Publication: Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza
Issued Date
1993-11-02
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ISSN
00320943
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2-s2.0-0027519772
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.59, No.5 (1993), 451-454
Suggested Citation
P. Claeson, A. Panthong, P. Tuchinda, V. Reutrakul, D. Kanjanapothi, W. C. Taylor, T. Santisuk Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza. Planta Medica. Vol.59, No.5 (1993), 451-454. doi:10.1055/s-2006-959730 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22511
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Title
Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza
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Abstract
Bioassay-guided fractionation of a hexane extract of the rhizomes of Curcuma xanthorrhiza Roxb. (Zingiberaceae) led to the isolation of three non-phenolic diarylheptanoids, identified mainly by high-field 1H-NMR as trans-trans-1,7-diphenyl-1,3-heptadien-4-one (alnustone), trans-1,7-diphenyl-1-hepten-5-ol, and trans,trans-1,7-diphenyl-1,3-heptadien-5-ol. The latter is reported for the first time as a plant constituent. Germacrone, curzerenone, and cinnamaldehyde were also isolated and identified. The three diarylheptanoids all exerted significant anti-inflammatory activity in the assay of carrageenin-induced hind paw edema in rats.