Browsing by Author "T. Santisuk"

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    2-Substituted furans from Polyalthia suberosa
    (2001-09-11) P. Tuchinda; M. Pohmakotr; V. Reutrakul; W. Thanyachareon; S. Sophasan; C. Yoosook; T. Santisuk; J. M. Pezzuto; Mahidol University; Thailand Royal Forest Department; University of Illinois at Chicago
    Two new 2-substituted furans, 1-(2-furyl)pentacosa-16,18-diyne and 23-(2-furyl)tricosa-5,7-diynoic acid, have been isolated from stems of Polyalthia suberosa. The structures were assigned by spectroscopic methods. The two compounds together with the previously reported kalasinamide, N-trans-feruloyltyramine and N-trans-coumaroyltyramine showed anti-HIV activities.
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    Evaluation of anti-HSV-2 activities of Barleria lupulina and Clinacanthus nutans
    (1999-11-01) C. Yoosook; Y. Panpisutchai; S. Chaichana; T. Santisuk; V. Reutrakul; Mahidol University; Thailand Ministry of Agriculture and Cooperatives
    Barleria lupulina Lindl. and Clinacanthus nutans (Burm. f.) Lindau, both belonging to the family Acantaceae, are well-known medicinal plants used in Thai folklore medicine. Virucidal effects of organic extracts of these two plants against herpes simplex virus type 2 strain G, HSV-2 (G), the standard HSV-2 strain were noted. The extracts were assessed for intracellular activities against HSV-2 (G) and five clinical HSV-2 isolates. B. lupulina extract exhibited activity against all five isolates but not the standard strain while that of C. nutans did not show any activity against these viruses as determined by plaque inhibition assay. When the activities were verified by yield reduction assay, anti-HSV-2 activities of B. lupulina extract were observed against HSV-2 (G) as well. The results suggest a therapeutic potential of B. lupulina but not C. nutans against HSV-2. Copyright (C) 1999 Elsevier Science Ireland Ltd.
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    Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza
    (1993-11-02) P. Claeson; A. Panthong; P. Tuchinda; V. Reutrakul; D. Kanjanapothi; W. C. Taylor; T. Santisuk; Mahidol University
    Bioassay-guided fractionation of a hexane extract of the rhizomes of Curcuma xanthorrhiza Roxb. (Zingiberaceae) led to the isolation of three non-phenolic diarylheptanoids, identified mainly by high-field 1H-NMR as trans-trans-1,7-diphenyl-1,3-heptadien-4-one (alnustone), trans-1,7-diphenyl-1-hepten-5-ol, and trans,trans-1,7-diphenyl-1,3-heptadien-5-ol. The latter is reported for the first time as a plant constituent. Germacrone, curzerenone, and cinnamaldehyde were also isolated and identified. The three diarylheptanoids all exerted significant anti-inflammatory activity in the assay of carrageenin-induced hind paw edema in rats.