Browsing by Author "Phoutthasone Sibounnavong"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • No Thumbnail Available
    PublicationMetadata only
    Triterpene lactones from cultures of Ganoderma sp. KM01
    (2014-07-25) Waranya Lakornwong; Kwanjai Kanokmedhakul; Somdej Kanokmedhakul; Palangpon Kongsaeree; Samran Prabpai; Phoutthasone Sibounnavong; Kasem Soytong; Khon Kaen University; Mahidol University; National University of Laos; King Mongkut's Institute of Technology Ladkrabang
    A revised structure of colossolactone G (1), seven new triterpene lactones, ganodermalactones A-G (2-8), and five known triterpene lactones, colossolactone I (9), schisanlactone B (10), colossolactone B (11), colossolactone E (12), and colossolactone IV (13), and ergosterol have been isolated from cultured biomass of the macrofungi Ganoderma sp. KM01. Their structures were identified by spectroscopic methods. Structures and relative configurations of 3, 7, and 8 were confirmed by X-ray crystallographic analysis. Compounds 7, 10, and 12 exhibited antimalarial activity against Plasmodium falciparum in the range 6.0-10.0 μM (IC50). © 2014 The American Chemical Society and American Society of Pharmacognosy.