Publication:
Designing and implementing sample and data collection for an international genetics study: The Type 1 Diabetes Genetics Consortium (T1DGC)

Issued Date

2010-08-01

Resource Type

Article

ISSN

17407753
17407745

DOI

10.1177/1740774510373497

Other identifier(s)

2-s2.0-79952279467

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Clinical Trials. Vol.7, No.1_suppl (2010), S5-S32

Suggested Citation

Joan E. Hilner, Letitia H. Perdue, Elizabeth G. Sides, June J. Pierce, Ana M. Wägner, Alan Aldrich, Amanda Loth, Lotte Albret, Lynne E. Wagenknecht, Concepcion Nierras, Beena Akolkar, Tracey Baskerville, Nines Bautista, Eesh Bhatia, Vijayalakshmi Bhatia, Kamaruzaman Bin Hasan, Francois Bonnici, Thomas Brodnicki, Brian Browning, Fergus Cameron, Katharee Chaichanwatanakul, Pik To Cheung, Peter Colman, Andrew Cotterill, Jenny Couper, Patricia Crock, Ric Cutfield, Tim Davis, Paul Dixon, Kim Donaghue, Katrina Dowling, Paul Drury, Sarah Dye, Shane Gellert, Rohana Abdul Ghani, Ristan Greer, Xueyao Han, Len Harrison, Nick Homatopoulos, Linong Ji, Tim Jones, Loke Kah Yin, Nor Azmi Kamaruddin, Uma Kanga, Alok Kanungo, Gurvinder Kaur, Betty Kek, Simon Knowles, Jeremy Krebs, Neeraj Kumar, Yann Jinn Lee, Xiaoying Li, Supawadee Liktimaskul, Margaret Lloyd, Amanda Loth, Anthony Louey, Narinder Mehra, Tony Merriman, Liu Min, Grant Morahan, Robert Moses, Grant Mraz, Rinki Murphy, Ian Nicholson, Araceli Panelo, Perlita Poh, Gareth Price, Nirubasini Ratnam, Carani Sanjeevi, Saikiran Sedimbi, Shuixian Shen, Goh Siok Ying, Brian Tait, Nikhil Tandon, Allison Thomas, Mike Varney, Praewvarin Weerakulwattana, Jinny Willis, Elvis Abang Akwo, Lotte Albret, Francisco Ampudia-Blasco, Jesus Argente, Magdalena Avbelj, Gulja Babadjanova, Klaus Badenhoop, Tadej Battelino, Georg Beilhack, Regine Bergholdt, Polly Bingley, Bernhard Boehm, Jo Bolidson, Kerstin Brismar, Caroline Brorsson, Joyce Carlson, Luis Castano, Kyla Chandler, Valentino Cherubini, Ondrej Cinek Designing and implementing sample and data collection for an international genetics study: The Type 1 Diabetes Genetics Consortium (T1DGC). Clinical Trials. Vol.7, No.1_suppl (2010), S5-S32. doi:10.1177/1740774510373497 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29920

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Title

Designing and implementing sample and data collection for an international genetics study: The Type 1 Diabetes Genetics Consortium (T1DGC)

Author(s)

Joan E. Hilner
 Letitia H. Perdue
 Elizabeth G. Sides
 June J. Pierce
 Ana M. Wägner
 Alan Aldrich
 Amanda Loth
 Lotte Albret
 Lynne E. Wagenknecht
 Concepcion Nierras
 Beena Akolkar
 Tracey Baskerville
 Nines Bautista
 Eesh Bhatia
 Vijayalakshmi Bhatia
 Kamaruzaman Bin Hasan
 Francois Bonnici
 Thomas Brodnicki
 Brian Browning
 Fergus Cameron
 Katharee Chaichanwatanakul
 Pik To Cheung
 Peter Colman
 Andrew Cotterill
 Jenny Couper
 Patricia Crock
 Ric Cutfield
 Tim Davis
 Paul Dixon
 Kim Donaghue
 Katrina Dowling
 Paul Drury
 Sarah Dye
 Shane Gellert
 Rohana Abdul Ghani
 Ristan Greer
 Xueyao Han
 Len Harrison
 Nick Homatopoulos
 Linong Ji
 Tim Jones
 Loke Kah Yin
 Nor Azmi Kamaruddin
 Uma Kanga
 Alok Kanungo
 Gurvinder Kaur
 Betty Kek
 Simon Knowles
 Jeremy Krebs
 Neeraj Kumar
 Yann Jinn Lee
 Xiaoying Li
 Supawadee Liktimaskul
 Margaret Lloyd
 Amanda Loth
 Anthony Louey
 Narinder Mehra
 Tony Merriman
 Liu Min
 Grant Morahan
 Robert Moses
 Grant Mraz
 Rinki Murphy
 Ian Nicholson
 Araceli Panelo
 Perlita Poh
 Gareth Price
 Nirubasini Ratnam
 Carani Sanjeevi
 Saikiran Sedimbi
 Shuixian Shen
 Goh Siok Ying
 Brian Tait
 Nikhil Tandon
 Allison Thomas
 Mike Varney
 Praewvarin Weerakulwattana
 Jinny Willis
 Elvis Abang Akwo
 Lotte Albret
 Francisco Ampudia-Blasco
 Jesus Argente
 Magdalena Avbelj
 Gulja Babadjanova
 Klaus Badenhoop
 Tadej Battelino
 Georg Beilhack
 Regine Bergholdt
 Polly Bingley
 Bernhard Boehm
 Jo Bolidson
 Kerstin Brismar
 Caroline Brorsson
 Joyce Carlson
 Luis Castano
 Kyla Chandler
 Valentino Cherubini
 Ondrej Cinek

Other Contributor(s)

University of Alabama at Birmingham
 Wake Forest University Health Sciences
 Hagedorn Research Institute
 Hospital Insular, Las Palmas
 Universidad de Las Palmas de Gran Canaria
 University of Alaska Anchorage
 Walter and Eliza Hall Institute of Medical Research
 Juvenile Diabetes Research Foundation International
 National Institute of Diabetes and Digestive and Kidney Diseases
 Mater Hospital
 Institute for Study on Diabetes Foundation
 Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow
 National University of Malaysia Hospital
 University of Cape Town
 University of Auckland
 Royal Children's Hospital, Melbourne
 Mahidol University
 Queen Mary Hospital Hong Kong
 Women’s and Children’s Hospital
 John Hunter Children’s Hospital
 North Shore Hospital
 Fremantle Hospital and Health Service
 Diabetes Lifestyle Centre
 Children's Hospital At Westmead
 Australian Red Cross Blood Service
 Auckland Diabetes Centre
 Western Australia Institute for Medical Research
 Royal Melbourne Hospital
 University of Queensland
 Peking University
 Princess Margaret Hospital for Children
 Children's Medical Institute
 All India Institute of Medical Sciences, New Delhi
 Cuttack Diabetes Research Foundation
 Diabetes Centre
 Mackay Memorial Hospital Taiwan
 Shanghai Jiao Tong University
 University of Otago
 Beijing Children's Hospital
 Illawarra Diabetes Services
 Institute for Studies on Diabetes Foundation
 Mater Medical Research Institute
 Karolinska University Hospital
 Fudan University
 Christchurch Hospital New Zealand
 Central Hospital of Yaounde FMBS
 Steno Diabetes Center
 Clinic University Hospital Valencia
 Hospital Infantil Universitario Niño Jesús
 University Children’s Hospital
 Sechenov First Moscow State Medical University
 Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universitat Frankfurt am Main
 Universitat Ulm
 University of Bristol
 Malmo University Hospital
 Hospital de Cruces
 Salesi Hospital
 Fakultni Nemocnice v Motole
 University Campus Bio-Medico

Abstract

© The Author(s) 2010. Background and Purpose The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a) discover genes that modify type 1 diabetes risk; and (b) expand upon the existing genetic resources for type 1 diabetes research. The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide. Methods T1DGC was organized into four regional networks (Asia-Pacific, Europe, North America, and the United Kingdom) and a Coordinating Center. A Steering Committee, with representatives from each network, the Coordinating Center, and the funding organizations, was responsible for T1DGC operations. The Coordinating Center, with regional network representatives, developed study documents and data systems. Each network established laboratories for: DNA extraction and cell line production; human leukocyte antigen genotyping; and autoantibody measurement. Samples were tracked from the point of collection, processed at network laboratories and stored for deposit at National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repositories. Phenotypic data were collected and entered into the study database maintained by the Coordinating Center. Results T1DGC achieved its original ASP recruitment goal. In response to research design changes, the T1DGC infrastructure also recruited trios, cases, and controls. Results of genetic analyses have identified many novel regions that affect susceptibility to type 1 diabetes. T1DGC created a resource of data and samples that is accessible to the research community. Limitations Participation in T1DGC was declined by some countries due to study requirements for the processing of samples at network laboratories and/or final deposition of samples in NIDDK Central Repositories. Re-contact of participants was not included in informed consent templates, preventing collection of additional samples for functional studies. Conclusions T1DGC implemented a distributed, regional network structure to reach ASP recruitment targets. The infrastructure proved robust and flexible enough to accommodate additional recruitment. T1DGC has established significant resources that provide a basis for future discovery in the study of type 1 diabetes genetics.

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/29920

Collections

Scopus 2006-2010