Publication: Triterpene lactones from cultures of Ganoderma sp. KM01
Issued Date
2014-07-25
Resource Type
ISSN
15206025
01633864
01633864
Other identifier(s)
2-s2.0-84905046022
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.77, No.7 (2014), 1545-1553
Suggested Citation
Waranya Lakornwong, Kwanjai Kanokmedhakul, Somdej Kanokmedhakul, Palangpon Kongsaeree, Samran Prabpai, Phoutthasone Sibounnavong, Kasem Soytong Triterpene lactones from cultures of Ganoderma sp. KM01. Journal of Natural Products. Vol.77, No.7 (2014), 1545-1553. doi:10.1021/np400846k Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33239
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Title
Triterpene lactones from cultures of Ganoderma sp. KM01
Abstract
A revised structure of colossolactone G (1), seven new triterpene lactones, ganodermalactones A-G (2-8), and five known triterpene lactones, colossolactone I (9), schisanlactone B (10), colossolactone B (11), colossolactone E (12), and colossolactone IV (13), and ergosterol have been isolated from cultured biomass of the macrofungi Ganoderma sp. KM01. Their structures were identified by spectroscopic methods. Structures and relative configurations of 3, 7, and 8 were confirmed by X-ray crystallographic analysis. Compounds 7, 10, and 12 exhibited antimalarial activity against Plasmodium falciparum in the range 6.0-10.0 μM (IC50). © 2014 The American Chemical Society and American Society of Pharmacognosy.