Browsing by Author "Uma Kanga"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • No Thumbnail Available
    PublicationMetadata only
    Designing and implementing sample and data collection for an international genetics study: The Type 1 Diabetes Genetics Consortium (T1DGC)
    (2010-08-01) Joan E. Hilner; Letitia H. Perdue; Elizabeth G. Sides; June J. Pierce; Ana M. Wägner; Alan Aldrich; Amanda Loth; Lotte Albret; Lynne E. Wagenknecht; Concepcion Nierras; Beena Akolkar; Tracey Baskerville; Nines Bautista; Eesh Bhatia; Vijayalakshmi Bhatia; Kamaruzaman Bin Hasan; Francois Bonnici; Thomas Brodnicki; Brian Browning; Fergus Cameron; Katharee Chaichanwatanakul; Pik To Cheung; Peter Colman; Andrew Cotterill; Jenny Couper; Patricia Crock; Ric Cutfield; Tim Davis; Paul Dixon; Kim Donaghue; Katrina Dowling; Paul Drury; Sarah Dye; Shane Gellert; Rohana Abdul Ghani; Ristan Greer; Xueyao Han; Len Harrison; Nick Homatopoulos; Linong Ji; Tim Jones; Loke Kah Yin; Nor Azmi Kamaruddin; Uma Kanga; Alok Kanungo; Gurvinder Kaur; Betty Kek; Simon Knowles; Jeremy Krebs; Neeraj Kumar; Yann Jinn Lee; Xiaoying Li; Supawadee Liktimaskul; Margaret Lloyd; Amanda Loth; Anthony Louey; Narinder Mehra; Tony Merriman; Liu Min; Grant Morahan; Robert Moses; Grant Mraz; Rinki Murphy; Ian Nicholson; Araceli Panelo; Perlita Poh; Gareth Price; Nirubasini Ratnam; Carani Sanjeevi; Saikiran Sedimbi; Shuixian Shen; Goh Siok Ying; Brian Tait; Nikhil Tandon; Allison Thomas; Mike Varney; Praewvarin Weerakulwattana; Jinny Willis; Elvis Abang Akwo; Lotte Albret; Francisco Ampudia-Blasco; Jesus Argente; Magdalena Avbelj; Gulja Babadjanova; Klaus Badenhoop; Tadej Battelino; Georg Beilhack; Regine Bergholdt; Polly Bingley; Bernhard Boehm; Jo Bolidson; Kerstin Brismar; Caroline Brorsson; Joyce Carlson; Luis Castano; Kyla Chandler; Valentino Cherubini; Ondrej Cinek; University of Alabama at Birmingham; Wake Forest University Health Sciences; Hagedorn Research Institute; Hospital Insular, Las Palmas; Universidad de Las Palmas de Gran Canaria; University of Alaska Anchorage; Walter and Eliza Hall Institute of Medical Research; Juvenile Diabetes Research Foundation International; National Institute of Diabetes and Digestive and Kidney Diseases; Mater Hospital; Institute for Study on Diabetes Foundation; Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow; National University of Malaysia Hospital; University of Cape Town; University of Auckland; Royal Children's Hospital, Melbourne; Mahidol University; Queen Mary Hospital Hong Kong; Women’s and Children’s Hospital; John Hunter Children’s Hospital; North Shore Hospital; Fremantle Hospital and Health Service; Diabetes Lifestyle Centre; Children's Hospital At Westmead; Australian Red Cross Blood Service; Auckland Diabetes Centre; Western Australia Institute for Medical Research; Royal Melbourne Hospital; University of Queensland; Peking University; Princess Margaret Hospital for Children; Children's Medical Institute; All India Institute of Medical Sciences, New Delhi; Cuttack Diabetes Research Foundation; Diabetes Centre; Mackay Memorial Hospital Taiwan; Shanghai Jiao Tong University; University of Otago; Beijing Children's Hospital; Illawarra Diabetes Services; Institute for Studies on Diabetes Foundation; Mater Medical Research Institute; Karolinska University Hospital; Fudan University; Christchurch Hospital New Zealand; Central Hospital of Yaounde FMBS; Steno Diabetes Center; Clinic University Hospital Valencia; Hospital Infantil Universitario Niño Jesús; University Children’s Hospital; Sechenov First Moscow State Medical University; Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universitat Frankfurt am Main; Universitat Ulm; University of Bristol; Malmo University Hospital; Hospital de Cruces; Salesi Hospital; Fakultni Nemocnice v Motole; University Campus Bio-Medico
    © The Author(s) 2010. Background and Purpose The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a) discover genes that modify type 1 diabetes risk; and (b) expand upon the existing genetic resources for type 1 diabetes research. The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide. Methods T1DGC was organized into four regional networks (Asia-Pacific, Europe, North America, and the United Kingdom) and a Coordinating Center. A Steering Committee, with representatives from each network, the Coordinating Center, and the funding organizations, was responsible for T1DGC operations. The Coordinating Center, with regional network representatives, developed study documents and data systems. Each network established laboratories for: DNA extraction and cell line production; human leukocyte antigen genotyping; and autoantibody measurement. Samples were tracked from the point of collection, processed at network laboratories and stored for deposit at National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repositories. Phenotypic data were collected and entered into the study database maintained by the Coordinating Center. Results T1DGC achieved its original ASP recruitment goal. In response to research design changes, the T1DGC infrastructure also recruited trios, cases, and controls. Results of genetic analyses have identified many novel regions that affect susceptibility to type 1 diabetes. T1DGC created a resource of data and samples that is accessible to the research community. Limitations Participation in T1DGC was declined by some countries due to study requirements for the processing of samples at network laboratories and/or final deposition of samples in NIDDK Central Repositories. Re-contact of participants was not included in informed consent templates, preventing collection of additional samples for functional studies. Conclusions T1DGC implemented a distributed, regional network structure to reach ASP recruitment targets. The infrastructure proved robust and flexible enough to accommodate additional recruitment. T1DGC has established significant resources that provide a basis for future discovery in the study of type 1 diabetes genetics.