Browsing by Author "Simon Collard"

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    Synthesis of 3-substituted isoindolin-1-ones via a palladium-catalysed 3-component carbonylation/amination/Michael addition process
    (2003-09-29) Xinjie Gai; Ronald Grigg; Tossapol Khamnaen; Shuleewan Rajviroongit; Visuvanathar Sridharan; Lixin Zhang; Simon Collard; Ann Keep; University of Leeds; Mahidol University; Johnson Matthey
    A novel palladium-catalysed three component cascade process is described involving carbonylation of an aryl iodide to generate an acyl palladium species which is intercepted by a primary aliphatic/aromatic amine, amide or sulfonamide followed by intramolecular Michael addition to afford 3-substituted isoindolin-1-ones in good yield. © 2003 Elsevier Ltd. All rights reserved.
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    Synthesis of N-substituted isoindolinones via a palladium catalysed three-component carbonylation - amination - Michael addition cascade
    (2005-06-01) Ronald Grigg; Xinjie Gai; Tossapol Khamnaen; Shuleewan Rajviroongit; Visuvanathar Sridharan; Lixin Zhang; Simon Collard; Ann Keep; University of Leeds; Mahidol University; Johnson Matthey Plc
    We herein describe a novel palladium catalysed three-component cascade process involving carbonylation of an aryl iodide to generate an acyl palladium(II) species that is intercepted by a primary aliphatic or aromatic amine, amide, or sulfonamide followed by intramolecular Michael addition to furnish N-substituted isoindolinones in good yield. Overall, the cascade results in the formation of one C-C and two C-N bonds, one ring and one stereocentre. © 2005 NRC Canada.