Publication:
Synthesis of 3-substituted isoindolin-1-ones via a palladium-catalysed 3-component carbonylation/amination/Michael addition process

Issued Date

2003-09-29

Resource Type

Article

ISSN

00404039

DOI

10.1016/j.tetlet.2003.08.036

Other identifier(s)

2-s2.0-0042836595

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Tetrahedron Letters. Vol.44, No.40 (2003), 7441-7443

Suggested Citation

Xinjie Gai, Ronald Grigg, Tossapol Khamnaen, Shuleewan Rajviroongit, Visuvanathar Sridharan, Lixin Zhang, Simon Collard, Ann Keep Synthesis of 3-substituted isoindolin-1-ones via a palladium-catalysed 3-component carbonylation/amination/Michael addition process. Tetrahedron Letters. Vol.44, No.40 (2003), 7441-7443. doi:10.1016/j.tetlet.2003.08.036 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20694

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Title

Synthesis of 3-substituted isoindolin-1-ones via a palladium-catalysed 3-component carbonylation/amination/Michael addition process

Author(s)

Xinjie Gai
 Ronald Grigg
 Tossapol Khamnaen
 Shuleewan Rajviroongit
 Visuvanathar Sridharan
 Lixin Zhang
 Simon Collard
 Ann Keep

Other Contributor(s)

University of Leeds
 Mahidol University
 Johnson Matthey

Abstract

A novel palladium-catalysed three component cascade process is described involving carbonylation of an aryl iodide to generate an acyl palladium species which is intercepted by a primary aliphatic/aromatic amine, amide or sulfonamide followed by intramolecular Michael addition to afford 3-substituted isoindolin-1-ones in good yield. © 2003 Elsevier Ltd. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/20694

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Scopus 2001-2005