Sawasdivorn; Chaweewon Boonshuyar; Japan International Cooperation Agency; Mahidol University; Queen Sirikit National Institute of Child Health© 2011 APJPH. This study explored the association between mothers' work-related factors and breastfeeding practices in Bangkok, Thailand. Data were collected from 84 working mothers with a child aged 6 to 24 months who visited the breastfeeding mobile clinic at a nursery goods exhibition. Thai interviewers collected data using a structured questionnaire. Analysis of the data showed that exclusive breastfeeding for 3 months was 78.6%, and for 6 months it was 38.1%. Mothers who returned to work 3 months or more after giving birth exclusively breastfed more than the mothers who returned to work in less than 3 months (crude odds ratio [OR] = 4.26, 95% confidence interval [CI] = 1.39-13.05; adjusted OR = 4.15, 95% CI = 1.15-14.95). Moreover, mothers who worked at self-employed or family-owned businesses and some mothers working at private companies showed tendencies of returning to work in less than 3 months. Results suggest that longer maternity leave would help extend the duration of exclusive breastfeeding. In addition, the improvement of a breastfeeding supportive environment in the workplace would be valuable and may be an effective means to improve breastfeeding practices and infant health.Item Metadata only Method development for determination of ferulic acid and gamma-oryzanol in rice bran(Mahidol University. Mahidol University Library and Knowledge Center, 2010) Chaluntorn Sawetavong; Supathra Lilitchan; Kornkanok Aryusuk; Patcharanee PavadhgulPublication Metadata only Nutraceutical Improves Glycemic Control, Insulin Sensitivity, and Oxidative Stress in Hyperglycemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial(2020-01-01) Akkarach Bumrungpert; Patcharanee Pavadhgul; Rewadee Chongsuwat; Surat Komindr; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol University; Dhurakij Pundit University© The Author(s) 2020. The aim of this research was to investigate the effects of nutraceuticals including bitter melon, fenugreek, cinnamon, alpha-lipoic acid, zinc, biotin, chromium, and cholecalciferol on glycemic control, insulin sensitivity, lipid profiles, oxidative stress, and inflammatory markers in hyperglycemia. The study design was a randomized, double-blind, placebo-controlled trial. Subjects with hyperglycemia were randomly divided into 2 groups. The treatment group (n = 52) was given a nutraceutical and the control group (n = 50) was provided with a placebo for 12 weeks. Fasting blood glucose (FBG), hemoglobin A1c (HbA1C), homeostatic model assessment of insulin resistance (HOMA-IR), lipid profiles, biomarkers of oxidative stress, and inflammation were assessed before and after the intervention at 6 weeks and 12 weeks. Nutraceutical supplementation demonstrated a statistically significant decrease in FBG (13.4% and 18.9%), HbA1C (6.5% and 11.3%), and HOMA-IR (28.9% and 35.2%) compared with the placebo. Moreover, low-density lipoprotein-cholesterol (LDL-C) level was significantly reduced in the nutraceutical group (7.1% and 9.3%). Furthermore, the nutraceutical significantly decreased oxidative stress markers, oxidized LDL-C (14.8% and 18.9%) and malondialdehyde (16.6% and 26.2%) compared with the placebo. In conclusion, this nutraceutical can improve glycemic control, insulin resistance, lipid profiles, and oxidative stress markers in hyperglycemic subjects. Therefore, it has the potential to decrease cardiovascular disease risk factors. Clinical trial registration: TCTR20180907001, www.clinicaltrials.in.th.Item Metadata only Nutrition curriculum for voluntary counseling testing counselors in Can Tho city, Vietnam(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Le Ngoc Cua; Suwat Srisorrachatr; Jeeranun Klaewkla; Patcharanee PavadhgulThis study was designed to develop the outcomes-based nutrition curriculum, monitor and evaluate the implementation of the nutrition curriculum. All of the VCT counselors (37 staff) and 272 HIV-clients were chosen by systematic random sampling from 10 VCT sites in Can Tho city, Vietnam and participated in the research. Outcomes-based education (OBE) with the concept "Aligning education within the local context" which was used to design the nutrition curriculum. The process of research consisted of three stages: (1) the situation analysis included the analysis of the components of local contexts such as HIV/AIDS related policies, HIV-client's needs for nutritional care and support, nutritional counseling-related demands of VCT site, tasks, and existing the nutritional competency of VCT counselors. The task analysis of nutritional counseling elicited expected main competencies for VCT counselors. Matching each one with components of local context led to the determination of counselors' learning needs. (2) From those, the development of curriculum content, learning activities and assessment criteria for each module were done. (3) The curriculum was evaluated and refined through obtaining feedback from reviewers. The monitoring of the implementation of the curriculum measured the satisfaction of learners, and difficulty level of curriculum content etc. The Quasi experimental study with the "One-Group, Pre-test, and Post-test Design" was applied to evaluate the competency of VCT counsellors and HIV-client's knowledge, attitude, and practice about nutrition. Data analysis by the inferential statistics paired-t-test was applied. There was the significant matched pair increase in competency between before and after OBE among VCT counsellors and the improvement of KAP of HIV-infected clients about nutrition after two months. OB nutrition curriculum could improve local health staff's competency in order to integrate effectively nutritional counseling in VCT sites. The adaptability of OB nutrition curriculum to local context made learners satisfied and local health leaders felt it feasible.Publication Metadata only Oat porridge consumption alleviates markers of inflammation and oxidative stress in hypercholesterolemic adults(2019-01-01) Patcharanee Pavadhgul; Akkarach Bumrungpert; Yashna Harjani; Anne Kurilich; PepsiCo, Inc.; Mahidol UniversityBACKGROUND AND OBJECTIVES: Oats contain antioxidant phytochemicals that may help reduce inflammation as well as oxidative stress. In this study we aimed to investigate the effect of oat porridge consumption on inflammatory marker levels and oxidative stress in Thai adults with high blood lipid levels. METHODS AND STUDY DESIGN: A randomized crossover study was conducted. Hypercholesterolemic adults were randomly assigned to a 4-week daily consumption of oat or rice porridge. After 4 weeks, they were switched to alternate intervention arms for 4 weeks. At baseline, before and after each intervention period, inflammatory markers including hsCRP, IL-6, IL-8, TNF-α, and MCP-1 and antioxidant status markers including ORAC, FRAP, and MDA of all subjects were measured. RESULTS: Compared to baseline, levels of hsCRP, IL-6, IL-8, and TNF-α were significantly decreased after oat porridge consumption (mean change: -0.6±0.9 mg/L, -26.9±27.6 pg/mL, -56.3±27.6 pg/mL, and - 9.7±11.6 pg/mL, p<0.05 for all, respectively). In addition, consumption of oat porridge also increased antioxidant capacity; ORAC and FRAP levels (mean change: 2.7±1.0 μmol of Trolox/L and 2.4±0.8 μmol of Fe2+/L, p<0.001, respectively). However, MCP-1 and MDA levels were not affected. Consumption of rice porridge did not lead to significant changes in these measures. CONCLUSIONS: Daily consumption of 70 grams oat porridge containing 3 grams β-glucan for 4 weeks may help reduce markers of inflammation and oxidation in hypercholesterolemic adults. Therefore, oat may be an appropriate dietary recommendation for individuals with hypercholesterolemia.Publication Metadata only Participatory action project in reducing childhood obesity in Thai primary schools(2011-11-01) Chutima Sirikulchayanonta; Patcharanee Pavadhgul; Rewadee Chongsuwat; Jeeranun Klaewkla; Mahidol UniversityThe project aimed to improve nutrition and activity among primary schoolchildren via targeted activities. A preliminary nutritional survey was carried out involving 5126 children in 4 Bangkok public schools. Participatory action research involving students, teachers, and parents was conducted. After a 2-day training course, teachers integrated project concepts into their course curriculum. Seminars on weight management were given separately to parents and students. After 8 months, postnutritional survey was conducted. Preprogram and postprogram evaluation of obese and normal groups was done using questionnaires on dietary intake and exercise. Results showed that high caloric dietary intake significantly decreased for the obese group (P < .001). Aerobic exercise activity also increased in both groups (P < .001) and prevalence of obesity declined from 19.3% to 16.8%. Thus, a long-term, participatory effort to promote healthy diets and physical exercise could be effective with primary school students and may establish habits that last to later life. © 2011 Asia-Pacific Academic Consortium for Public Health.Item Open Access Sodium content trend and characteristics of instant foods sold in Thailand, 2018-2021(Mahidol University, 2022) Chanatip Chailek; Patcharanee Pavadhgul; Wirin Kittipichai; Surasak KantachuvesiriInstant foods are high-sodium products that people consume. Thailand has implemented a national strategy to reduce sodium consumption. This analytic study aimed to describe the sodium content trends in instant foods sold in Thailand by food characteristics using secondary data from the Food and Drug Administration and the Low Salt Network. Data were collected using a data extraction form. Descriptive statistics, the Mann-Whitney U test, Kruskal-Wallis’s test, Wilcoxon singed-rank test, and Chi-square test were used in data analysis with a level of statistical significance of less than 0.05.The results from 788 records revealed that the median sodium content of instant foods in2021 was 1,750.0 mg/100 g (interquartile range 1,289.1–2,267.3), which was decreased by 11.6 to 2018 (p-value = 0.019). Rice porridge/rice soup, brand C, egg noodles type, containing in a cup, and manufacturers in Thailand and China were food characteristics that had a decreasing trend. The median sodium level in the same products between 2018 and 2021 was not changed (p-value = 0.056).Nineteen (33.3%) products were decreased in sodium levels. The proportion of healthier items increased from 4.5% to 21.1% in 2018 and 2021 (p-value <0.001), including noodles and rice porridge/rice soup and products made in Thailand. Implication of the Thematic Paper: Consumers could apply the findings as an initial guideline for choosing healthy foods. Nonetheless, they still had to check the nutrition labels before purchasing. The relevant authorities should revise the Healthier Choice criteria for instant foods, set the sodium content target of instant foods disaggregated by characteristics using the sodium content in 2021 as the baseline and systematically monitor the food reformulation of the food industry.Item Metadata only The estimation of sodium intake by semi quantitative food frequency questionnaire among undergraduate students of Mahidol University(Mahidol University. Mahidol University Library and Knowledge Center, 2008) Supawadee Sunthonwaraluk; Patcharanee PavadhgulItem Metadata only The quantity of specific nutrients related to cardiovascular disease in popular Thai ready to eat food products(Mahidol University. Mahidol University Library and Knowledge Center, 2006) Poonsak Boonyoung; Patcharanee PavadhgulPublication Metadata only Whey Protein Supplementation Improves Nutritional Status, Glutathione Levels, and Immune Function in Cancer Patients: A Randomized, Double-Blind Controlled Trial(2018-06-01) Akkarach Bumrungpert; Patcharanee Pavadhgul; Pornpimon Nunthanawanich; Anchalee Sirikanchanarod; Araya Adulbhan; National Cancer Institute Thailand; Mahidol University© Copyright 2018, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2018. Clinical side effects from medical therapy play an important role in causing malnutrition among cancer patients. Whey protein isolates (WPIs) have the potential to improve the nutritional status of cancer patients. The present study determined the effects of whey protein supplementation on nutritional status, glutathione (GSH) levels, immunity, and inflammatory markers in cancer patients in Thailand. A total of 42 cancer patients (41-63 years old) who received intravenous chemotherapy were randomized in a double-blind controlled trial at the National Cancer Institute in Thailand. Patients received 40 g of WPI plus zinc and selenium (intervention group, n = 23) or a maltodextrin oral snack (control group, n = 19) every day during the daytime for 12 weeks. Nutritional status, GSH levels, immunity, and inflammatory markers were assessed at baseline, 6, and 12 weeks. Whey protein supplementation significantly increased albumin (2.9%) and immunoglobulin G (4.8%) levels compared to the control group at week 12. Controls showed a significantly lower percent change in GSH levels (6.0%), whereas there was a significant time-dependent increase in the intervention group (11.7%). Whey protein supplementation improved nutrition status scores in the intervention group compared to the control. These data indicate that whey protein supplementation can increase GSH levels and improve nutritional status and immunity in cancer patients undergoing chemotherapy. These results will facilitate implementation of malnutrition risk prevention strategies and improve protein status, including immune function, during chemotherapy.Publication Open Access การส่งเสริมการบริโภคผักและผลไม้โดยประยุกต์ทฤษฎีการเรียนรู้ทางปัญญาสังคมในนักเรียนชั้นประถมศึกษาปีที่ 4 อำเภอพรหมพิราม จังหวัดพิษณุโลก(2556) วราภรณ์ ยังเอี่ยม; พัชราณี ภวัตกุล; มันทนา ประทีปะเสน; นิรัตน์ อิมามี; Patcharanee Pavadhgul; Mandhana Pradipasen; Nirat Imamee; พัชราณี ภวัตกุล; มหาวิทยาลัยมหิดล. คณะสาธารณสุขศาสตร์. ภาควิชาโภชนวิทยา; มหาวิทยาลัยมหิดล. คณะสาธารณสุขศาสตร์. ภาควิชาสุขศึกษาและพฤติกรรมศาสตร์ผักและผลไม้เป็นอาหารที่เป็นปัจจัยปกป้องและชะลอการเกิดโรคเรื้อรัง แต่ยังพบว่า มีการบริโภคผักและผลไม้ต่ำกว่าปริมาณที่แนะนำในเกือบทุกกลุ่มอายุโดยเฉพาะเด็กวัยเรียน การวิจัยกึ่งทดลองนี้ มีวัตถุประสงค์เพื่อศึกษาประสิทธิผลของการส่งเสริมการบริโภคผักและผลไม้ โดยประยุกต์ทฤษฎีการเรียนรู้ทางปัญญาสังคม กลุ่มตัวอย่างเป็นนักเรียนชั้นประถมศึกษาปีที่ 4 จำนวน 64 คน จาก 2 โรงเรียน ในอำเภอพรหมพิราม จังหวัดพิษณุโลก โดยการสุ่มอย่างง่ายได้ 1 โรงเรียนเป็นกลุ่มทดลอง มีนักเรียนจำนวน 34 คน และอีก 1 โรงเรียนเป็นกลุ่มเปรียบเทียบมีนักเรียนจำนวน 30 คน ระยะเวลาศึกษา 12 สัปดาห์ระหว่างเดือนสิงหาคมถึงพฤศจิกายน 2555 ประกอบด้วย ระยะทดลอง 8 สัปดาห์ และระยะติดตามผล 4 สัปดาห์ รวบรวมข้อมูลโดยใช้แบบสอบถามแบบตอบด้วยตนเอง และแบบบันทึกการบริโภคผักและผลไม้ วิเคราะห์ทางสถิติโดยใช้ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน และการวัดซ้ำ ผลการวิจัย พบว่า หลังการทดลอง กลุ่มทดลองมีคะแนนเฉลี่ยความรู้ การรับรู้ความสามารถของตนเอง ความคาดหวังในผลดี และมีปริมาณเฉลี่ยการบริโภคผักและผลไม้สูงขึ้นกว่าก่อนการทดลอง และมากกว่ากลุ่มเปรียบเทียบอย่างมีนัยสำคัญทางสถิติ (p<0.05) การวิจัยนี้ชี้ให้เห็นว่าการส่งเสริมการบริโภคผักและผลไม้โดยประยุกต์ทฤษฎีการเรียนรู้ทางปัญญาสังคม มีส่วนช่วยเพิ่มความรู้การรับรู้ความสามารถของตนเอง ความคาดหวังในผลดีและทำให้นักเรียนบริโภคผักและผลไม้เพิ่มขึ้น ดังนั้นโรงเรียนควรนำกิจกรรมไปประยุกต์ใช้ เพื่อเป็นการสร้างเสริมพฤติกรรมสุขภาพที่ดีและยั่งยืน Eating fruits and vegetables is one of the protective factors for prevention of chronic diseases. However, there is low consumption of fruits and vegetables in all age groups in Thailand, especially among school age children. The purpose of this quasi-experimental study was to evaluate the effectiveness of promoting fruit and vegetable intake through the application of social cognitive theory. The sample consisted of 64 students in 4th grade in 2 schools in Phrompiram District, Phitsanulok Province. Participanting schools were assigned at random to an experiment group (n=34) or a comparison group (n=30). A 12-week study period, during August to November 2012 included an 8-week experimental and a 4-week follow-up period. Data were collected by self-administered questionnaires and a fruit and vegetable record. Statistical analysis was performed using mean, standard deviation and repeated measures. Results indicated that after the intervention the experimental group had signifi cantly higher mean scores of knowledge, self-effi cacy, and outcome expectation, and consumed fruit and vegetables more than before the intervention in contrast to the comparison group (p<0.05). Activities promoting fruit and vegetable intake through the application of social cognitive theory increased knowledge, self-effi cacy, outcome expectation and increased consumption of fruits and vegetables. Therefore, schools should adopt these activities to promote healthy, sustainable eating behaviors .