Browsing by Author "University of Illinois at Chicago"

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    2-Substituted furans from Polyalthia suberosa
    (2001-09-11) P. Tuchinda; M. Pohmakotr; V. Reutrakul; W. Thanyachareon; S. Sophasan; C. Yoosook; T. Santisuk; J. M. Pezzuto; Mahidol University; Thailand Royal Forest Department; University of Illinois at Chicago
    Two new 2-substituted furans, 1-(2-furyl)pentacosa-16,18-diyne and 23-(2-furyl)tricosa-5,7-diynoic acid, have been isolated from stems of Polyalthia suberosa. The structures were assigned by spectroscopic methods. The two compounds together with the previously reported kalasinamide, N-trans-feruloyltyramine and N-trans-coumaroyltyramine showed anti-HIV activities.
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    The Asia Cornea Society Infectious Keratitis Study: A Prospective Multicenter Study of Infectious Keratitis in Asia
    (2018-11-01) Wei Boon Khor; Venkatesh N. Prajna; Prashant Garg; Jodhbir S. Mehta; Lixin Xie; Zuguo Liu; Ma Dominga B. Padilla; Choun Ki Joo; Yoshitsugu Inoue; Panida Goseyarakwong; Fung Rong Hu; Kohji Nishida; Shigeru Kinoshita; Vilavun Puangsricharern; Ai Ling Tan; Roger Beuerman; Alvin Young; Namrata Sharma; Benjamin Haaland; Francis S. Mah; Elmer Y. Tu; Fiona J. Stapleton; Richard L. Abbott; Donald Tiang Hwee Tan; Duke-NUS Medical School Singapore; Dr. Rajendra Prasad Centre for Ophthalmic Sciences; National Taiwan University Hospital; University of the Philippines Manila; St. Luke's Medical Center Quezon City; Aravind Eye Care System; Kyoto Prefectural University of Medicine; University of New South Wales (UNSW) Australia; Chulalongkorn University; University of Illinois at Chicago; Yong Loo Lin School of Medicine; Prince of Wales Hospital Hong Kong; Singapore Eye Research Institute; University of California, San Francisco; L.V. Prasad Eye Institute India; Singapore General Hospital; Osaka University Faculty of Medicine; Faculty of Medicine, Siriraj Hospital, Mahidol University; Tottori University; Singapore National Eye Centre; Scripps Clinic; The Catholic University of Korea; Xiemen Eye Center; SHANDONG EYE INSTITUTE
    © 2018 Elsevier Inc. Purpose: To survey the demographics, risk factors, microbiology, and outcomes for infectious keratitis in Asia. Design: Prospective, nonrandomized clinical study. Methods: Thirteen study centers and 30 sub-centers recruited consecutive subjects over 12-18 months, and performed standardized data collection. A microbiological protocol standardized the processing and reporting of all isolates. Treatment of the infectious keratitis was decided by the managing ophthalmologist. Subjects were observed for up to 6 months. Main outcome measures were final visual acuity and the need for surgery during infection. Results: A total of 6626 eyes of 6563 subjects were studied. The majority of subjects were male (n = 3992). Trauma (n = 2279, 34.7%) and contact lens wear (n = 704, 10.7%) were the commonest risk factors. Overall, bacterial keratitis was diagnosed in 2521 eyes (38.0%) and fungal keratitis in 2166 eyes (32.7%). Of the 2831 microorganisms isolated, the most common were Fusarium species (n = 518, 18.3%), Pseudomonas aeruginosa (n = 302, 10.7%), and Aspergillus flavus (n = 236, 8.3%). Cornea transplantation was performed in 628 eyes to manage ongoing infection, but 289 grafts (46%) had failed by the end of the study. Moderate visual impairment (Snellen vision less than 20/60) was documented in 3478 eyes (53.6%). Conclusion: Demographic and risk factors for infection vary by country, but infections occur predominantly in male subjects and are frequently related to trauma. Overall, a similar percentage of bacterial and fungal infections were diagnosed in this study. Visual recovery after infectious keratitis is guarded, and corneal transplantation for active infection is associated with a high failure rate.
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    The Association between Daytime Napping Characteristics and Bone Mineral Density in Elderly Thai Women without Osteoporosis
    (2018-12-01) Sunee Saetung; Sirimon Reutrakul; La Or Chailurkit; Rajata Rajatanavin; Boonsong Ongphiphadhanakul; Hataikarn Nimitphong; University of Illinois at Chicago; Faculty of Medicine, Ramathibodi Hospital, Mahidol University
    © 2018 The Author(s). Low bone mass is more prevalent with increasing age. Studies have found associations between sleep duration, sleep quality and obstructive sleep apnea and bone mineral density (BMD). However, less is known about the relationship between daytime napping and BMD. We aimed to investigate the association between daytime napping and BMD in elderly Thai women. Demographic data, lifestyle information and sleep characteristics were obtained by interviewing 387 elderly women. Weight and height were measured. Serum 25-hydroxyvitamin D [25(OH)D] was measured by radioimmunoassay. BMD was measured by dual-energy X-ray absorptiometry (DXA). Higher BMI and having type 2 diabetes (T2DM) were correlated with higher lumbar spine 2-4 (L2-4) BMD, while younger age, higher BMI and higher serum 25(OH)D level were correlated with higher femoral neck (FN) and total hip (TH) BMD. After adjusting for age, age at menopause, BMI, 25(OH)D level and T2DM, a higher frequency of weekly daytime napping was associated with lower FN and TH BMD but not at L2-4 BMD. Additionally, longer daytime napping duration was negatively associated with BMD at TH. In summary higher frequency and longer duration of daytime napping are associated with lower femoral BMD in elderly women. Mechanisms underlying these associations should be further explored.
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    Association between nocturnal hypoxemic burden and glucose metabolism
    (2021-01-01) Sikawat Thanaviratananich; Hao Cheng; Naricha Chirakalwasan; Sirimon Reutrakul; University of Illinois at Chicago; King Chulalongkorn Memorial Hospital; Faculty of Medicine Ramathibodi Hospital, Mahidol University; Miami VA Healthcare System; University of Iowa Carver College of Medicine; Faculty of Medicine, Chulalongkorn University
    Purpose: To evaluate the association between a novel integrated event-based and hypoxemia-based parameter of polysomnography (PSG), hypoxemic load or HL100, and fasting blood glucose (FBG) and hemoglobin A1c (HbA1c) levels. Methods: Adult patients, who underwent an in-lab PSG at the University of Iowa Hospitals and Clinics with FBG or HbA1c levels, were included. Event-based parameter and hypoxemia-based parameter data were derived. HL100, defined as the integrated area of desaturation between the 100% oxygen saturation and the measured saturation levels during sleep divided by the total sleep time, was calculated by Python software. Demographic data and glycemic parameters within 1 year prior to PSG (FBG and HbA1c) were retrieved from chart review. Spearman correlation analysis and stepwise backward regression analysis were performed to determine independent predictors of FBG and HbA1c levels. Results: Of the 467 patients who underwent an in-lab PSG, 218 had FBG levels, 84 had HbA1c levels, and 118 had both values. All event-based and hypoxemia-based parameters, including HL100, were significantly correlated to FBG and HbA1c levels. Stepwise backward regression analyses, adjusted for age, sex, body mass index, and diabetes status, revealed that log HL100 was significantly related to FBG (B = 23.9, p = 0.010), but none of log event-based or hypoxemia-based parameters were found to be significantly related HbA1c levels. Conclusions: HL100 was shown to be an independent predictor of FBG in this cohort, implying that any degree of desaturation below 100% could adversely affect glucose metabolism. HL100 may be useful for interpretation of sleep studies, risk stratification, and patient management purposes in the future.
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    Bioactive butenolides from Melodorum fruticosum
    (1991-01-01) Patoomratana Tuchinda; Jinda Udchachon; Vichai Reutrakul; Thawatchai Santisuk; Walter C. Taylor; Norman R. Farnsworth; John M. Pezzuto; A. Douglas Kinghorn; Mahidol University; Thailand Royal Forest Department; The University of Sydney; University of Illinois at Chicago
    From leaves and branches of Melodorum fruticosum, five butenolides have been isolated: (4Z)-6-acetoxy-7-benzoyloxy-2,4-heptadien-4-olide, (4E)-6-acetoxy-7-benzoyloxy-2,4-heptadien-4-olide, (4Z)-7-benzoyloxy-6-hydroxy-2,4-heptadien-4-olide, (4E)-7-benzoyloxy-6-hydroxy-2,4-heptadien-4-olide and (4Z)-6-benzoyloxy-7-hydroxy-2,4-heptadien-4-olide. In addition, two known flavonoids (chrysin, pinocembrin) and benzoic acid were isolated. All butenolides showed cytotoxic activities in several tumour cell lines. The structures of the isolated compounds were elucidated by spectroscopic methods. © 1991.
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    Bioactive constituents from roots of Bursera tonkinensis
    (2005-12-01) Aranya Jutiviboonsuk; Hongjie Zhang; Ghee Teng Tan; Cuiying Ma; Nguyen Van Hung; Nguyen Manh Cuong; Nuntavan Bunyapraphatsara; D. Doel Soejarto; Harry H.S. Fong; Mahidol University; University of Illinois at Chicago; Vietnamese Academy of Science and Technology Institute of Chemistry; Cuc Phuong National Park
    Bioassay directed-fractionation led to isolation of 12 compounds from the roots of Bursera tonkinensis Guillaum (Burseraceae), including burselignan, bursephenylpropane, and burseneolignan. Of the 12 compounds, only 4′-demethyldesoxypodophyllotoxin exhibited significant cytotoxic activities against KB, Col2 and LNCaP cell lines. © 2005 Elsevier Ltd. All rights reserved.
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    Bioactive dammarane triterpenes from the mangrove Plant Bruguiera gymnorrhiza
    (2006-03-01) Sudarat Homhual; Nuntavan Bunyapraphatsara; Tamara Kondratyuk; Angkana Herunsalee; Wongsatit Chaukul; John M. Pezzuto; Harry H S Fong; Hong Jie Zhang; Mahidol University; Purdue University; Thailand Ministry of Public Health; University of Illinois at Chicago
    Three new dammarane triterpenes, bruguierins A-C (1-3), were isolated from a petroleum ether extract of the flowers of Bruguiera gymnorrhiza. Their structures were determined on the basis of physical and spectroscopic data interpretation. With stably transfected HepG2 cells, the three isolates activated antioxidant response element (ARE luciferase activation) with EC50 values of 7.8, 9.4, and 15.7 μM, respectively. Bruguierin A (1) also inhibited phorbol ester-induced NFκB (nuclear factor-κB) luciferase activation with an IC50 value of 1.4 μM and selectively inhibited cyclooxygenase-2 (COX-2) activity with an IC50 value of 0.37 μM. Compounds 2 and 3 were not active in these bioassays. © 2006 American Chemical Society and American Society of Pharmacognosy.
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    Boston type 1 keratoprosthesis: Updated perspectives
    (2020-01-01) Manachai Nonpassopon; Muanploy Niparugs; Maria Soledad Cortina; University of Illinois at Chicago; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Chiang Mai University
    © 2020 Nonpassopon et al. The use of Boston type 1 keratoprosthesis (BKPro) has significantly increased worldwide. It is no longer considered a procedure of last resort but a reasonable option for patients with otherwise poor prognosis for a traditional penetrating keratoplasty. BKPro was approved by the Food and Drug Administration in 1992 for bilateral severe corneal blindness due to multiple corneal transplant failure. Over the years, indications have extended beyond recurrent immunologic rejection to include other conditions such as chemical injury and other causes of bilateral limbal stem cell deficiency, extensive corneal neovascularization, neurotrophic corneas and hypotony, among others. Numerous advances in the design of the BKPro, improvement of preoperative, intraoperative and postoperative management have resulted in favorable outcomes and a reduction in postoperative complications. Accordingly, many studies have shown that implantation of this device is highly effective in restoring vision with very good short-term outcomes. However, due to the lifetime risk of sight-threatening complications after BKPro implan-tation, a longer follow-up period should provide outcomes that are more realistic. In this review, the authors examined only the results of publications with an average of at least 2 years of follow-up. The overall intermediate to long-term visual outcomes and retention rate in BKPro seem to be favorable. However, autoimmune diseases and cicatrizing conditions continue to show a higher incidence of postoperative complications that require further management.
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    Botanicals in dietary supplements
    (2013-11-18) Weena Jiratchariyakul; Ludger Beerhues; Gail B. Mahady; Tanawan Kummalue; Molvibha Vongsakul; Mahidol University; Technische Universitat Braunschweig; University of Illinois at Chicago
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    Breastfeeding experiences among Thai adolescent mothers: A descriptive qualitative study
    (2018-10-01) Sasitara Nuampa; Fongcum Tilokskulchai; Nittaya Sinsuksai; Crystal L. Patil; Wanna Phahuwatanakorn; University of Illinois at Chicago; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol University
    The benefits of breastfeeding for the health of mothers and their infants are well-recognized. In comparison to other age groups of mothers, however, adolescent mothers have lower rates of breastfeeding duration and exclusivity. To develop unique breastfeeding intervention, it is crucial to understand what adolescent mothers perceive about breastfeeding. This study explored Thai adolescent mothers' experiences related to breastfeeding for the first six months. A descriptive qualitative design was conducted using semi-structured, in-depth interviews. Twenty adolescent mothers were purposively recruited. Descriptive statistics and content analysis were used for data analysis. The findings revealed that adolescent mothers explained their breastfeeding experiences through the following five themes: identifying positive aspects of breastfeeding; breastfeeding challenges; social support; returning to work/studies, and breastfeeding in public. These themes were found to be related to breastfeeding decisions, duration, and exclusivity. Breastfeeding experiences among Thai adolescent mothers showed complex factors involving multilevel influences of social systems. Therefore, promotion and support of successful breastfeeding should recognize the influences of personal factors of adolescent mothers and their environments simultaneously, particularly complexity of family problems. Nurse professionals should provide breastfeeding knowledge and skills during the antenatal period adding family involvement, especially infants' grandmothers. Moreover, understanding unique adolescents and their needs should be emphasized in breastfeeding promotion programs in order to reduce breastfeeding difficulties and increase breastfeeding sustainability. Planning to overcome breastfeeding barriers within schools, workplaces and the public should be supported and encouraged among adolescent mothers and their families.
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    Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza
    (2006-02-01) Sudarat Homhual; Hong Jie Zhang; Nuntavan Bunyapraphatsara; Tamara P. Kondratyuk; Bernard D. Santarsiero; Andrew D. Mesecar; Angkana Herunsalee; Wongsatit Chaukul; John M. Pezzuto; Harry H.S. Fong; Mahidol University; University of Illinois at Chicago; Purdue University; Thailand Ministry of Public Health
    A new cyclic 4-hydroxy-dithiosulfonato, bruguiesulfurol (1), as well as two known 4-hydroxydithiolane 1-oxides, brugierol (2) and isobrugierol (3) were isolated from the flowers of Bruguiera gymnorrhiza. With stably-transfected HepG2 cells, the three isolates activated antioxidant response element (ARE) luciferase activation with (EC50) values of 56.7, 3.7 and 1.8 μM, respectively. Compounds 2 and 3 also inhibited phorbol ester-induced NF-κB (nuclear factor-κB) luciferase activity with IC50 values of 85.0 and 14.5 μM, respectively. In addition, compound 2 inhibited enzyme cyclooxygenase-2 (COX-2) activity with an IC50 value of 6.1 μM. The structures of these isolates were determined by spectral data, and that of compound 1 was confirmed by X-ray crystallographic analysis. © Georg Thieme Verlag KG Stuttgart.
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    Chronic high-dose testosterone treatment: impact on rat cardiac contractile biology
    (2019-07-01) Munthana Wadthaisong; Namthip Witayavanitkul; Tepmanas Bupha-Intr; Jonggonnee Wattanapermpool; Pieter P. de Tombe; University of Illinois at Chicago; Mahidol University; Loyola University of Chicago
    © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. Androgen therapy provides cardiovascular benefits for hypogonadism. However, myocardial hypertrophy, fibrosis, and infarction have been reported in testosterone or androgenic anabolic steroid abuse. Therefore, better understanding of the factors leading to adverse results of androgen abuse is needed. The aim of the present study was to examine the impact of high dose of androgen treatment on cardiac biology, and whether exposure duration modulates this response. Male rats were treated with 10 mg/kg testosterone, three times a week, for either 4 or 12 weeks; vehicle injections served as controls. Four weeks of testosterone treatment induced an increase in ventricular wall thickness, indicative of concentric hypertrophy, as well as increased ejection fraction; in contrast, both parameters were blunted following 12 weeks of high-dose testosterone treatment. Cardiac myocyte contractile parameters were assessed in isolated electrically stimulated myocytes (sarcomere and intracellular calcium dynamics), and in chemically permeabilized isolated myocardium (myofilament force development and tension-cost). High-dose testosterone treatment for 4 weeks was associated with increased myocyte contractile parameters, while 12 weeks treatment induced significant depression of these parameters, mirroring the cardiac pump function results. In conclusion, chronic administration of high-dose testosterone initially induces increased cardiac function. However, this initial beneficial impact is followed by significant depression of cardiac pump function, myocyte contractility, and cardiac myofilament function. Our results indicate that chronic high-testosterone usage is of limited use and may, instead, induce significant cardiac dysfunction.
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    Consistent condom use among Thai heterosexual adult males in Bangkok, Thailand
    (2011-04-01) Poolsuk Janepanish; Barbara L. Dancy; Chang Park; Mahidol University; University of Illinois at Chicago
    Thai heterosexual males between 20 and 39 years old are at increased risk for HIV infection. Consistent condom use is effective against HIV transmission, but little is known about determinants of consistent condom use for these males. The purpose of this study is to explore determinants of consistent condom use for this population. The determinants of interest are age, educational level, marital status, income, and concepts from the theory of planned behavior: attitude toward condom use, subjective norm about consistent condom use, perceived behavioral control (PBC) of consistent condom use, and intention to use condoms consistently. We used a cross-sectional descriptive research design with a convenience sample of 400 heterosexual Thai males between 20 and 39 years. Our sample had a mean age of 28.71 years (SD = 6.33). During the last three months, 39.5% reported using condoms consistently, 23% reported using condoms inconsistently, and 37.5% reported never using condoms. The results from the regression analyses revealed that marital status, income, subjective norm about consistent condom use, PBC of consistent condom use, and intention to use condoms consistently were determinants of consistent condom use. Also the effect of subjective norm about consistent condom use and PBC of consistent condom use on consistent condom use was mediated by intention to use condoms consistently. These results suggest that interventions to increase consistent condom use should focus on enhancing intention to use condoms consistently by promoting subjective norm about consistent condom use and PBC of consistent condom use. © 2011 Taylor & Francis.
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    Constituents of the leaves and twigs of Ficus hispida
    (2002-03-05) Sergio R. Peraza-Sánchez; Hee Byung Chai; Geun Shin Young; Thawatchai Santisuk; Vichai Reutrakul; Norman R. Farnsworth; Geoffrey A. Cordell; John M. Pezzuto; A. Douglas Kinghorn; University of Illinois at Chicago; The Forest Herbarium, Thailand Ministry of Natural Resources and Environment; Mahidol University
    A new norisoprenoid, ficustriol (1), and the known phenanthroindolizidine alkaloid O-methyltylophorinidine (2), were isolated from a CHCI3 extract of the leaves and twigs of Ficus hispida. O-Methyltylophorinidine showed potent cytotoxic activity when tested against a small panel of human cancer cells, while ficustriol was inactive. The structure and stereochemistry of 1 were determined using chemical and spectral methods.
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    The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
    (2019-06-01) Hataikarn Nimitphong; Nantaporn Siwasaranond; Chanika Sritara; Sunee Saetung; La or Chailurkit; Naricha Chirakalwasan; Boonsong Ongphiphadhanakul; Sirimon Reutrakul; Chulalongkorn University; University of Illinois at Chicago; King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University; Faculty of Medicine, Ramathibodi Hospital, Mahidol University
    © 2019 The Authors Aims: Type 2 diabetes mellitus (T2DM)and obstructive sleep apnea (OSA)may adversely affect bone. Gender is a well-established factor influencing bone health. We investigated the impact of OSA on bone mineral density (BMD)and trabecular bone score (TBS)in T2DM. Methods: Eighty-one T2DM patients [33 men and 48 women]participated. OSA was diagnosed using an overnight monitor, with its severity assessed by an apnea hypopnia index (pAHI). The measurements of hypoxia, including the percentage of total sleep time in which oxygen saturation remains below 90% (pT90), the oxygen desaturation index (pODI)and minimum O2 (min O2), were reported. Lumbar spine (L1-4)and femoral neck (FN)BMD were measured using dual-energy X-ray absorptiometry (DXA). TBS was computed from DXA images. Results: Sixty-five patients (80.2%)had OSA. pAHI, pT90, pODI and min O2 were not correlated to L1-4 BMD, FN BMD or TBS in all participants by multiple regression analyses adjusting for age, gender and BMI. However, an interaction between gender and pAHI, and gender and pODI were significantly associated with TBS (b = 0.003, p = 0.034 and b = 0.004, p = 0.046, respectively). We therefore reassessed an association between pAHI or pODI and TBS separately between men and women. After adjusting for age and BMI, more severe OSA (higher pAHI)and higher pODI significantly associated with lower TBS (b = −0.002, p = 0.034 and b = −0.003, p = 0.021, respectively)in men. On the other hand, higher pAHI non-significantly associated with better trabecular microarchitecture as indicated by higher TBS (b = 0.002, p = 0.059)in women. When considered only postmenopausal (n = 33), higher pAHI and higher pODI were significantly associated with higher TBS (b = 0.004, p = 0.003 and b = 0.004, p = 0.008, respectively). Conclusions: In T2DM patients, there is a complex interrelationship among OSA severity, gender and TBS. More severe OSA predicted lower TBS in men, but predicted higher TBS in postmenopausal women.
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    Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis
    (2017-01-01) Thunyarat Anothaisintawee; Dumrongrat Lertrattananon; Sangsulee Thamakaison; Sirimon Reutrakul; Boonsong Ongphiphadhanakul; Ammarin Thakkinstian; Mahidol University; University of Illinois at Chicago
    © 2017 Thunyarat Anothaisintawee et al. Purpose. To estimate both direct and indirect effects (through obesity) of serum uric acid (SUA) on blood sugar in prediabetes patients. Methods. Prediabetes patients who came to the outpatient clinic of the Department of Family Medicine, Ramathibodi Hospital, were included in this cross-sectional study. Mediation analysis was applied to determine direct and indirect effects of SUA on glycemic parameters (fasting plasma glucose (FPG) and HbA1c) through waist circumference (WC). A mediation effect was estimated using the product-of-coefficient method with a bootstrap analysis of 1000 replications. Results. 1043 patients were eligible for this study. Every 1 mg/dl increase in SUA was associated with an increase in WC and then was significantly associated with an increase in FPG by 0.082 mg/dl (95% CI: 0.010, 0.154). SUA was directly associated with FPG with a coefficient of 0.413 (95% CI: 0.049, 0.776). For HbA1c, every one mg/dl increase in SUA was associated with an increase in HbA1c level through WC by 0.006 (95% CI: 0.003, 0.010). However, SUA was not directly associated with HbA1c. Conclusions. We found that an increase in SUA was directly and indirectly associated with increased FPG but the effect of SUA on HbA1c was shown when it was mediated through WC.
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    Effect of bioelectrical impedance analysis-guided dry weight adjustment, in comparison to standard clinical-guided, on the sleep quality of chronic haemodialysis patients (BEDTIME study): A randomised controlled trial
    (2019-09-02) Sethanant Sethakarun; Sutachard Bijaphala; Chagriya Kitiyakara; Sarinya Boongird; Pariya Phanachet; Sirimon Reutrakul; Kwanchai Pirojsakul; Arkom Nongnuch; University of Illinois at Chicago; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Vichaiyut Hospital
    © 2019 The Author(s). Background: Sleep disturbance is common among chronic haemodialysis patients, which leads to poor quality of life, in addition to increased instances of morbidity and mortality. Hypervolemia has been linked to sleep problems observed in chronic haemodialysis patients, which suggests that optimising one's fluid status could improve the sleep quality of this patient group. In our study, we subjectively examined and objectively measured sleep parameters, using actigraphy recordings, the Pittsburgh Sleep Quality Index (PSQI) questionnaire, and Epworth Sleepiness Scale (ESS), in order to compare bioelectrical impedance analysis (BIA)-guided and standard clinical-guided dry weight adjustment. Methods: We randomly selected 19 chronic haemodialysis patients with subclinical hypervolemia, defined as a clinically euvolemic status, despite the ratio of extracellular water to total body water being more than 0.4 in BIA. Furthermore, these patients, who were poor sleepers (PSQI > 5), were assigned to either a BIA-guided dry weight group (BIA group) or a standard clinical-guided one (clinical group). The primary outcome was changes in sleep actigraphy parameters between the groups at 1, 3, and 6 months. Changes observed in the PSQI and ESS score between the two groups over the same period of time were the secondary endpoints. Results: The mean age of the participants was 63.53 ± 11.12 years, and 42% of them were male. All sleep parameters measured by means of actigraphy were not significantly different between the two groups. Interestingly, at 3 and 6 months, the subjective sleep quality significantly improved in the BIA group, as reflected by a greater decline in the PSQI score, in comparison with the clinical group (3 months: mean difference - 1.82 [- 3.13 to - 0.51], P = 0.006; 6 months: mean difference - 3.16 [- 4.49 to - 1.83], P < 0.001). However, sleepiness assessed by the ESS was not significantly different between the groups throughout the study. Conclusions: Optimisation of the fluid status by employing BIA did not improves sleep actigraphy parameter, however, it significantly ameliorates the subjective sleep quality of chronic haemodialysis patients. This observation should be further explored in larger samples and longer clinical trials. Trial registration: This trial was registered at ClinicalTrials.gov (NCT02825589) on July 7, 2016.
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    The effect of probiotic yogurt on glycemic control in type 2 diabetes or obesity: A meta-analysis of nine randomized controlled trials
    (2019-03-01) Elena Barengolts; Emily Daviau Smith; Sirimon Reutrakul; Livia Tonucci; Thunyarat Anothaisintawee; Jesse Brown VA Medical Center; University of Illinois at Chicago; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; University Center INTA-UNINTA
    © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Probiotic yogurt is suggested as a nutritional approach in type 2 diabetes (T2D) and obesity. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating the effects of probiotic yogurt on glycemic outcomes in T2D or obesity. The databases used to search for RCTs included Medline and Scopus. The RCTs were eligible if outcomes included selected glycemic markers. In nine eligible trials, 237 and 235 subjects were in treatment (probiotic yogurt) and control (mostly conventional yogurt) groups, respectively. There was no significant difference for pooled unstandardized mean difference (USMD) hemoglobin A1c (HbA1c) by probiotic yogurt compared with the control in T2D (USMD: -0.366; 95% CI: -0.755, 0.024, p = 0.066) and obesity (USMD: 0.116, 95% CI: -0.007, 0.238, p = 0.065). Similarly, there were no effects of probiotic yogurt on fasting blood glucose, fasting insulin, or insulin resistance (estimated by homeostatic model assessment of insulin resistance (HOMA-IR)) in either T2D or obesity. In conclusion, the present meta-analysis has not demonstrated the benefits of consuming probiotic compared with conventional yogurt for improving glucose control in patients with diabetes or obesity. Larger trials are needed to verify the benefits of probiotic and/or conventional yogurt or other probiotic fermented milk (e.g., kefir) on glycemic markers in patients with diabetes and obesity.
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    Effects of an intensive lifestyle intervention and the role of sleep in people living with HIV and prediabetes: a pilot and feasibility study
    (2021-12-01) Hataikarn Nimitphong; Somnuek Sungkanuparph; Chatvara Areevut; Sunee Saetung; Ratanaporn Jerawatana; Amornrat Hathaidechadusadee; Supaporn Somwang; Wanabhorn Tongchom; Nampeth Saibuathong; Jandanee Sakmanarit; Orawan Pichitchaipitak; Angsana Phuphuakrat; Sirimon Reutrakul; University of Illinois at Chicago; Faculty of Medicine Ramathibodi Hospital, Mahidol University
    Objectives: Prediabetes is prevalent in people living with HIV (PLWH). Insufficient and irregular sleep are linked to abnormal glucose metabolism. This study aimed to investigate the differences in sleep characteristics between PLWH with and without prediabetes, determine the acceptability/feasibility and effects of a pilot six-month intensive lifestyle intervention (ILI) program on glucose metabolism in those with prediabetes, and determine how sleep modulates these effects. Results: Thirty-nine PLWH (20 normoglycemia and 19 prediabetes) participated. There were no differences in sleep characteristics between individuals with normoglycemia and prediabetes. Next, thirteen individuals with prediabetes completed a six-month ILI program. The ILI program resulted in significant body weight reduction at 6 months (63.5 ± 13.9 to 61.9 ± 14.0 kg, p = 0.012), which was maintained at 12 months (p < 0.001). Waist circumferences were significantly decreased at 12 months (85.4 ± 11.7 to 82.9 ± 12.7 cm, p = 0.014). An increase in sleep variability was significantly associated with an increase in 2-h plasma glucose, independent of changes in BMI (b = 0.603), and physical activity (b = 0.774). This pilot study suggested that ILI in PLWH with prediabetes is feasible and effective in improving metabolic control, with its effects possibly modulated by sleep variability. These findings should be confirmed in a larger study to reduce diabetes risk in this population. Trail registration: ClinicalTrial.gov, NCT03545217 (date of registration: May 22, 2018)
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    Effects of bedroom environmental conditions on the severity of obstructive sleep apnea
    (2018-04-15) Sattamat Lappharat; Nutta Taneepanichskul; Sirimon Reutrakul; Naricha Chirakalwasan; Chulalongkorn University; University of Illinois at Chicago; King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University; Faculty of Medicine, Ramathibodi Hospital, Mahidol University
    © 2018 American Academy of Sleep Medicine. All rights reserved. Study Objectives: Epidemiological associations have demonstrated the effects of long-term air pollution to obstructive sleep apnea (OSA) through a physiological mechanism linking particulate matter exposure to OSA. This study aimed to determine the relationship between bedroom environmental conditions, OSA severity, and sleep quality. Methods: Sixty-three participants were enrolled for an overnight polysomnography; OSA was diagnosed between May to August 2016. Personal characteristics and sleep quality were obtained by a face-to-face interview. Bedroom environments, including data on particulate matter with an aerodynamic diameter less than 10 μm (PM10), temperature, and relative humidity, were collected by personal air sampling and a HOBO tempt/RH data logger. Results: Sixty-eight percent of the participants experienced poor sleep. An elevation in 1-year mean PM10 concentration was significantly associated with an increase in apnea-hypopnea index (beta = 1.04, P =.021) and respiratory disturbance index (beta = 1.07, P =.013). An increase of bedroom temperature during sleep was significantly associated with poorer sleep quality (adjusted odds ratio 1.46, 95% confidence interval 1.01-2.10, P =.044). Associations between PM10 concentration and respiratory disturbance index were observed in the dry season (beta = 0.59, P =.040) but not in the wet season (beta = 0.39, P =.215). PM10 was not associated with subjective sleep quality. Conclusions: Elevation of PM10 concentration is significantly associated with increased OSA severity. Our findings suggest that reduction in exposure to particulate matter and suitable bedroom environments may lessen the severity of OSA and promote good sleep.