Browsing by Author "S. Intahphuak"

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    Anti-inflammatory and analgesic activities of Mallotus spodocarpus Airy Shaw
    (2004-01-01) S. Intahphuak; A. Panthong; D. Kanjanapothi; T. Taesotikul; C. Krachangchaeng; V. Reutrakul; Chiang Mai University; Mahidol University
    The chloroform extract from the roots of Mallotus spodocarpus was investigated for anti-inflammatory and analgesic activities in animal models. In acute inflammatory models, the extract significantly inhibited ethyl phenylpropiolate-induced ear edema and carrageenin- and arachidonic acid-induced hind paw edema in rats. In the chronic inflammatory model using the cotton pellet-induced granuloma in rats, the extract exhibited inhibitory activity on the formation of granuloma. The extract also elicited pronounced inhibitory effect on acetic acid-induced writhing response in mice in the analgesic test. The results obtained suggest marked anti-inflammatory and analgesic activity of the extract. © 2003 Elsevier Ireland Ltd. All rights reserved.